(9)-Paradol | 53172-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (9)-Paradol
• 英文别名: <9>-Paradol；1-(4-hydroxy-3-methoxy-phenyl)-tridecan-3-one；1-(4-Hydroxy-3-methoxy-phenyl)-tridecan-3-on；1-(4-Hydroxy-3-methoxyphenyl)tridecan-3-one；1-(4-hydroxy-3-methoxyphenyl)tridecan-3-one
• CAS: 53172-05-7
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.472
• InChiKey: RYIKCWWQEACMPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-十二烷酮 在 platinum(IV) oxide 四氢吡咯 、 氢气 、 溶剂黄146 作用下， 生成 (9)-Paradol
  参考文献：
  名称：

  辛辣的化合物。第一部分。改进的对位异构体（烷基4-羟基-3-甲氧基苯乙基酮）的合成及其辛辣度评估

  摘要：

  同源系列的11个对位的多巴酚，其中一个[6]对位的多酚（正庚基4-羟基-3-甲氧基苯乙基酮）天然存在于砂仁砂仁（Zingiberaceae）的种子中（也称为天堂谷物） ，几内亚胡椒或Melegueta胡椒）已通过一种改良方法合成。该系列介绍了包括g​​lc行为在内的物理特性和刺激性评估实验。

  DOI：

  10.1039/p19720003001

文献信息

• Daily Mortality in the Philadelphia Metropolitan Area and Size-Classified Particulate Matter
  作者：Frederick W. Lipfert、Samuel C. Morris、Ronald E. Wyzga

  DOI：10.1080/10473289.2000.10464185

  日期：2000.8

  Time-series of daily mortality data from May 1992 to September 1995 for various portions of the seven-county Philadelphia, PA, metropolitan area were analyzed in relation to weather and a variety of ambient air quality parameters. The air quality data included measurements of size-classified PM, SO42-, and H+ that had been collected by the Harvard School of Public Health, as well as routine air pollution monitoring data. Because the various pollutants df interest were measured at different locations within the metropolitan area, it was necessary to test for spatial sensitivity by comparing results for different combinations of locations,Estimates are presented for single pollutants and for multiple-pollutant models, including gaseous pollutants and mutually exclusive components of PM (PM2.5 and coarse particles, SO42- and non-SO42- portions of total suspended particulate [TSP] and PM10), measured on the day of death and the previous day.We concluded that associations between air quality and mortality were not limited to data collected in the same part of the metropolitan area; that is, mortality for one part may be associated with air quality data from another, not necessarily neighboring, part. Significant associations were found for a wide variety of gaseous and particulate pollutants, especially for peak O-3. Using joint regressions on peak O-3 with various other pollutants, we found that the combined responses were insensitive to the specific other pollutant selected. We saw no systematic differences according to particle size or chemistry. In general, the associations between daily mortality and air pollution depended on the pollutant or the PM metric, the type of collection filter used, and the location of sampling. Although peak O-3 seemed to exhibit the most consistent mortality responses, this finding should be confirmed by analyzing separate seasons and other time periods.
• Pungent compounds. Part I. An improved synthesis of the paradols (alkyl 4-hydroxy-3-methoxyphenethyl ketones) and an assessment of their pungency
  作者：H. D. Locksley、D. K. Rainey、T. A. Rohan

  DOI：10.1039/p19720003001

  日期：——

  of the homologous series of paradols, of which one, [6]paradol (n-heptyl 4-hydroxy-3-methoxyphenethyl ketone), occurs naturally in the seeds of Amomum melegueta Roscoe (Zingiberaceae)(otherwise known as Grains of Paradise, Guinea pepper, or Melegueta pepper), have been synthesised by an improved method. Physical characteristics, including g.l.c. behaviour, and pungency evaluation experiments are described

  同源系列的11个对位的多巴酚，其中一个[6]对位的多酚（正庚基4-羟基-3-甲氧基苯乙基酮）天然存在于砂仁砂仁（Zingiberaceae）的种子中（也称为天堂谷物） ，几内亚胡椒或Melegueta胡椒）已通过一种改良方法合成。该系列介绍了包括g​​lc行为在内的物理特性和刺激性评估实验。