4-(6-Methyl-2-pyridyl)butanal | 46119-04-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(6-Methyl-2-pyridyl)butanal
• 英文别名: 4-(6-methyl-pyridin-2-yl)-butyraldehyde；4-(6-Methyl-2-pyridinyl)butanal；4-(6-methylpyridin-2-yl)butanal
• CAS: 46119-04-4
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: OWSBEHDDCSXORC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(6-Methyl-2-pyridyl)butanal 在 正丁基锂 、 乙醇 、 sodium 作用下， 以 四氢呋喃 为溶剂， 反应 25.0h， 生成 trans-2-Methyl-6-(Z,4-nonenyl)piperidine
  参考文献：
  名称：

  Chemistry of venom alkaloids in someSolenopsis (Diplorhoptrum) species from Puerto Rico

  摘要：

  A number of 15-carbon alkaloids have been identified in venom extracts of four Puerto Rican species of ants in the genus Solenopsis (Diplorhoptrum). Workers of a species from El Verde produced the cis and trans isomers of 2-methyl-6-nonylpiperidine with the latter isomer predominating. The same compounds were identified in queens of a species from Rio Grande, but in this species no alkaloids were detected in worker extracts. Workers of a Diplorhoptrum species collected on Mona Island produced primarily a trans-2-methyl-6-(Z-4-nonenyl)piperidine, 3, with smaller amounts of the cis isomer, whereas the major compound found in the queens of the same species on Mona Island was (5Z,9Z)-3-hexyl-5-methylindolizidine, identical with the alkaloid produced by queens of a species collected on Cabo Rojo. Surprisingly, workers of the Cabo Rojo species produced (5Z,9Z)- and (5E,9E)-3-butyl-5-propylindolizidine (4 and 5, respectively) reported earlier as the 223AB indolizidines from skins of dendrobatid frogs. The possible significance of the qualitative and quantitative differences in the venom alkaloids synthesized by queens and workers is discussed as is the possibility that ants containing such alkaloids may serve as a dietary source for the skin alkaloids used by certain frogs in chemical defense.

  DOI：

  10.1007/bf02266962
• 作为产物：
  描述：

  2-[3-(6-methyl-2-pyridyl)-propyl]-1,3-dioxolane 在 盐酸 、 水 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 1.5h， 以3.5 g的产率得到4-(6-Methyl-2-pyridyl)butanal
  参考文献：
  名称：

  Chemistry of venom alkaloids in someSolenopsis (Diplorhoptrum) species from Puerto Rico

  摘要：

  A number of 15-carbon alkaloids have been identified in venom extracts of four Puerto Rican species of ants in the genus Solenopsis (Diplorhoptrum). Workers of a species from El Verde produced the cis and trans isomers of 2-methyl-6-nonylpiperidine with the latter isomer predominating. The same compounds were identified in queens of a species from Rio Grande, but in this species no alkaloids were detected in worker extracts. Workers of a Diplorhoptrum species collected on Mona Island produced primarily a trans-2-methyl-6-(Z-4-nonenyl)piperidine, 3, with smaller amounts of the cis isomer, whereas the major compound found in the queens of the same species on Mona Island was (5Z,9Z)-3-hexyl-5-methylindolizidine, identical with the alkaloid produced by queens of a species collected on Cabo Rojo. Surprisingly, workers of the Cabo Rojo species produced (5Z,9Z)- and (5E,9E)-3-butyl-5-propylindolizidine (4 and 5, respectively) reported earlier as the 223AB indolizidines from skins of dendrobatid frogs. The possible significance of the qualitative and quantitative differences in the venom alkaloids synthesized by queens and workers is discussed as is the possibility that ants containing such alkaloids may serve as a dietary source for the skin alkaloids used by certain frogs in chemical defense.

  DOI：

  10.1007/bf02266962

文献信息

• MACROLIDE LHRH ANTAGONISTS
  申请人：ABBOTT LABORATORIES

  公开号：EP1066304A1

  公开（公告）日：2001-01-10
• US5955440A
  申请人：——

  公开号：US5955440A

  公开（公告）日：1999-09-21
• [EN] MACROLIDE LHRH ANTAGONISTS<br/>[FR] ANTAGONISTES MACROLIDES DE L'HORMONE DE LIBERATION DE LA LUTEINOSTIMULINE (LHRH)
  申请人：——

  公开号：WO1999050275A2

  公开（公告）日：1999-10-07

  [EN] Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.
  [FR] L'invention concerne des dérivés de l'érythromycine A sous forme de carbamate cyclique de 3'-N-desméthyl-3'N-6-O-méthyl substitué-11-déoxy-11,12, qui sont des antagonistes de l'hormone de libération de la lutéinostimuline (LHRH). L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des techniques d'utilisation de ces composés et le procédé de fabrication de ces composés.