bis(3,4,5-trimethoxybenzyl) ether | 68299-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(3,4,5-trimethoxybenzyl) ether
• 英文别名: 1,1'-[Oxybis(methylene)]bis(3,4,5-trimethoxybenzene)；1,2,3-trimethoxy-5-[(3,4,5-trimethoxyphenyl)methoxymethyl]benzene
• CAS: 68299-87-6
• 化学式: C₂₀H₂₆O₇
• 分子量: 378.422
• InChiKey: RNIYRJCVGUZXSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  bis(3,4,5-trimethoxybenzyl) ether 在 三氟化硼乙醚 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以38%的产率得到1,2,3,9,10,11-hexamethoxy-5,7-dihydrodibenzoxepine
  参考文献：
  名称：

  Oxidative Biaryl Coupling Reaction of Phenol Ether Derivatives Using a Hypervalent Iodine(III) Reagent

  摘要：

  The hypervalent iodine(III)-induced intramolecular biaryl coupling reaction of phenol ether derivatives (nonphenolic derivatives) was investigated with the aim of preparing various dibenzo heterocyclic compounds. 1,3-Diarylpropanes (1a-e), N-benzyl-N-phenethylamines (2a-c) and N,N-dibenzylamines (3a-e) react with a hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA), containing BF3. Et2O in CH2Cl2 to give the biaryl coupling products (4-6) in good yield. As an application of the reaction, we examined the synthesis of oxygen- and sulfur-containing dibenzoheterocyclic compounds (12-15), whose side chain moiety could be easily cleaved by the known method to give 2,2'-substituted biphenyl compounds (16-18).

  DOI：

  10.1021/jo980704f
• 作为产物：
  描述：

  3,4,5-三甲氧基苄醇 在 proton exchanged montmorillonite 作用下， 以 二氯甲烷 为溶剂， 以6%的产率得到bis(3,4,5-trimethoxybenzyl) ether
  参考文献：
  名称：

  Unusual transformation of 4-hydroxy/methoxybenzylic alcohols via C C ipso-substitution reaction using proton-exchanged montmorillonite as media

  摘要：

  We present here proton-exchanged montmorillonite-mediated an unusual transformation of 4-hydroxy and 4-methoxybenzylic alcohols to form symmetrical benzylic ethers and diarylmethanes under mild conditions. Nuclear magnetic resonance spectroscopy and density functional theory calculations support a plausible mechanism, which includes a distinctive aromatic C-C ipso-substitution reaction with a hydroxymethyl group as the C-based leaving group. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2020.152584

文献信息

• [EN] STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES<br/>[FR] PROCÉDÉ STÉRÉOSÉLECTIF DE FABRICATION DE PHOSPHORAMIDATES DE PURINE
  申请人：ATEA PHARMACEUTICALS INC

  公开号：WO2021216722A1

  公开（公告）日：2021-10-28

  The present invention provides stereoselective processes of manufacture for the phosphoramidate nucleotide Compound 1 or a pharmaceutically acceptable salt thereof.

  本发明提供了制备磷酰胺酰核苷化合物1或其药学上可接受的盐的立体选择性制造过程。
• Bis-imidazolinoamino derivatives as useful antiallergy compounds
  申请人：USV PHARMACEUTICAL CORPORATION

  公开号：EP0187989A1

  公开（公告）日：1986-07-23

  Compounds of the formula: and pharmaceutically acceptable salts thereof; wherein Ar, is phenyl, naphthyl, or a nitrogen, oxygen or sulfur heterocyclic ring; X and Y are independently O, S or a chemical bond; Z, and Z3 are each a chemical bond or alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms; Z2 and Z4 are each chemical bond, alkylene chain containing up to 6 carbon atoms in the principal chain and a total of up to 10 carbon atoms, aryl, cycloalkyl, or a nitrogen, oxygen, sulfur heterocyclic ring; each R, is independently hydrogen, lower alkyl, aryl, lower aralkyl, hydroxy, lower alkoxy, carboxy, lower carbalkoxy, lower carbaralkoxy, lower carbaryloxy, lower alkoxy carbonyl, lower alkanoyl, cyano, halogen, amino loweralkylmercapto, lower alkenyl, lower alkynyl, lowercycloalkyl. R2, R5, R7, R9 and R13 are independently hydrogen, lower alkyl or lower alkanoyl; but when the nitrogen to which R2 is attached contains a double bond, then R2 is -, when the nitrogen to which R9 is attached contains a double bond, then R9 is-, or when the nitrogen to which R,3 is attached contains a double bond, then R,3 is-; then R,3 is -; R3, R4, R6 and R8 are independently hydrogen, lower alkyl, cyano, or nitro; R11 and R,2 are independently hydrogen, or lower alkyl; n is 0, 1, 2, or 3 and m is 0, 1, or 2; provided that when Z2 is a chemical bond or methylene group, X and Y cannot be toth oxygen or sulfur simul- taneousty.

  式化合物 及其药学上可接受的盐； 其中 Ar 是苯基、萘基或氮、氧或硫杂环； X 和 Y 独立地为 O、S 或化学键 Z和Z3各自是化学键或亚烷基链，在主链中最多含有6个碳原子，总共最多含有10个碳原子； Z2和Z4各自是化学键、主链中最多含有6个碳原子且总共最多含有10个碳原子的亚烷基链、芳基、环烷基或氮、氧、硫杂环； 每个 R 独立地是氢、低级烷基、芳基、低级芳烷基、羟基、低级烷氧基、羧基、低级碳烷氧基、低级碳烷氧基、低级碳酰氧基、低级烷氧基羰基、低级烷酰基、氰基、卤素、氨基、低级烷巯基、低级烯基、低级炔基、低级环烷基。 R2、R5、R7、R9 和 R13 独立地为氢、低级烷基或低级烷酰基；但当 R2 所连接的氮含有双键时，则 当 R2 所连接的氮含有双键时，R2 为-；当 R9 所连接的氮含有双键时，R9 为-；或当 R,3 所连接的氮含有双键时，R,3 为-；则 R,3 为-； R3、R4、R6 和 R8 独立地为氢、低级烷基、氰基或硝基； R11 和 R,2 独立地为氢或低级烷基； n 是 0、1、2 或 3，以及 m 为 0、1 或 2； 但当 Z2 是化学键或亚甲基时，X 和 Y 不能是氧或硫的同素异形体。
• Salmon Manuel, Zavala Nieves, Martinez Mariano, Miranda Rene, Cruz Raymun+, Tetrahedron Lett, 35 (1994) N 32, S 5797-5800
  作者：Salmon Manuel, Zavala Nieves, Martinez Mariano, Miranda Rene, Cruz Raymun+

  DOI：——

  日期：——
• Cyclic and linear oligomerization reaction of 3,4,5-trimethoxybenzyl alcohol with a bentonite-clay
  作者：Manuel Salmón、Nieves Zavala、Mariano Martínez、René Miranda、Raymundo Cruz、Jorge Cárdenas、Rubén Gaviño、Armando Cabrera

  DOI：10.1016/s0040-4039(00)78187-1

  日期：1994.8

  The catalytic induction and structures of cyclic and linear oligomers from 3,4,5-trimethoxybenzyl alcohol with a bentonite clay as catalyst are discussed.
• US4889868A
  申请人：——

  公开号：US4889868A

  公开（公告）日：1989-12-26