N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine | 790633-35-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine
• 英文别名: 2-[2-(2-Aminoethylamino)ethylamino]-3-phenylmethoxypropanoic acid
• CAS: 790633-35-1
• 化学式: C₁₄H₂₃N₃O₃
• 分子量: 281.355
• InChiKey: YMYRUBKWHRAKJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  96.6
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine 、 氯乙酸 在 盐酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 4-羧基-5,8,11-三(羧甲基)-1-苯基-2-氧杂-5,8,11-三氮杂十三烷-13-酸
  参考文献：
  名称：

  PROCESS FOR THE PURIFICATION OF POLYAMINOCARBOXYLATES

  摘要：

  本发明涉及一种改进的聚氨基羧酸盐（如DOTA、DTPA、DO3A-butrol、BOPTA）的纯化过程。

  公开号：

  US20140323719A1

文献信息

• Process for the preparation of contrast agents
  申请人：BRACCO IMAGING S.p.A.

  公开号：EP1762563A1

  公开（公告）日：2007-03-14

  The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

  本发明涉及一种通过在适当的烷基化剂和碱存在下发生羧甲基化反应来制备式(I)化合物的方法，无需监测反应环境的pH。式(I)化合物是制备MRI技术的诊断造影剂的有用中间体。
• Process for the Preparation of Contrast Agents
  申请人：Ceragioli Silvia

  公开号：US20090118537A1

  公开（公告）日：2009-05-07

  The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

  本发明涉及一种制备式(I)化合物的过程，该过程通过在适当的烷基化剂和碱的存在下发生羧甲基化反应，而无需监测反应环境的pH值。式(I)化合物是MRI技术诊断对比剂制备中有用的中间体。
• Process for the Preparation of Gadobenate Dimeglumine Complex in a Solid Form
  申请人：Anelli Pier Lucio

  公开号：US20120232151A1

  公开（公告）日：2012-09-13

  The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

  本发明揭示了一种制备固态盐酸加多宝酸二甲胺盐的方法。具体而言，该固态形式可通过在给定温度和浓度下喷雾干燥相应的液体悬浮液方便地获得。本发明对于工业规模特别有优势，因为固态形式可以通过使用水作为溶剂来获得，水是一种无毒的溶剂，易于处理，基本上不需要繁琐的健康或安全预防措施。
• Process for the preparation of gadobenate dimeglumine complex in a solid form
  申请人：Bracco Imaging S.p.A

  公开号：EP2327395A1

  公开（公告）日：2011-06-01

  The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

  本发明公开了一种固态钆喷酸二葡胺复合物的制备方法。特别是，所述固体形式可通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地获得。水是一种无毒溶剂，易于处理，基本上不需要采取麻烦的健康或安全预防措施。
• Process for the purification of polyaminocarboxylates
  申请人：Biophore India Pharmaceuticals Pvt. Ltd.

  公开号：US10106489B2

  公开（公告）日：2018-10-23

  The present invention relates to an improved process for the purification of polyaminocarboxylates such as DOTA, DTPA, DO3A-butrol, BOPTA.

  本发明涉及一种用于提纯 DOTA、DTPA、DO3A-丁醇、BOPTA 等聚氨基羧酸盐的改进工艺。