pyrrole-2-propanamide | 55490-38-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: pyrrole-2-propanamide
• 英文别名: 3-(2-Pyrrol)-propionamid；3-pyrrol-2-yl-propionamide；1H-Pyrrole-2-propanamide；3-(1H-pyrrol-2-yl)propanamide
• CAS: 55490-38-5
• 化学式: C₇H₁₀N₂O
• mdl: MFCD19205942
• 分子量: 138.169
• InChiKey: YFCGRNLETBTFLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(2-吡咯基)丙酸甲酯 在 氰化钠 、 氨 作用下， 以 甲醇 为溶剂， 反应 96.0h， 以70%的产率得到pyrrole-2-propanamide
  参考文献：
  名称：

  Synthesis of cystamidin a (pyrrole-3-propanamide), a reported calpain inhibitor

  摘要：

  The reported calpain inhibitor cystamidin A (1a, pyrrole-3-propanamide) and a regioisomer, pyrrole-2-propanamide (1b) have been synthesized from the corresponding pyrrolecarboxaldehydes. The previously assigned structure of cystamidin A is confirmed. However, neither synthetic cystamidin A nor regioisomer Ib inhibits recombinant human calpain I. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00269-7

文献信息

• Pyrrole propionic acid amide, its production and use as calpain inhibitor
  申请人：THE KITASATO INSTITUTE

  公开号：EP0569122A1

  公开（公告）日：1993-11-10

  A compound of formula: or a pharmaceutically or veterinarilly acceptable salt thereof, is useful as a calpain inhibitor.

  式的化合物： 或其药学上或兽医学上可接受的盐，可用作钙蛋白酶抑制剂。
• [EN] AMINOALKYLIMIDAZOLE DERIVATIVES AND THEIR USE IN MEDICINE<br/>[FR] DERIVES D'AMINOALKYLIMIDAZOLE ET LEUR UTILISATION DANS LE DOMAINE MEDICAL
  申请人：MOLECULAR SKINCARE LTD

  公开号：WO2003045381A1

  公开（公告）日：2003-06-05

  The present invention provides compounds of formula (I) wherein R1 is selected from phenyl, quinoline, isoquinoline and anthracene whereby each of these substituents may be optionally substituted by a group selected from halogen, C¿1-4? alkoxy, C1-4 alkyl, C1-4 dialkylamino and cyano; R?2¿ is selected from hydrogen and phenyl optionally substituted by a group selected from halogen, C¿1-4? alkoxy, C1-4 alkyl, C1-4 dialkylamino and cyano; R?3¿ is selected from halogen, C¿1-12? hydrocarbyl, phenyl optionally substituted by a group selected from halogen, C1-4 alkoxy, C1-4 alkyl, C1-4 dialkylamino and cyano, and N-acyl piperazinyl; and X is selected from CO and SO2, with the proviso that when X is CO and R?1 and R3¿ are both optionally substituted phenyl, R2 is not hydrogen or when X is CO and R?2 and R3¿ are both optionally substituted phenyl, R1 is not hydrogen; and pharmaceutically acceptable derivatives and solvates thereof, pharmaceutical formulations containing them and their use in therapy particularly as CYP24 inhibitors.
• Synthesis of cystamidin a (pyrrole-3-propanamide), a reported calpain inhibitor
  作者：Ron Bihovsky、Israil Pendrak

  DOI：10.1016/s0960-894x(96)00269-7

  日期：1996.7

  The reported calpain inhibitor cystamidin A (1a, pyrrole-3-propanamide) and a regioisomer, pyrrole-2-propanamide (1b) have been synthesized from the corresponding pyrrolecarboxaldehydes. The previously assigned structure of cystamidin A is confirmed. However, neither synthetic cystamidin A nor regioisomer Ib inhibits recombinant human calpain I. Copyright (C) 1996 Elsevier Science Ltd