2,6-Dioxohexanoic acid | 98136-15-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2,6-Dioxohexanoic acid
• CAS: 98136-15-3
• 化学式: C₆H₈O₄
• mdl: MFCD19231159
• 分子量: 144.127
• InChiKey: HNXZYFSZUNUDPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-hydroxymuconic 6-semialdehyde 在 HOPDA reducing enzyme 还原型辅酶II(NADPH)四钠盐 作用下， 生成 2,6-Dioxohexanoic acid
  参考文献：
  名称：

  Omori, Toshio; Ishigooka, Hiroshi; Minoda, Yasuji, Agricultural and Biological Chemistry, 1986, vol. 50, # 6, p. 1513 - 1518

  摘要：

  DOI：

文献信息

• 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
  申请人：BARBOSA Joseph

  公开号：US20120302562A1

  公开（公告）日：2012-11-29

  Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

  描述了可以用来抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物，以及它们用于治疗影响骨骼的疾病和紊乱的方法。
• BIOFUEL PRODUCTION
  申请人：Yoshikuni Yasuo

  公开号：US20090139134A1

  公开（公告）日：2009-06-04

  Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。
• BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS
  申请人：Baynes Brian M.

  公开号：US20120301950A1

  公开（公告）日：2012-11-29

  Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

  本文提供了在微生物中生产双官能基烷烃的方法。同时还提供了编码这种酶的核酸和酶，与从碳水化合物饲料中生产双官能基烷烃相关。本发明还提供了重组微生物和代谢途径，用于生产双官能基烷烃。
• METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETIDINONE COMPOUND
  申请人：Zhejiang Hisun Pharmaceutical Co., Ltd.

  公开号：EP3153496A1

  公开（公告）日：2017-04-12

  Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.

  本发明公开了一种制备式 (I) 所代表的氮杂环丁酮化合物的新方法。以式（II）代表的羧基酮酯为原料，经过格氏加成、立体选择性脱水、酯基还原、羟基保护、与手性助剂缩合后与亚胺加成、环化和脱保护得到式（I）代表的化合物。本发明具有原料易得、合成步骤少、操作简单、收率高、立体选择性好、成本低等优点，可用于工业生产。
• INKS INCLUDING BLOCK COPOLYMER GRAFTED PIGMENTS VIA AZIDE CHEMISTRY
  申请人：Zhou Zhang-Lin

  公开号：US20120300284A1

  公开（公告）日：2012-11-29

  Pigment based inks are provided. The inks include a non-polar carrier fluid; and a surface-functionalized pigment particle including a nitrogen-inked moiety to the surface of the pigment particle through a nitrogen link at one end of the nitrogen-linked moiety and a block copolymer having at least two blocks attached at another end, the pigment particle suspended in the non-polar carrier fluid. A combination of an electronic display and an electronic ink employing the pigment and a process for making the pigment-based inks are also provided.