uvinul 2088

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: uvinul 2088
• 英文别名: (E)-octyl 3-(4-methoxyphenyl)acrylate；octyl para-methoxycinnamate；n-octyl p-methoxycinnamate；octyl methoxycinnamate；octyl p-methoxy cinnamate；2-Propenoic acid, 3-(4-methoxyphenyl)-, octyl ester；octyl (E)-3-(4-methoxyphenyl)prop-2-enoate
• 化学式: C₁₈H₂₆O₃
• 分子量: 290.403
• InChiKey: PCQLCJLFQGMYHD-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  反式-4-甲氧基肉桂酸 在 碘 、 zinc trifluoromethanesulfonate 作用下， 以 乙腈 为溶剂， 反应 4.67h， 生成 uvinul 2088
  参考文献：
  名称：

  Zn(OTf)₂-Promoted Chemoselective Esterification of Hydroxyl Group Bearing Carboxylic Acids

  摘要：

  Selective esterification of aliphatic and aromatic carboxylic acids with various alcohols is studied using triphenylphosphine, I-2, and a catalytic amount of Zn(OTf)(2). Use of this catalyst allows the formation of esters at a faster rate with good to excellent yield by activating the in situ generated acyloxyphosphonium ion intermediate. During the esterification process, both their aromatic and aliphatic hydroxyl groups are fully preserved from trans-esterification. The results show that the bulkiness and the reactivity of this doubly activated intermediate III control the selectivity and the rate of the reaction, respectively. The method is also useful for direct amidation reactions.

  DOI：

  10.1021/jo302502r

文献信息

• Use of Mineral/Organic Composite Material in the Form of an Ultraviolet Radiation Protective Agent
  申请人：Daniele Stephane

  公开号：US20090104135A1

  公开（公告）日：2009-04-23

  The invention relates to the use of composite material which comprises nanoparticles of a least one metal derivative and at least one organic sunscreen agent which is chemically bound with said particles in a covalent manner in the form of an ultraviolet radiation protective agent containing the inventive composite material. Cosmetic ultraviolet radiation protective compositions comprises said mixture are also disclosed.

  该发明涉及使用复合材料，该复合材料包括至少一种金属衍生物的纳米颗粒和至少一种有机防晒剂，该有机防晒剂以共价方式与所述颗粒化学结合，形成一种含有所述创新复合材料的紫外辐射防护剂。还公开了包含所述混合物的化妆品紫外辐射防护组合物。
• Inverse latex of anionic polyelectrolytes in silicone oils; cosmetic use thereof
  申请人：SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES, S.E.P.P.I.C.

  公开号：EP1932515A1

  公开（公告）日：2008-06-18

  Composition comprising an oil phase, an aqueous phase, at least one emulsifying system of water-in-oil (W/O) type, optionally at least one emulsifying system of oil-in-water (O/W) type, in the form of an inverse latex comprising from 10% to 80% by mass and preferably from 20% to 70% by mass and most preferably from 30% to 60% by mass, of a linear partially or totally salified anionic polyelectrolyte, with wherein in that said oil phase comprises a silicone oil or a mixture of silicone oils; its use to thicken and or to emulsify cosmetic, dermopharmaceutical or pharmaceutical compositions.

  包括油相、水相、至少一种水包油（W/O）型乳化系统、可选地至少一种油包水（O/W）型乳化系统的组合物，以反向乳胶的形式，包括质量百分含量为10%至80%，优选为20%至70%，最优选为30%至60%的线性部分或完全盐化的阴离子聚电解质；其中所述油相包括硅油或硅油混合物；其用途是用于增稠和/或乳化化妆品、皮肤药物或药用组合物。
• Novel inverse latices of copolymers of AMPS and of N,N-dimethylacrylamide; cosmetic use
  申请人：Braun Olivier

  公开号：US20060269490A1

  公开（公告）日：2006-11-30

  Composition including an oil phase, an aqueous phase, at least one emulsifying system of water-in-oil (W/O) type, optionally at least one emulsifying system of oil-in-water (O/W) type, in the form of an inverse latex including from 20% to 70% by mass and preferably from 25% to 50% by mass of a branched or crosslinked polyelectrolyte, characterized in that the polyelectrolyte is a copolymer of 2-acrylamido-2-methylpropanesulfonic acid partially or totally salified with N,N-dimethylacrylamide and optionally one or more monomers chosen from monomers containing a partially or totally salified weak acid function and neutral monomers. Cosmetic use.

  包括油相、水相、至少一种水包油（W/O）型乳化系统、可选地至少一种油包水（O/W）型乳化系统的组合物，呈逆乳胶形式，包括质量百分含量为20%至70%，优选为25%至50%的支化或交联聚电解质，其特征在于聚电解质是2-丙烯酰胺基-2-甲基丙烯磺酸与N,N-二甲基丙烯酰胺部分或完全盐化的共聚物，可选地还包括从含部分或完全盐化弱酸功能的单体和中性单体中选择的一个或多个单体。用于化妆品。
• Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same
  申请人：Nishihama Shuji

  公开号：US20080081029A1

  公开（公告）日：2008-04-03

  To provide surface-treating agents that can provide excellent hydrophobicity to powder and can improve its rinsability, to provide surface-treated powders that are treated with the surface-treating agent, and to provide cosmetics that comprise the surface-treated powder. A surface-treating agent consisting of a polymer which comprises a monomer (A) represented by the general formula (1) described below as a constituent monomer. (wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R 2 represents an alkylene group having 4 to 22 carbon atoms, X 1 represents an —NH— group or an oxygen atom, and M 1 represents a hydrogen atom or a monovalent inorganic or organic cation.)

  提供能够为粉末提供出色疏水性并改善其可冲洗性的表面处理剂，提供经表面处理剂处理的粉末，以及提供包含经表面处理的粉末的化妆品。一种表面处理剂，由包含下述通用式（1）所描述的单体（A）作为组分单体的聚合物组成。 （其中R1代表氢原子或具有1至3个碳原子的烷基基团，R2代表具有4至22个碳原子的烷基基团，X1代表—NH—基团或氧原子，M1代表氢原子或一价无机或有机阳离子。）
• [EN] TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME<br/>[FR] COMPOSÉS DE DÉRIVÉS DE TRÉPROSTINIL ET LEURS PROCÉDÉS D'UTILISATION
  申请人：CORSAIR PHARMA INC

  公开号：WO2016010538A1

  公开（公告）日：2016-01-21

  Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

  由I、II、III和IV式代表的化合物包括曲前列素和前列环素类似物的前药。用途包括治疗肺动脉高压（PH）或肺动脉高压（PAH）。这些化合物的结构可以根据适当的治疗剂量调整以适应特定的应用。可以使用经皮应用。