N-(7-氟-9H-芴-2-基)乙酰胺 | 343-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: N-(7-氟-9H-芴-2-基)乙酰胺
• 英文名称: N-2-<7-Fluor-fluorenyl>-acetamid
• 英文别名: N-(7-fluoro-fluoren-2-yl)-acetamide；N-(7-Fluor-fluoren-2-yl)-acetamid；2-acetamido-7-fluorofluorene；7-Fluoro-2-acetylaminofluorene；N-(7-fluoro-9H-fluoren-2-yl)acetamide
• CAS: 343-89-5
• 化学式: C₁₅H₁₂FNO
• 分子量: 241.265
• InChiKey: UAGZFYAGROGZQW-UHFFFAOYSA-N

物化性质

• 密度：
  1.1990 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(7-氟-9H-芴-2-基)乙酰胺 在 盐酸 、 tetrafluoroboric acid 、 sodium dichromate 、 硝酸 、 tin(ll) chloride 、 sodium nitrite 作用下， 以 溶剂黄146 、 二甲基亚砜 为溶剂， 生成 7-Fluor-3-diazonio-9-oxo-fluoren
  参考文献：
  名称：

  芴的衍生物。23.与致癌物N-2-芴基乙酰胺代谢有关的新的硫芴。

  摘要：

  DOI：

  10.1021/jm00317a041

文献信息

• Derivatives of Fluorene. XVIII. New Halogenofluorenes. I. Potential Antitumor Agents^1,2
  作者：Hsi-lung Pan、T. Lloyd Fletcher

  DOI：10.1021/jm00331a008

  日期：1964.1
• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• [EN] MULTI-STAGE STEM CELL CARCINOGENESIS<br/>[FR] CARCINOGENESE DE CELLULES SOUCHES MULTIETAPES
  申请人：STEMLIFELINE INC

  公开号：WO2010037134A2

  公开（公告）日：2010-04-01

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• Derivatives of Fluorene. XXIII.¹ New Thiofluorenes Related to Metabolism of the Carcinogen N-2-Fluorenylacetamide
  作者：T. Lloyd. Fletcher、Moses J. Namkung、Hsi-Lung. Pan

  DOI：10.1021/jm00317a041

  日期：1967.9