N-Propyl-2,6-dimethoxyaniline | 253681-17-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Propyl-2,6-dimethoxyaniline
• 英文别名: 2,6-dimethoxy-N-propylaniline
• CAS: 253681-17-3
• 化学式: C₁₁H₁₇NO₂
• mdl: MFCD09953113
• 分子量: 195.261
• InChiKey: PYOSNJAPXRQHBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Propyl-2,6-dimethoxyaniline 在 三氯化铝 、 PPA 作用下， 以 甲苯 为溶剂， 反应 10.0h， 生成 (2,4-Dihydroxy-3-propylamino-phenyl)-phenyl-methanone
  参考文献：
  名称：

  Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

  摘要：

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00504-1
• 作为产物：
  描述：

  1,3-二甲氧基-2-硝基苯 在 铁粉 、 溶剂黄146 作用下， 反应 10.0h， 生成 N-Propyl-2,6-dimethoxyaniline
  参考文献：
  名称：

  Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

  摘要：

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00504-1

文献信息

• Aminothiazole derivatives, process for preparing them and pharmaceutical compositions containing them
  申请人：——

  公开号：US20020137740A1

  公开（公告）日：2002-09-26

  The subject of the invention is the compounds of formula: 1 in which R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in Claim 1. The compounds have a high affinity for the CRF receptors.

  本发明的主题是公式1中的化合物：其中R1，R2，R3，R4，R5和R6如权利要求书1所定义的那样。这些化合物具有高亲和力CRF受体。
• DERIVES D'AMINOTHIAZOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：SANOFI-SYNTHELABO

  公开号：EP0934290B1

  公开（公告）日：2002-04-17
• US6344470B1
  申请人：——

  公开号：US6344470B1

  公开（公告）日：2002-02-05
• Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro
  作者：Ronan Larget、Brian Lockhart、Bruno Pfeiffer、Anne Neudorffer、Maurice-Bernard Fleury、Martine Largeron

  DOI：10.1016/s0960-894x(99)00504-1

  日期：1999.10

  A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol. (C) 1999 Elsevier Science Ltd. All rights reserved.