4-(methylsulfinyl)diphenyl sulfide | 33689-38-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-(methylsulfinyl)diphenyl sulfide
• 英文别名: methyl(p-thiophenoxy)phenyl sulfoxide；1-methylsulfinyl-4-phenylsulfanylbenzene
• CAS: 33689-38-2
• 化学式: C₁₃H₁₂OS₂
• 分子量: 248.37
• InChiKey: JPWMOMLZYHIDLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  61.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲硫基苯硫醇 在 双氧水 、 铜 、 potassium carbonate 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-(methylsulfinyl)diphenyl sulfide
  参考文献：
  名称：

  Potential metabolites of the neuroleptic agents belonging to the 8-methylthio-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin series; Synthesis of 2-hydroxy and 3-hydroxy derivatives

  摘要：

  通过在铜的存在下，将(2-碘-5-甲氧基苯基)乙酸和4-(甲硫基)噻吩的钾盐反应制备的酸VI，通过中间体VII-IX转化为2-甲氧基-8-甲硫基-10-哌嗪基-10,11-二氢二苯并[b,f]噻吩X和XI。它们经过硼三溴化物去甲基化后形成神经阻滞剂甲硫噻噻嗪和氧普噻噻嗪的2-羟基衍生物I和II。11-氯-7-甲氧基-2-甲硫基-10,11-二氢二苯并[b,f]噻噻嗪经过与1-甲基哌嗪和1-(乙氧羰基)哌嗪的取代反应，形成哌嗪衍生物XIII和XIV，其中后者通过碱性水解形成二级胺XV。醚化合物XIII和XV也可以用硼三溴化物裂解，形成甲硫噻噻嗪（III）及其去甲基衍生物IV的3-羟基衍生物。酚类化合物I、II和IV是所述神经阻滞剂的潜在代谢产物；已被鉴定为代谢产物的化合物III具有强烈的和短暂的神经阻滞剂效应。甲氧基化合物X、XI和XIII几乎没有神经阻滞活性。

  DOI：

  10.1135/cccc19852179

文献信息

• METHOD FOR PREPARING COMPOUND AND METHOD FOR PREPARING POLYMER EMPLOYING THE SAME
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20190040202A1

  公开（公告）日：2019-02-07

  A method for preparing a compound and a method for preparing a polymer employing the same are provided. The method for preparing a compound includes reacting a compound having a structure represented by Formula (I) with a compound having a structure represented by Formula (III) in the presence of a compound having a structure represented by Formula (II) to obtain a compound having a structure represented by Formula (IV) wherein Ar 1 is substituted or unsubstituted aryl group; X is —O—, —S—, or —NH—; R 1 is independently hydrogen or C 1-6 alkyl group; R 2 is hydroxyl group, C 1-6 alkyl group, phenyl group, or tolyl group; and R 3 is independently C 1-6 alkyl group, C 5-8 cycloalkyl group, or C 2-6 alkoxyalkyl group.

  提供了一种制备化合物和一种采用该化合物制备聚合物的方法。制备化合物的方法包括在具有式(I)表示的结构的化合物与具有式(III)表示的结构的化合物在具有式(II)表示的结构的化合物存在下反应，以获得具有式(IV)表示的结构的化合物，其中Ar1是取代或未取代的芳基团；X是—O—，—S—或—NH—；R1独立地是氢或C1-6烷基基团；R2是羟基，C1-6烷基基团，苯基或甲苯基；R3独立地是C1-6烷基基团，C5-8环烷基基团或C2-6烷氧基烷基基团。
• AMIDE DERIVATIVE
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP2119702A1

  公开（公告）日：2009-11-18

  The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, -(CH2)sO-, - (CH2)sN(R4)CO-, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

  本发明涉及一种可用作肾素抑制剂的式 (I) 化合物或其药学上可接受的盐。 其中 R1a 是氢原子、任选取代的 C1-6 烷基等；R1b 是任选取代的 C1-6 烷氧基等；R1c 是氢原子、任选取代的 C1-6 烷氧基等；R2 是氢原子、任选取代的 C1-6 烷基等；R3a、R3b、R3c 和 R3d 独立地相同或不同，且各自是式中的基团：-A-B（其中 A 是单键、-(CH2)sO-、-(CH2)sN(R4)CO- 等，B 是氢原子、任选取代的 C1-6 烷基等）等；R4 是氢原子、任选取代的 C1-6 烷基等；s 是 0 等；n 是 1 等。
• METHOD FOR PREPARING POLYARYLENE SULFIDE (PAS) MONOMER
  申请人：Industrial Technology Research Institute

  公开号：EP3190142A1

  公开（公告）日：2017-07-12

  A method for preparing a cationic sulfoxide intermediate having the following formula (1): wherein Ar1 and Ar2 are substituted or unsubstituted aryl groups that are the same or different, includes reacting hydrogen peroxide with (i) a compound having the following formula (2) or sulfonic acid R'SO3H, wherein R' is CH3, CF3, phenyl, toluene, or OH, and (ii) a cationic thioether intermediate having the following formula (4) to obtain the cationic sulfoxide intermediate: wherein R is a substituted or unsubstituted C1-C6 alkyl group; and wherein Ar1 and Ar2 are as defined above and Y is an anion.

  一种具有下式(1)的阳离子亚砜中间体的制备方法： 其中 Ar1 和 Ar2 是相同或不同的取代或未取代的芳基，包括将过氧化氢与(i) 下式（2）的化合物或磺酸 R'SO3H（其中 R'是 CH3、CF3、苯基、甲苯或 OH）和(ii) 下式（4）的阳离子硫醚中间体反应，得到阳离子亚砜中间体： 其中 R 是取代或未取代的 C1-C6 烷基；以及 其中 Ar1 和 Ar2 如上定义，Y 为阴离子。
• POLYMERIZATION PROCESS OF POLYARYLENE SULFIDE
  申请人：Industrial Technology Research Institute

  公开号：EP3190143A1

  公开（公告）日：2017-07-12

  A method for preparing a polyarylene sulfide includes reacting a methyl 4-(arylthio)aryl sulfoxide compound with sulfuric acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid or trifluoromethanesulfonic acid to obtain a polysulfonium intermediate; and demethylating the polysulfonium intermediate to obtain a polyarylene sulfide, wherein the polysulfonium intermediate is demethylated with aqueous HCl, HBr, or HI.

  一种制备聚芳硫醚的方法包括：将 4-(芳硫基)芳基亚砜甲基化合物与硫酸、甲磺酸、苯磺酸、对甲苯磺酸或三氟甲磺酸反应，得到多锍中间体；将多锍中间体脱甲基化，得到聚芳硫醚，其中多锍中间体用 HCl、HBr 或 HI 水溶液脱甲基化。
• POLYARYLENE SULFIDE RESIN, METHOD FOR PRODUCING SAME, POLY(ARYLENE SULFONIUM SALT), AND METHOD FOR PRODUCING POLY(ARYLENE SULFONIUM SALT)
  申请人：DIC Corporation

  公开号：EP3263625A1

  公开（公告）日：2018-01-03

  Disclosed is a production method comprising a step of obtaining a poly(arylene sulfonium salt) comprising a terminal group including at least one functional group selected from the group consisting of a carboxy group, a hydroxy group and an amino group, and a step of dealkylating or dearylating the poly(arylene sulfonium salt) to obtain a polyarylene sulfide resin, and a polyarylene sulfide resin comprising a terminal group including a functional group obtainable by the production method.

  本发明公开了一种生产方法，该方法包括获得聚芳基锍盐的步骤，该聚芳基锍盐包含一个末端基团，该末端基团包含至少一个官能团，该官能团选自由羧基、羟基和氨基组成的组，以及对该聚芳基锍盐进行脱烷基化或脱芳基化以获得聚芳基硫醚树脂的步骤，以及一种聚芳基硫醚树脂，该树脂包含一个末端基团，该末端基团包含一个可通过该生产方法获得的官能团。