1-methoxy-4-[3-(4-methoxyphenyltelluryl)propyltelluryl]benzene | 403491-34-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-methoxy-4-[3-(4-methoxyphenyltelluryl)propyltelluryl]benzene
• 英文别名: 1-Methoxy-4-[3-(4-methoxyphenyl)tellanylpropyltellanyl]benzene；1-methoxy-4-[3-(4-methoxyphenyl)tellanylpropyltellanyl]benzene
• CAS: 403491-34-9
• 化学式: C₁₇H₂₀O₂Te₂
• 分子量: 511.545
• InChiKey: YKXAWKYBTFCGSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  bis(4-methoxyphenyl)ditelluride 在 sodium tetrahydroborate 作用下， 生成 1-methoxy-4-[3-(4-methoxyphenyltelluryl)propyltelluryl]benzene
  参考文献：
  名称：

  摘要：

  Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 similar to 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer's and related diseases.

  DOI：

  10.1039/b107972g

文献信息

• Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential
  作者：Gregory I. Giles、Fiona H. Fry、Karen M. Tasker、Andrea L. Holme、Chris Peers、Kim N. Green、Lars-Oliver Klotz、Helmut Sies、Claus Jacob

  DOI：10.1039/b308117f

  日期：——

  Oxidative stress is implicated, either directly or indirectly, in the pathology of a range of human diseases. As a consequence, the development of efficient antioxidants for medical use has become increasingly important. We have synthesised a range of structurally related organo-sulfur, -selenium and -tellurium agents and demonstrated that a combination of electrochemical methodology, in vitro assays

  氧化应激直接或间接地牵涉到一系列人类疾病的病理学中。结果，开发用于医学的有效抗氧化剂变得越来越重要。我们已经合成了一系列结构相关的有机硫，-硒和-碲试剂，并证明了电化学方法，体外测定法和细胞培养试验的组合可用于合理化这些催化剂的抗氧化活性。基于其极低的阳极氧化电位（Epa）和对代表性氧化应激因子叔丁基氢过氧化物和过氧亚硝酸盐的高活性，预计4,4'-二羟基二苯基碲化物是有效的抗氧化剂。该化合物具有较高的活性，IC50值非常低，仅为20 nM，
• ——
  作者：Gregory I. Giles、Karen M. Tasker、Russell J. K. Johnson、Claus Jacob、Chris Peers、Kim N. Green

  DOI：10.1039/b107972g

  日期：2001.11.22

  Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 similar to 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer's and related diseases.