3-amino-2-<(2-amino-2-oxoethyl)amino>pyridine | 118699-05-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-2-<(2-amino-2-oxoethyl)amino>pyridine
• 英文别名: 2-[(3-amino-2-pyridinyl)amino]acetamide；2-[(3-aminopyridin-2-yl)amino]acetamide
• CAS: 118699-05-1
• 化学式: C₇H₁₀N₄O
• 分子量: 166.183
• InChiKey: UNXDGGNIROJCKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  94
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-amino-2-<(2-amino-2-oxoethyl)amino>pyridine 生成 N-[2-[(2-amino-2-oxoethyl)amino]-3-pyridinyl]-2-pyridinecarboxamide
  参考文献：
  名称：

  TOMCZUK, BRUCE E.;SUTHERIAND, DEBORAH S.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-<(3-nitro-2-pyridinyl)amino>acetamide 在 钯 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 生成 3-amino-2-<(2-amino-2-oxoethyl)amino>pyridine
  参考文献：
  名称：

  Fused imidazoheterocyclic compounds and pharmaceutical compositions

  摘要：

  咪唑杂环化合物的化学式为：##STR1## 其中A环是吡啶的四个位置中的任意一个；B是羰基、硫代甲基或羟甲基；Z是氢、卤素、较低烷基、羟基、较低烷氧基、二较低烷基氨基或硝基；Ar是苯基、吡啶基、噻吩基或呋喃基；W与B形成多种组合，包括酸、酯、醇、酰胺和酮。这些化合物在治疗活体动物身体的方法中具有中枢神经系统活性，可用作肌肉松弛剂、抗惊厥剂和抗焦虑剂。

  公开号：

  US04772600A1

文献信息

• [EN] DIAZACARBAZOLES AND METHODS OF USE<br/>[FR] DIAZACARBAZOLES ET PROCÉDÉS D'UTILISATION
  申请人：GENENTECH INC

  公开号：WO2009151589A1

  公开（公告）日：2009-12-17

  The invention relates to 1,5-diazacarbazole compounds of Formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) and (I-h) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chkl) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及式(I)、(I-a)、(I-b)、(I-c)、(I-d)、(I-e)、(I-f)、(I-g)和(I-h)的1,5-二氮杂咯化合物，其作为激酶抑制剂具有用途，更具体地作为检查点激酶1（chkl）抑制剂，因此作为癌症治疗剂具有用途。本发明还涉及包含这些化合物的组合物，更具体地是包含这些化合物的药物组合物以及使用这些化合物治疗各种癌症和高增殖性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体内、体外和原位诊断或治疗，或相关的病理条件的方法。
• Method of treating animals using fused imidazoheterocyclic compounds
  申请人：A. H. Robins Company, Incorporated

  公开号：US04914109A1

  公开（公告）日：1990-04-03

  Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity in a method for treating a living animal body as muscle relaxants, anticonvulsants and antianxiety agents.

  具有以下式子的咪唑杂环化合物：##STR1## 其中A环是吡啶，可以在其四个位置中的任何一个；B是羰基，硫代甲基或羟甲基；Z是氢，卤素，低碳基，羟基，低碳氧基，二低碳基氨基或硝基；Ar是苯基，吡啶基，噻吩基或呋喃基；W与B形成各种各样的基团组合，包括酸，酯，醇，酰胺和酮。这些化合物在治疗活体动物身体的肌肉松弛剂，抗癫痫剂和抗焦虑剂的方法中具有中枢神经系统活性。
• Pharmaceutical method using fused imidazoheterocyclic compounds
  申请人：A. H. Robins Company, Incorporated

  公开号：US04948800A1

  公开（公告）日：1990-08-14

  Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity in a method for treating a living animal body as muscle relaxants, anticonvulsants and antianxiety agents.

  具有以下式子的咪唑杂环化合物：##STR1## 其中A环是吡啶，可以位于其四个位置之一；B是羰基，硫代甲基或羟甲基；Z是氢，卤素，低烷基，羟基，低烷氧基，二低烷基氨基或硝基；Ar是苯基，吡啶基，噻吩基或呋喃基；W与B形成广泛的基团组合，包括酸，酯，醇，酰胺和酮。这些化合物在治疗活体动物身体作为肌肉松弛剂，抗癫痫剂和抗焦虑剂的方法中具有中枢神经系统活性。
• Fused imidazopyridine compounds
  申请人：A. H. Robins Company, Incorporated

  公开号：US04824951A1

  公开（公告）日：1989-04-25

  Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar is phenyl, pyrido, thienyl or furanyl; and W forms a wide combination of groups with B, including acids, esters, alcohols, amides and ketones. The compounds have CNS activity in a method for treating a living animal body as muscle relaxants, anticonvulsants and antianxiety agents.

  具有以下式子的咪唑杂环化合物：##STR1## 其中A环是吡啶，可以在其四个位置中的任意一个；B是羰基，硫代甲基或羟甲基；Z是氢，卤素，较低的烷基，羟基，较低的烷氧基，二较低烷基氨基或硝基；Ar是苯基，吡啶基，噻吩基或呋喃基；W与B形成广泛的组合，包括酸，酯，醇，酰胺和酮。这些化合物在治疗活体动物体作为肌肉松弛剂，抗惊厥剂和抗焦虑剂时具有中枢神经系统活性。
• 2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as nonbenzodiazepine anticonvulsants and anxiolytics
  作者：Bruce E. Tomczuk、C. R. Taylor、L. Meredith Moses、Deborah B. Sutherland、Young S. Lo、David N. Johnson、William B. Kinnier、Brian F. Kilpatrick

  DOI：10.1021/jm00114a007

  日期：1991.10

  A series of 2-phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytics based on a molecular disconnection of a typical 1,4-benzodiazepine (BZD). A number of these compounds showed submicromolar potency in a [H-3]benzodiazepine binding assay in vitro and good potency in protecting rodents against pentylenetetrazole-induced seizures. Compound 84 appears to be a selective anticonvulsant (pentylenetetrazole) agent when tested against a profile of chemically and electrically induced seizures in mice. In addition, compound 148 appears to be a selective anxiolytic/hypnotic agent on the basis of biochemical and pharmacological characterization. It appears to be a full BZD agonist as assessed by GABA shift ratio and to be effective in punishment and nonpunishment animal models of anxiety. In addition, it shows a lower side-effect profile than diazepam as assessed by rotorod neurotoxicity and potentiation of ethanol-induced sleep time in mice. The chemistry and structure-activity relationships of this series is discussed.