6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridin-3-carboxylic acid | 1295522-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridin-3-carboxylic acid
• 英文别名: 6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridine-3-carboxylic acid；6-methoxy-2-(triazol-2-yl)pyridine-3-carboxylic acid
• CAS: 1295522-68-7
• 化学式: C₉H₈N₄O₃
• 分子量: 220.188
• InChiKey: AISJUXGEUDSGSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-methyl-2-{[(3R,6R)-6-methylpiperidin-3-yl]oxy}pyridin-4-carbonitrile 、 6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridin-3-carboxylic acid 在 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-{[(3R,6R)-1-{[6-methoxy-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl]carbonyl}-6-methylpiperidin-3-yl]oxy}-3-methylpyridin-4-carbonitrile
  参考文献：
  名称：

  [EN] 2-PYRIDYLOXY-3-SUBSTITUTED-4-NITRILE OREXIN RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTES DU RÉCEPTEUR DE LA 2-PYRIDYLOXY-3-SUBSTITUÉE-4-NITRILE ORÉXINE

  摘要：

  本发明涉及2-吡啶氧基-3-取代-4-腈化合物，其是促进睡眠荷尔蒙受体的拮抗剂。本发明还涉及使用本文所述的2-吡啶氧基-3-取代-4-腈化合物在治疗或预防神经系统和精神疾病中的用途，其中涉及促进睡眠荷尔蒙受体。本发明还涉及包含这些化合物的制药组合物。本发明还涉及使用这些制药组合物在预防或治疗涉及促进睡眠荷尔蒙受体的疾病中的用途。

  公开号：

  WO2014066196A1

文献信息

• [EN] FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES CONDENSÉS EN TANT QUE MODULATEURS DE RÉCEPTEUR D'OREXINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011050200A1

  公开（公告）日：2011-04-28

  Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo [3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

  描述了二取代的3,8-二氮杂双环[4.2.0]辛烷和3,6-二氮杂双环[3.2.0]庚烷化合物，这些化合物可用作促进睡眠素受体的调节剂。这些化合物可能在药物组合物和治疗由促进睡眠素活性介导的疾病状态、紊乱和症状的方法中有用，比如失眠。
• [EN] 2-HYDROXYMETHYL-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE SUBSTITUÉS PAR UN GROUPE 2-HYDROXYMÉTHYLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014176144A1

  公开（公告）日：2014-10-30

  The present invention is directed to 2-hydroxymethyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对促觉醒素受体拮抗剂的2-羟甲基化合物。本发明还涉及所述化合物在潜在治疗或预防促觉醒素受体参与的神经学和精神疾病和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗促觉醒素受体参与的这类疾病中的用途。
• [EN] THIOETHER-PIPERIDINYL OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS THIOÉTHER-PIPÉRIDINYLE SERVANT D'ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015095108A1

  公开（公告）日：2015-06-25

  The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thioether-piperidinyl compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及硫醚哌啶基化合物，其为俄雷欣受体拮抗剂。本发明还涉及所述硫醚哌啶基化合物在潜在治疗或预防神经学和精神疾病中的用途，其中俄雷欣受体参与其中。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗俄雷欣受体参与的疾病中的用途。
• FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS
  申请人：Branstetter Bryan James

  公开号：US20120202783A1

  公开（公告）日：2012-08-09

  Disubstituted 3,8-diaza-bicyclo[4.2.0]octane and 3,6-diazabicyclo[3.2.0]heptane compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

  本文描述了双取代的3,8-二氮杂-四环[4.2.0]辛烷和3,6-二氮杂-三环[3.2.0]庚烷化合物，可用作促进荷尔蒙受体的调节剂。这些化合物可用于制备药物组合物和治疗由荷尔蒙活性介导的疾病状态、紊乱和情况，如失眠。
• 2-PYRIDYLOXY-3-SUBSTITUTED-4-NITRILE OREXIN RECEPTOR ANTAGONISTS
  申请人：KUDUK Scott D.

  公开号：US20150291558A1

  公开（公告）日：2015-10-15

  The present invention is directed to 2-pyridyloxy-3-substituted-4-nitrile compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the 2-pyridyloxy-3-substituted-4-nitrile compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及2-吡啶氧基-3-取代-4-腈化合物，其为促进睡眠激素受体的拮抗剂。本发明还涉及使用本文所述的2-吡啶氧基-3-取代-4-腈化合物在治疗或预防神经和精神障碍和疾病中的应用，其中促进睡眠激素受体参与其中。本发明还涉及包含这些化合物的药物组合物。本发明还涉及使用这些药物组合物在预防或治疗促进睡眠激素受体参与的疾病中的应用。