2-Methoxy-2'-methyldiphenylether | 140380-82-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methoxy-2'-methyldiphenylether
• 英文别名: 1-methoxy-2-m-tolyloxy-benzene；1-Methoxy-2-m-tolyloxy-benzol；Benzene, 1-methoxy-2-(3-methylphenoxy)-；1-methoxy-2-(3-methylphenoxy)benzene
• CAS: 140380-82-1
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: WPWCCTZDSJTZRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methoxy-2'-methyldiphenylether 在 氢碘酸 、 溶剂黄146 作用下， 生成 2-m-Tolyloxy-phenol
  参考文献：
  名称：

  Methoxy (and Hydroxy) Phenoxybenzoic Acids

  摘要：

  DOI：

  10.1021/jo50002a021
• 作为产物：
  描述：

  3-溴甲基苯 、 木榴油 在 copper(l) iodide 、 potassium carbonate 作用下， 反应 4.0h， 以73%的产率得到2-Methoxy-2'-methyldiphenylether
  参考文献：
  名称：

  Smith, Keith; Jones, Dennis, Journal of the Chemical Society. Perkin transactions I, 1992, # 4, p. 407 - 408

  摘要：

  DOI：

文献信息

• N-sulphonylated amino acid derivatives, method for the production and use thereof
  申请人：Sturzebecher Jorg

  公开号：US20070055065A1

  公开（公告）日：2007-03-08

  The present invention relates to N-sulfonylated amino acid derivatives, where an aryl radical is linked via the sulfonyl group N-terminally to the amino acid and a radical which comprises at least one imino group and at least one further basic group which represents an optionally modified amino, amidino or guanidino group is linked C-terminally via the carbonyl group. The invention likewise relates to processes for preparing these compounds and to their use, in particular as inhibitors of matriptase.

  本发明涉及N-磺酰化氨基酸衍生物，其中芳基基团通过磺酰基N-末端与氨基酸连接，而包含至少一个亚胺基团和至少一个其他碱性基团的基团则通过羰基基团C-末端连接。本发明还涉及制备这些化合物的方法以及它们的用途，特别是作为matriptase的抑制剂。
• 17BetaHSD Type 5 Inhibitor
  申请人：Niimi Tatsuya

  公开号：US20110071146A1

  公开（公告）日：2011-03-24

  To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

  提供一种新颖和优秀的方法，用于基于对17βHSD类型5的选择性抑制活性，治疗和/或预防前列腺癌、良性前列腺增生、痤疮、脂溢性皮炎、多毛症、秃发、脱发、早熟、肾上腺增生、多囊卵巢综合症、乳腺癌、肺癌、子宫内膜异位症、平滑肌瘤等疾病。发现一种N-磺酰基吲哚衍生物，其中吲哚环在其碳原子上被羧基取代，或者被羧基取代的低烷基或低烯基取代，具有强大的选择性抑制17βHSD类型5的活性，可能成为治疗和/或预防良性前列腺增生、前列腺癌等疾病的治疗剂和/或预防剂，而不伴随着由于睾酮降低而产生的不良药物反应，因此本发明得以完成。
• 17BetaHSD TYPE 5 INHIBITOR
  申请人：Niimi Tatsuya

  公开号：US20090181960A1

  公开（公告）日：2009-07-16

  To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

  提供一种新颖优良的方法，用于基于对17βHSD type 5的选择性抑制活性，治疗和/或预防前列腺癌、良性前列腺增生、痤疮、皮脂溢出、多毛症、脱发、早熟、肾上腺增生、多囊卵巢综合症、乳腺癌、肺癌、子宫内膜异位症、平滑肌瘤等疾病。发现一种N-磺酰基吲哚衍生物，其中吲哚环在其碳原子上被羧基、羧基取代的低碳基或羧基取代的低烯基取代，具有强大的选择性抑制17βHSD type 5的活性，可以成为治疗剂和/或预防剂，用于治疗良性前列腺增生、前列腺癌等疾病，不会伴随着由于睾酮减少而引起的不良药物反应，因此本发明已经完成。
• N-SULPHONYLATED AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
  申请人：Stürzebecher Jörg

  公开号：US20110002992A1

  公开（公告）日：2011-01-06

  The present invention relates to N-sulfonylated amino acid derivatives, where an aryl radical is linked via the sulfonyl group N-terminally to the amino acid and a radical which comprises at least one imino group and at least one further basic group which represents an optionally modified amino, amidino or guanidino group is linked C-terminally via the carbonyl group. The invention likewise relates to processes for preparing these compounds and to their use, in particular as inhibitors of matriptase.

  本发明涉及N-磺酰基氨基酸衍生物，其中芳基基团通过磺酰基N末端与氨基酸连接，而包含至少一个亚胺基团和至少一个进一步的碱性基团的基团，该基团表示为可选修饰的氨基，酰胺基或鸟氨酸基团，通过羰基基团C末端连接。本发明还涉及制备这些化合物的方法及其用途，特别是作为matriptase的抑制剂。
• Fungicides
  申请人：ZENECA LIMITED

  公开号：EP0307103A2

  公开（公告）日：1989-03-15

  Fungicidal compounds of the formula (I) : and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is 0, S(O)n, NR4, CR'R2, CHRS, CO, CR'(OR2), C=CR1R2, CHR1CHR2, CR' =CR2, CHR1CR2=CH, C-C, OCHR', CHR'O, OCHR'O, S(O)nCHR', S(O)nCHR'O, CHR'S(0)n, CHR1OSO2, NR4CHR1, CHR1NR4, C02, 02C, S020, OSO2, CO.CO, COCHR', COCHR'O, CHR'CO, CHOH.CHR1, CHR'.CHOH, CONR4, OCONR4, NR4CO, CSNR4, OCS.NR4, SCO.NR4, NR4CO2, NR4CS, NR4CSO, NR4COS, NR4CONR4, S(O)nNR4, NR4S(O)n, CS2, S2C, CO.S, SCO, N=N, N=CR1, CR1=N, CHR1CHR2CH(OH), CHR'OCO, CHR'SCO, CHR1NR4CO, CHR'NR4COR4, CHR'CHR2CO, O.N=CR', CHR1O.N=CR2, CO.OCR'R2, CHR'CHR2CHR3, OCHR1CHR2, (CH2)mO, CHR1OCHR2, CHR'CHR20, OCHR'CHR20, S(O)-nCHR1CHR1, CHR1S(O)nCHR2, CHR'CHR2S(O)n. CR1=NNR4. NR4N=CR1, CHR1CONR2, CHR1OCO.NR2, CH=CHCH2O, COCHR1CHR2O or (R5)2P+CHR2Q-; A, B and E, which may be the same or different, are H, hydroxy, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, phenoxy, nitro or cyano; R', R2 and R3, which may be the same or different, are H, C1-4 alkyl or phenyl; R4 is H, C1-4 alkyl or COR'; R5 is optionally substituted phenyl; Q- is a halide anion; n is 0, 1 or 2 and m is a 3, 4 or 5; except that when Z is unsubstituted phenyl and X and K are oxygen, A, B and E are not all hydrogen.

  式 (I) ： 及其立体异构体，其中 K 是氧或硫；Z 是任选取代的芳基或任选取代的杂芳基；X 是 0、S(O)n、NR4、CR'R2、CHRS、CO、CR'(OR2)、C=CR1R2、CHR1CHR2、CR' =CR2、CHR1CR2=CH、C-C、OCHR'、CHR'O、OCHR'O、S(O)nCHR'、S(O)nCHR'O、CHR'S(0)n、CHR1OSO2、NR4CHR1、CHR1NR4、C02、02C、S020、OSO2、CO.CO、COCHR'、COCHR'O、CHR'CO、CHOH.CHR1、CHR'.CHOH、 CONR4、OCONR4、NR4CO、CSNR4、OCS.NR4、SCO.NR4、NR4CO2、NR4CS、NR4CSO、NR4COS、NR4CONR4、S(O)nNR4、NR4S(O)n、CS2、S2C、CO.S、SCO、N=N、N=CR1、CR1=N、CHR1CHR2CH(OH)、CHR'OCO、CHR'SCO、CHR1NR4CO、CHR'NR4COR4、CHR'CHR2CO、O。N=CR'，CHR1O.N=CR2，CO.OCR'R2，CHR'CHR2CHR3，OCHR1CHR2，(CH2)mO，CHR1OCHR2，CHR'CHR20，OCHR'CHR20，S(O)-nCHR1CHR1，CHR1S(O)nCHR2，CHR'CHR2S(O)n。CR1=NNR4。NR4N=CR1，CHR1CONR2，CHR1OCO。NR2、CH=CHCH2O、COCHR1CHR2O 或 (R5)2P+CHR2Q-；A、B 和 E 可以相同或不同，它们是 H、羟基、卤代、C1-4 烷基、C1-4 烷氧基、C1-4 卤代烷基、C1-4 卤代烷氧基、C1-4 烷基羰基、C1-4 烷氧基羰基、苯氧基、硝基或氰基；R'、R2 和 R3（可以相同或不同）是 H、C1-4 烷基或苯基；R4 是 H、C1-4 烷基或 COR'；R5 是任选取代的苯基；Q- 是卤化阴离子；n 是 0、1 或 2，m 是 3、4 或 5；但当 Z 是未取代的苯基且 X 和 K 是氧时，A、B 和 E 并非都是氢。