N'-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine | 570416-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N'-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine
• 英文别名: N'-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-yl)sulfonyl-N,N-bis(2-methylpropyl)methanimidamide
• CAS: 570416-10-3
• 化学式: C₁₈H₂₆ClN₅O₂S
• 分子量: 411.956
• InChiKey: PJDXAHLWMPCUAA-RGVLZGJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N'-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 15.0h， 以50.4%的产率得到2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonamide
  参考文献：
  名称：

  FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME

  摘要：

  公开号：

  EP1466527B1
• 作为产物：
  描述：

  N'-(2,6-dichloroimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine 、 环丙基溴化镁 在 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) zinc(II) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 18.25h， 以45.7%的产率得到N'-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine
  参考文献：
  名称：

  FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME

  摘要：

  公开号：

  EP1466527B1

文献信息

• Novel process for producting imidazo[1,2-b]pyridazine derivative
  申请人：Tabuchi Takanori

  公开号：US20050171108A1

  公开（公告）日：2005-08-04

  A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO 2 N═CH—NR 1 R 2 ; and Z represents halogeno or OSO 2 R 3 ) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.

  一种用于简便、低成本地生产具有取代基与6-位碳原子键合的咪唑[1,2-b]吡嗪-3-基磺酰胺衍生物的方法，其化学式表示为(II):(其中R代表低烷基、低环烷基(可选地被低烷基取代)、低烯基或低炔基)，该方法包括在过渡金属催化剂的存在下，将咪唑[1,2-b]吡嗪化合物与有机金属化合物反应，所述咪唑[1,2-b]吡嗪化合物的化学式表示为(I):(其中X代表卤素或低烷基(可选地被卤素取代)；Y代表氢或SO2N═CH—NR1R2；Z代表卤素或OSO2R3)。该衍生物可用作除草剂的中间体。
• Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20050032650A1

  公开（公告）日：2005-02-10

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种由以下式子表示的化合物：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代低烷基，可选的卤代低烷氧基等，或其盐，以及包含该化合物或其盐的除草剂，在稻田中对磺酰脲除草剂耐药杂草具有显著的控制效果，可以减少联合制剂中的活性成分数量，并且包括使用该化合物的控制磺酰脲除草剂耐药杂草的方法。
• Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20100160163A1

  公开（公告）日：2010-06-24

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种化合物，其表示为公式：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代较低烷基基团，可选的卤代较低烷氧基团等，或其盐，以及包含该化合物或其盐的除草剂，该除草剂对水稻田中的磺酰脲除草剂抗性杂草具有显着的控制效果，并且可以减少组合制剂中活性成分的数量，以及使用该化合物来控制磺酰脲除草剂抗性杂草的方法。
• NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE
  申请人：Sumitomo Chemical Takeda Agro Company, Limited

  公开号：EP1541575A1

  公开（公告）日：2005-06-15

  A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO2N=CH-NR1R2; and Z represents halogeno or OSO2R3) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.

  一种简便廉价地生产咪唑并[1,2-b]哒嗪-3-基磺酰胺衍生物的工艺，该衍生物具有键合在 6 位碳原子上的取代基，由式(II)表示： (其中 R 代表低级烷基、任选被低级烷基、低级烯基或低级炔基取代的低级环烷基)，该过程包括使由式(I)代表的咪唑并[1,2-b]哒嗪化合物反应： (其中 X 代表卤素或任选被卤素取代的低级烷基；Y 代表氢或 SO2N=CH-NR1R2；Z 代表卤素或 OSO2R3）与有机金属化合物在过渡金属催化剂存在下反应。该衍生物可用作除草剂的中间体。
• US7307165B2
  申请人：——

  公开号：US7307165B2

  公开（公告）日：2007-12-11