L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- | 76970-94-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
• 英文别名: (2S)-2-[(2-bromoacetyl)amino]-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
• CAS: 76970-94-0
• 化学式: C₁₇H₁₃BrI₃NO₅
• 分子量: 771.9
• InChiKey: AGUVIBCJWRFUTQ-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三碘甲状腺原氨酸 、 溴乙酰溴 以 乙酸乙酯 为溶剂， 以to yield highly pure N-bromoacetyl-3,3',5-triiodo-L-thyronine的产率得到L-Tyrosine, N-(bromoacetyl)-O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
  参考文献：
  名称：

  Synthesis and characterization of

  摘要：

  一种合成N-溴乙酰基-3,3',5-三碘-L-甲状腺素的方法，涉及将3,3'，5-三碘-L-甲状腺素置于乙酸乙酯溶液中，与溴乙酰溴反应进行一步溴乙酰化反应。形成N-溴乙酰基-3,3'-三碘-L-甲状腺素后，通过高速逆流色谱分离纯化。可以通过将[.sup.125 I]T.sub.3或[.sup.14 C]T.sub.3与溴乙酰溴还原反应进行一步溴乙酰化反应来制备标记的N-溴乙酰基-3,3',5-三碘-L-甲状腺素。

  公开号：

  US05169984A1

文献信息

• Use of monocarboxylate transporter protein for thyroid hormone transport
  申请人：Friesema C. H. Edith

  公开号：US20050159352A1

  公开（公告）日：2005-07-21

  The use of a monocarboxylate transporter protein or a functional part, derivative and/or analogue thereof for altering transport of a thyroid hormone or a functional part, derivative and/or analogue thereof across a membrane. The monocarboxylate transporter protein preferably comprises MCT-8. An isolated molecule capable of specifically binding at least part of an MCT protein, at least part of a ligand of an MCT protein, or a nucleic acid encoding the MCT and/or ligand, is also herewith provided. Regulation of the bioavailability of thyroid hormone in a tissue enables interfering with diseases. The invention also provides pharmaceutical compositions comprising a compound capable of binding the MCT protein or capable of influencing the binding or transporting of a ligand of the MCT protein. Methods for diagnosis and/or treatment of a disease, such as a disorder of thyroid metabolism, non-thyroidal illness, obesity or cardiovascular illness, are also provided, as well as bioassays for identifying or detecting a candidate drug capable of binding to, or influencing at least part of, the MCT protein.
• US5169984A
  申请人：——

  公开号：US5169984A

  公开（公告）日：1992-12-08
• US5354473A
  申请人：——

  公开号：US5354473A

  公开（公告）日：1994-10-11
• Synthesis and characterization of
  申请人：The United States of America as represented by the Department of Health

  公开号：US05169984A1

  公开（公告）日：1992-12-08

  A method for synthesizing N-bromoacetyl-3,3',5-triiodo-L-thyronine which involves subjecting 3,3', 5-triiodo-L-thyronine to a one-step bromacetylation reaction wherein 3,3', 5-triiodo-L-thyronine and bromoacetyl bromide are refluxed together in a solution of ethyl acetate. After formation the N-bromoacetyl-3,3'-triiodo-L-thyronine is purified by fractionation utilizing high speed countercurrent chromatography. Labeled N-bromoacetyl-3,3'-5-triiodo-L-thryonine may be made by a one-step bromacetylation reaction by reducing either [.sup.125 I]T.sub.3 or [.sup.14 C]T.sub.3 with bromoacetyl bromide.

  一种合成N-溴乙酰基-3,3',5-三碘-L-甲状腺素的方法，涉及将3,3'，5-三碘-L-甲状腺素置于乙酸乙酯溶液中，与溴乙酰溴反应进行一步溴乙酰化反应。形成N-溴乙酰基-3,3'-三碘-L-甲状腺素后，通过高速逆流色谱分离纯化。可以通过将[.sup.125 I]T.sub.3或[.sup.14 C]T.sub.3与溴乙酰溴还原反应进行一步溴乙酰化反应来制备标记的N-溴乙酰基-3,3',5-三碘-L-甲状腺素。