2-bromo-N-[3-(4-methylpiperazine-1-carbonyl)phenyl]propanamide | 1001463-43-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-N-[3-(4-methylpiperazine-1-carbonyl)phenyl]propanamide
• CAS: 1001463-43-9
• 化学式: C₁₅H₂₀BrN₃O₂
• 分子量: 354.247
• InChiKey: DWQHQABSDYKNIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  {3-[(4-甲基哌嗪-1-基)羰基]苯基}胺 、 2-溴丙酰溴 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-bromo-N-[3-(4-methylpiperazine-1-carbonyl)phenyl]propanamide
  参考文献：
  名称：

  3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents

  摘要：

  We report the synthesis, anti proliferative activity, and SAR of novel 3-(2'-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5 mu M) against five solid tumor cell lines. The mechanism of action of the most potent benzamide 101 does not involve targeting on tubulin but it causes cell cycle S-phase arrest. This active S-phase arrest agent merits further investigation. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.016

文献信息

• 3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents
  作者：Laixing Hu、Zhuo-rong Li、Jian-Nong Li、Jinrong Qu、Jian-Dong Jiang、David W. Boykin

  DOI：10.1016/j.bmcl.2007.10.016

  日期：2007.12

  We report the synthesis, anti proliferative activity, and SAR of novel 3-(2'-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent cytotoxicities against Molt-3 leukemia cells. Several compounds exihibited cytotoxicities (under 6.5 mu M) against five solid tumor cell lines. The mechanism of action of the most potent benzamide 101 does not involve targeting on tubulin but it causes cell cycle S-phase arrest. This active S-phase arrest agent merits further investigation. (c) 2007 Elsevier Ltd. All rights reserved.