2-ethoxy-1-(2-deoxy-β-D-threofuranosyl)thymine | 131933-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-ethoxy-1-(2-deoxy-β-D-threofuranosyl)thymine
• 英文别名: 2-Ethoxy-1-((2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-4(1H)-one；2-ethoxy-1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-4-one
• CAS: 131933-45-4
• 化学式: C₁₂H₁₈N₂O₅
• 分子量: 270.285
• InChiKey: ALVZYWVHJVQICM-OPRDCNLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  91.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-ethoxy-1-(2-deoxy-5-O-trityl-β-D-threofuranosyl)thymine 以61%的产率得到
  参考文献：
  名称：

  COSFORD, NICHOLAS D. P.;SCHINAZI, RAYMOND F., J. ORG. CHEM., 56,(1991) N, C. 2161-2165

  摘要：

  DOI：

文献信息

• Selenium nucleophiles for the preparation of antiviral nucleosides
  作者：Nicholas D. P. Cosford、Raymond F. Schinazi

  DOI：10.1021/jo00006a037

  日期：1991.3

  The reactivity of nucleophilic selenium species toward nucleoside derivatives has been examined. A number of new 2'-deoxyribose nucleosides have been synthesized using this methodology. The cis elimination of the selenoxide obtained from the oxidation of the corresponding phenylselenide has been shown to be an efficient method for the preparation of the 2',3'-unsaturated antiviral nucleoside 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine (DAT).
• COSFORD, NICHOLAS D. P.;SCHINAZI, RAYMOND F., J. ORG. CHEM., 56,(1991) N, C. 2161-2165
  作者：COSFORD, NICHOLAS D. P.、SCHINAZI, RAYMOND F.

  DOI：——

  日期：——