Z-Ser-Gly-OEt | 2766-22-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Ser-Gly-OEt
• 英文别名: ethyl 2-[[3-hydroxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]acetate
• CAS: 2766-22-5
• 化学式: C₁₅H₂₀N₂O₆
• mdl: MFCD00196989
• 分子量: 324.334
• InChiKey: ZOONJGSLKPDXCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Z-Ser-Gly-OEt 在 乙醇 、 肼 作用下， 生成 N-(N-benzyloxycarbonyl-DL-seryl)-glycine hydrazide
  参考文献：
  名称：

  Peptide Derivatives Containing Two Trifunctional Amino Acids

  摘要：

  DOI：

  10.1021/ja01649a019
• 作为产物：
  描述：

  ZSer, triethylammonium salt 以 四氢呋喃 为溶剂， 反应 17.0h， 生成 Z-Ser-Gly-OEt
  参考文献：
  名称：

  Peptide synthesis with benzo- and naphthosultones

  摘要：

  DOI：

  10.1021/jo00196a006

文献信息

• Epitaxial growth of ZnO films on Si(111)
  作者：Ashutosh Tiwari、M. Park、C. Jin、H. Wang、D. Kumar、J. Narayan

  DOI：10.1557/jmr.2002.0361

  日期：2002.10

  In this paper, we report the growth of ZnO films on silicon substrates using a pulsed laser deposition technique. These films were deposited on Si(111) directly as well as by using thin buffer layers of AlN and GaN. All the films were found to have c-axis-preferred orientation aligned with normal to the substrate. Films with AlN and GaN buffer layers were epitaxial with preferred in-plane orientation, while those directly grown on Si(111) were found to have random in-plane orientation. A decrease in the frequency of the Raman mode and a red shift of the band-edge photoluminescence peak due to the presence of tensile strain in the film, was observed. Various possible sources for the observed biaxial strain are discussed.

  在本文中，我们报告了利用脉冲激光沉积技术在硅基底上生长氧化锌薄膜的情况。这些薄膜直接沉积在硅(111)上，也使用了氮化铝和氮化镓薄缓冲层。所有薄膜都具有与基底法线对齐的 c 轴优先取向。使用氮化铝和氮化镓缓冲层的薄膜具有优先面内取向的外延，而直接生长在硅(111)上的薄膜则具有随机面内取向。由于薄膜中存在拉伸应变，拉曼模式的频率降低，带边光致发光峰发生红移。讨论了观察到的双轴应变的各种可能来源。
• Modulation of the P2Y2 receptor pathway
  申请人：P2-Science APS

  公开号：EP2036567A2

  公开（公告）日：2009-03-18

  The present invention relates to the field of regulating the activity of the purinergic receptors for the modulation of the vascular tone, particularly for the purpose of treatment of haemodynamic conditions by overriding of vasoconstriction activity, such as increases in sympathic vasoconstriction. Modulators, such as UTP analogues as described herein are preferably specific for P2Y2. Compounds capable of stimulating the P2Y2 receptor are suitable for the treatment or prevention wherein inhibition of vasoconstriction activity is desirable such as hypertension and hypertension relates disorders or diseases, whereas compound capable of counteracting the activity of the P2Y2 receptor are suitable for the treatment of or prevention wherein inhibition of vasodilatation is desirable.

  本发明涉及调节嘌呤能受体活性以调节血管张力的领域，特别是通过抑制血管收缩活性（如交感血管收缩增加）来治疗血流动力学疾病。调节剂，如本文所述的UTP 类似物，最好对 P2Y2 具有特异性。能够刺激 P2Y2 受体的化合物适用于治疗或预防需要抑制血管收缩活性的疾病，如高血压和高血压相关失调或疾病，而能够抵消 P2Y2 受体活性的化合物适用于治疗或预防需要抑制血管舒张的疾病。
• Compounds that bind P2Y2 or P2Y1 receptors
  申请人：——

  公开号：US20040116339A1

  公开（公告）日：2004-06-17

  The invention provides peptides and compounds that can bind to P2Y 2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.

  本发明提供了能与 P2Y 2 受体，可用于调节粘膜表面的粘液分泌。
• Riley et al., Journal of the Chemical Society, 1957, p. 1373,1375
  作者：Riley et al.

  DOI：——

  日期：——
• Martinez,J.; Winternitz,F., Bulletin de la Societe Chimique de France, 1972, p. 4707 - 4709
  作者：Martinez,J.、Winternitz,F.

  DOI：——

  日期：——