7,8-Dimethoxy-1,2,3,4-tetrahydro-3-benzazepin-5-one | 1416064-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7,8-Dimethoxy-1,2,3,4-tetrahydro-3-benzazepin-5-one
• 英文别名: 7,8-dimethoxy-1,2,3,4-tetrahydro-3-benzazepin-5-one
• CAS: 1416064-72-6
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: JGYSTZXHZNPXMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7,8-Dimethoxy-1,2,3,4-tetrahydro-3-benzazepin-5-one 在 溶剂黄146 、 锌 作用下， 反应 1.0h， 以47%的产率得到1-甲基-6,7-二甲氧基-3,4-二氢异喹啉
  参考文献：
  名称：

  锌-乙酸促进α-氨基酮的还原碳-氮键断裂反应

  摘要：

  Scope and limitation of the reductive cleavage reaction of a-aminoketone systems with zinc-acetic acid are described. The carbon-nitrogen bond cleavage reaction was applicable to a wide range of alpha-aminoalkyl aryl ketones possessing various substituents on the aromatic ring. In contrast, a-aminoalkyl alkyl ketones with protons at the alpha'-position or alpha-aminoesters were sluggish to the carbon-nitrogen cleavage reaction.

  DOI：

  10.3987/com-13-s(s)64

文献信息

• Formal Synthesis of Cephalotaxine
  作者：Zhi-Wei Zhang、Xiao-Fang Zhang、Juan Feng、Yi-Hua Yang、Cui-Cui Wang、Jia-Cai Feng、Shouxin Liu

  DOI：10.1021/jo302608a

  日期：2013.1.18

  A formal synthesis of cephalotaxine, the parent member of the Cephalotaxus alkaloids, was achieved. It features a practical four-step assembly of the benzazepine-bearing pentacyclic ring system through two alkylation reactions, acidic hydrolysis, and aldolization.

  三尖杉碱的正式合成中，父构件三尖杉生物碱，达到了。它的特点是通过两个烷基化反应，酸性水解和醛醇缩合反应，对带有苯并ze庚因的五环系统进行实际的四步组装。
• Zinc-Acetic Acid Promoted Reductive Carbon-Nitrogen Bond Cleavage Reaction of α-Aminoketones
  作者：Hideaki Fujii、Kyoko Ishikawa、Miyuki Tomatsu、Hiroshi Nagase

  DOI：10.3987/com-13-s(s)64

  日期：——

  Scope and limitation of the reductive cleavage reaction of a-aminoketone systems with zinc-acetic acid are described. The carbon-nitrogen bond cleavage reaction was applicable to a wide range of alpha-aminoalkyl aryl ketones possessing various substituents on the aromatic ring. In contrast, a-aminoalkyl alkyl ketones with protons at the alpha'-position or alpha-aminoesters were sluggish to the carbon-nitrogen cleavage reaction.