N-[2-(Dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenylacetamide--hydrogen chloride (1/1) | 3579-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(Dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenylacetamide--hydrogen chloride (1/1)
• 英文别名: N-[2-(dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenylacetamide;hydrochloride
• CAS: 3579-66-6
• 化学式: C25H37ClN2O2
• 分子量: 433.0
• InChiKey: NNKSRGUMPLVLGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  34
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-甲基-16-氮杂四环[7.6.1.02,7.010,15]十六碳-2,4,6,10,12,14-六烯 、 N-[2-(Dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenylacetamide--hydrogen chloride (1/1) 在 1-甲基-16-氮杂四环[7.6.1.02,7.010,15]十六碳-2,4,6,10,12,14-六烯 、 三(羟甲基)氨基甲烷醋酸盐 作用下， 反应 1082.0h， 生成 地佐环平
  参考文献：
  名称：

  o-Phosphono(alkyl)-N-sulfonyl-phenyl-alanine derivatives useful as

  摘要：

  本文描述了一类磷酸羟基异喹啉化合物，用于治疗与缺氧或缺血相关的神经毒性损伤，通常是中风、心脏骤停或围产期窒息后的损伤。治疗包括单独或在组合物中给予磷酸羟基异喹啉化合物，其有效量作为拮抗剂抑制主要神经元兴奋性氨基酸受体位点的兴奋毒性作用。最感兴趣的化合物是公式I的化合物：##STR1## 其中R1至R4中的每一个都是氢基，Z1和Z2中的每一个都是羟基，W是将磷原子与芳香环连接的单键，A环是芳香的。此外，还披露了两类中间化合物，具有完全不饱和的A环，这些中间化合物在制备公式I的产物化合物的方法中很有用。

  公开号：

  US05177240A1
• 作为试剂：
  描述：

  、 、 3,5-二氯-4-羟基苯乙酮 、 水 在 solution 、 2-羟基丙烷-1,2,3-三羧酸根 、 N-[2-(Dimethylamino)ethyl]-2-(2-ethylbutoxy)-N-methyl-2,2-diphenylacetamide--hydrogen chloride (1/1) 作用下， 生成 2-羟基苯乙酮
  参考文献：
  名称：

  Method for determination of hydroxyacetophenone derivatives

  摘要：

  提供了一种测定羟基乙酰苯酮衍生物（如3,5-二氯-4-羟基乙酰苯酮）在蛋白质（如白蛋白或球蛋白）存在下高灵敏度的方法。该羟基乙酰苯酮衍生物可以在中性至酸性范围内测量，因此该方法不受胆红素或血红蛋白等干扰物的影响。羟基乙酰苯酮衍生物可用作合成底物的显色剂，用于测定酸性磷酸酶活性。

  公开号：

  US05151372A1

文献信息

• Methods and products for the synthesis of oligosaccharide structures on
  申请人：The Regents of the University of Michigan

  公开号：US05595900A1

  公开（公告）日：1997-01-21

  A method for isolating a gene, comprising: (i) isolating a cell possessing a post-translational characteristic of interest, said post-translational characteristic being the presence of a membrane-bound oligosaccharide or polysaccharide of interest on the surface of said cell, the presence of a soluble oligosaccharide or polysaccharide of interest in an extract of said cell, or the presence of a particularly glycosyltransferase activity in an extract of said cell; (ii) creating a genetic library of either cDNA or genomic DNA from the genetic material of said isolated cell; (iii) transforming host cells with said genetic library; and (iv) screening said transformed host cells for a host cell containing said post-translational characteristic, thereby obtaining a cell containing said gene, is disclosed. The method can be used to obtain genes encoding glycosyltransferases.

  一种分离基因的方法，包括：(i)分离具有感兴趣的翻译后特征的细胞，该翻译后特征是所述细胞表面存在感兴趣的膜结合寡糖或多糖、感兴趣的可溶性寡糖或多糖提取物或者感兴趣的特定糖基转移酶活性，(ii)从所述分离的细胞的遗传物质中创建cDNA或基因组DNA的基因库，(iii)将所述基因库转化为宿主细胞，(iv)筛选所述转化的宿主细胞以获取包含所述翻译后特征的宿主细胞，从而获得包含所述基因的细胞。该方法可用于获得编码糖基转移酶的基因。
• Vascular therapeutics
  申请人：Khachigian M. Levon

  公开号：US20050119213A1

  公开（公告）日：2005-06-02

  The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and/or solid tumour growth in a subject The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.

  本发明提供了一种防止或减少受体内再狭窄、新内膜形成、移植物失效、动脉粥样硬化、血管生成和/或实体肿瘤生长的方法。该方法包括向受体注射一种预防性有效剂量的核酸，该核酸降低c-Jun mRNA、c-Jun mRNA翻译或c-Jun的核积累或活性水平。最好的情况是，该核酸是针对c-Jun mRNA的DNA酶。
• Amino acid modified polypeptides
  申请人：United States Surgical Corporation

  公开号：US20040086961A1

  公开（公告）日：2004-05-06

  Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.

  将某些氨基酸类似物纳入通常不含有此类氨基酸类似物的细胞所产生的多肽中，是通过将这些细胞置于含有此类氨基酸类似物的生长培养基中实现的。通过调整培养基中氨基酸类似物的浓度和/或调整渗透压，可以调节纳入的程度。这种纳入使得多肽的化学和物理特性得以改变和研究。此外，还提供了含有来自生理活性肽和能够提供自聚的细胞外基质蛋白质的核酸和相应的蛋白质。由原核细胞产生的能够提供自聚胶原的人类细胞外基质蛋白质也被提供。在原核生物中，采用了优选的密码子使用来产生细胞外基质蛋白质。
• Hydrophobically-modified protein compositions and methods
  申请人：Pepinsky Blake R.

  公开号：US20050119181A1

  公开（公告）日：2005-06-02

  Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

  描述了一种水疏性修饰蛋白质及其制备方法。将一种疏水基团附加到蛋白质的表面氨基酸残基上。该疏水基团可以是脂质或肽。或者，可以通过各种化学反应使蛋白质衍生出一个疏水结构。优选的蛋白质是哺乳动物来源的，并从Sonic，Indian和Desert hedgehog组中选择。该疏水基团可用作方便的系链，可附着细胞膜、脂质体或微胶束等载体。
• Plant fatty acid synthases
  申请人：Calgene Inc.

  公开号：US05475099A1

  公开（公告）日：1995-12-12

  By this invention, compositions and methods of use related to .beta.-ketoacyl-ACP synthase, hereinafter also referred to as "synthase", are provided. Also of interest are methods and compositions of amino acid and nucleic acid sequences related to biologically active plant synthase(s). In particular, synthase protein preparations which have relatively high turnover (specific activity) are of interest for use in a variety of applications, in vitro and in vivo. Especially, protein preparations having synthase I and/or synthase II activities are contemplated hereunder. Synthase activities are distinguished by the preferential activity towards longer and shorter acyl-ACPs. Protein preparations having preferential activity towards shorter chain length acyl-ACPs are synthase I-type. Synthases having preferential activity towards longer chain length acyl-ACPs are synthase II-type. Of special interest are synthases obtainable from Ricinus communis.

  本发明提供了与β-酮酰基-ACP合酶相关的组合物和使用方法，以下简称“合酶”。还包括与生物活性植物合酶相关的氨基酸和核酸序列的方法和组合物。特别是对于具有相对较高周转率（特异活性）的合酶蛋白制备，在体外和体内的各种应用中具有兴趣。特别是，考虑到合酶I和/或合酶II活性的蛋白质制剂。合酶活性通过对长链和短链酰基-ACP的优先活性来区分。具有对短链酰基-ACP具有优先活性的蛋白质制剂是合酶I型。对长链酰基-ACP具有优先活性的合酶是合酶II型。特别感兴趣的是从蓖麻中获得的合酶。