七氯 | 76-44-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 七氯
• 中文别名: 1,4,5,6,7,8,8-七氯-4,7-亚甲基桥-3Α,4,7,7Α-四氢茚;；1,4,5,6,7,8,8-七氯-4,7-桥甲撑-3Α,4,7,7Α-四氢茚；环氧七氯；七氯化茚；七氯化茚,1,4,5,6,7,8,8-七氯-3a,4,7,7a-四氢-4,7-亚甲基-1-茚；1,4,5,6,7,8,8-七氯-4,7-亚甲基桥-3Α,4,7,7Α-四氢茚；1,4,5,6,7,8,8-七氯-3A,4,7,7A-四氢-4,7-亚甲基-1-茚
• 英文名称: heptachlor
• 英文别名: 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethano-indene；1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.02,6]deca-3,8-diene
• CAS: 76-44-8
• 化学式: C₁₀H₅Cl₇
• 分子量: 373.321
• InChiKey: FRCCEHPWNOQAEU-UHFFFAOYSA-N

物化性质

• 物理描述：
  Heptachlor is a white to light tan waxy looking solid. Noncombustible. Insoluble in water. Can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used as an insecticide.
• 颜色/状态：
  White to light tan waxy solid
• 气味：
  Camphor-like odor
• 沸点：
  310.0 °C
• 熔点：
  95.5 °C
• 溶解度：
  In water, 0.18 mg/l @ 25 °C
• 密度：
  1.57 @ 9 °C
• 蒸汽压力：
  4.0X10-4 mm Hg @ 25 °C
• 亨利常数：
  2.94e-04 atm-m3/mole
• 稳定性/保质期：
  STABLE TO DAYLIGHT, AIR, MOISTURE, AND MODERATE HEAT (UP TO 160 °C).
• 分解：
  160 °C
• 腐蚀性：
  Corrosive to metals.
• 气味阈值：
  0.02 PPM
• 保留指数：
  1861;1861;1863;1863;1865;1866;1867;1867;1870;1889;1910;1890;1891;1885;1893.3;1860.7;1905.3;1889.7;1889.6;1883;1841;1864;1875.4;1870;1873;1873;1890;1876.7;1930;1880;1875.9;1881.2;1873.3;1890.5

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

老鼠代谢静脉注射的（14）C-标记的七氯成为环氧（在组织、粪便和尿液中发现）以及4,5,6,7,8,8-六氯-1-外羟基-6,7-外环氧-1,2,3A,4,7,7A-六氢-1,4-内亚甲基茚...这种亲水性代谢物通过尿液排出。在兔子中，放射性标记主要在尿液中发现（20%环氧，80%亲水性代谢物）。从连续30天喂食每千克饮食10毫克七氯环氧的大鼠粪便中分离出另一种粪便代谢物（1-羟基-2,3-环氧氯二烯的一种脱氢衍生物）。

RATS METABOLIZE IV ADMINISTERED (14)C-LABELED HEPTACHLOR TO THE EPOXIDE (FOUND IN TISSUES, FECES & URINE) & TO 4,5,6,7,8,8-HEXACHLORO-1-EXO-HYDROXY-6,7-EXO-EPOXY-1,2,3A,4,7,7A-HEXAHYDRO- 1,4-ENDO-METHYLENEINDENE ... A HYDROPHILIC METABOLITE WHICH IS EXCRETED IN THE URINE. IN RABBITS, THE RADIOACTIVE LABEL WAS FOUND MAINLY IN THE URINE (20% EPOXIDE, 80% HYDROPHILIC METABOLITE). ANOTHER FECAL METABOLITE (A DEHYDROGENATED DERIVATIVE OF 1-HYDROXY-2,3-EPOXYCHLORDENE) WAS ISOLATED FROM RATS FED 10 MG/KG DIET HEPTACHLOR EPOXIDE FOR 30 DAYS.

来源:Hazardous Substances Data Bank (HSDB)

代谢

被家蝇代谢成七氯环氧酯。

... METABOLIZED BY HOUSEFLIES ... TO HEPTACHLOR EPOXIDE.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在一个代谢研究中，将光七氯，一种七氯的有毒光异构体，通过腹腔注射（0.93毫克/千克）到大鼠体内，并收集了4周的排泄物，用于通过气相色谱/质谱分析代谢物。在体外实验中，将含有(14)C-光七氯的大鼠肝脏匀浆孵化并提取。两种主要代谢物分子结构表明，它们是通过光七氯的2个不同C-Cl键羟基化产生的。其中一种代谢物与葡萄糖醛酸结合。体外实验表明这些化合物来源于肝脏。在其他组织检查中，放射性物质是可溶于有机溶剂的，包含光七氯及其非极性代谢物。

IN A METABOLIC STUDY, PHOTOHEPTACHLOR, A TOXIC PHOTOISOMER OF HEPTACHLOR, WAS INJECTED IP (0.93 MG/KG) INTO RATS & EXCRETA WAS COLLECTED FOR 4 WK FOR ANALYSIS OF METABOLITES USING GC/MASS SPECTROMETRY. IN AN IN VITRO STUDY, RAT LIVER HOMOGENATES WERE INCUBATED WITH (14)C-PHOTOHEPTACHLOR & EXTRACTED. MOLECULAR STRUCTURES OF 2 OF THE MAJOR METABOLITES INDICATED THAT THEY WERE PRODUCED BY HYDROXYLATION AT 2 DIFFERENT C-CL BONDS OF PHOTOHEPTACHLOR. ONE OF THE METABOLITES WAS CONJUGATED WITH GLUCURONIC ACID. THE IN VITRO TESTS SHOWED THE COMPOUNDS TO BE OF HEPATIC ORIGIN. IN OTHER TISSUE EXAM, RADIOACTIVITY WAS ORGANOSOLUBLE, CONTAINING PHOTOHEPTACHLOR & ITS NONPOLAR METABOLITES.

来源:Hazardous Substances Data Bank (HSDB)

代谢

大鼠肝脏微粒体制备来自成年雄性Sprague-Dawley大鼠，用于检查在无氧条件下化学物质的改变。大多数化学物质通过微粒体被无氧代谢为预期的还原代谢物。七氯通过脱氯化反应转化为氯丹。

RAT LIVER MICROSOMAL PREPN FROM ADULT MALE SPRAGUE-DAWLEY RATS WERE USED TO EXAM ALTERATION OF CHEMICALS IN ANAEROBIC CONDITIONS. MOST OF THE CHEMICALS WERE ANAEROBICALLY METABOLIZED TO THEIR EXPECTED REDUCTIVE METABOLITES BY MICROSOMES. HEPTACHLOR WAS CONVERTED TO CHLORDENE BY DECHLORINATION.

来源:Hazardous Substances Data Bank (HSDB)

代谢

庚氯（Heptachlor）可以通过皮肤、肺和胃肠吸收。它容易被肝脏微粒体代谢成庚氯环氧（heptachlor epoxide），这是其最持久和有毒的代谢物，主要储存在脂肪组织中。庚氯环氧通过尿液和粪便排出。

Heptachlor is readily absorbed by the skin, lungs and gastrointestinal tract. It is readily metabolized by liver microsomes into heptachlor epoxide, its most persistent and toxic metabolite, which is mainly stored in adipose tissue. Heptachlor epoxide is excreted in the urine and faeces. (L118)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

识别：七氯是一种在环境中持久存在并在食物链中积累的氯代二环戊二烯类杀虫剂。尽管自20世纪80年代以来，许多国家已经禁止或严格限制其使用，但它仍然在某些食品商品中被检测为污染物。在室温下，纯七氯呈现为白色或浅棕色的结晶固体，具有轻微的樟脑或雪松般的气味。技术产品是一种软蜡。技术产品通常含有约72%的七氯和约28%的相关化合物，如反式氯丹（20-22%）和反式九氯（4-8%）。人类暴露：在人类中，已经注意到胎盘转移七氯。现有的流行病学数据没有显示不良健康效应与暴露于七氯之间的明确关系。食用含有杀虫剂（如七氯）的食物会导致这些化合物在人体组织中积累。在血液和血清样本、脂肪组织和母乳中已经检测到七氯。婴儿暴露于七氯及其代谢物的主要来源似乎是母乳，其中浓度可能远高于牛奶中发现的浓度。在代谢激活和七氯存在的情况下，七氯在人类成纤维细胞中诱导了未计划DNA合成的统计学显著增加，七氯抑制了培养的人类细胞中的接头间细胞通讯。动物/植物/鸟类/甲壳类/鱼类/无脊椎动物研究：在通过饮食、灌胃或皮下注射七氯的动物中，有一个明显的剂量反应曲线导致死亡。在体重和食物消耗方面，处理过的动物与对照组之间没有明显差异。肝脏肿大并伴有明显的叶状突起；组织病理学发现显示中心小叶和中带肝细胞增大。在注射七氯的大鼠中进行生育力研究，结果导致生殖激素水平下降，雌性周期紊乱和交配行为延迟。在发育毒性研究中，通常没有观察到母体毒性（与体重增加相关的剂量相关变化）的临床迹象，直到发生死亡。在一项研究中，观察到窝产仔数减少，仔鼠的产后死亡率是最明显的发现。没有观察到致畸效应。重复给雌性大鼠七氯产生的效应包括活动改变、过度兴奋和自主效应。在大鼠中进行的围产期七氯暴露的神经毒性学研究表明发育迟缓，GABA能神经传递改变和神经行为变化，包括所有剂量的认知缺陷。通过口服给药对多种品系的大鼠和小鼠进行了七氯及其技术等级七氯的致癌性测试。技术等级七氯在雄性和雌性小鼠中显示出致癌性，但在大鼠中没有。已经证明七氯在大鼠中具有神经毒性和免疫毒性。七氯在体外和体内遗传毒性测试中大多显示阴性反应。使用来自不同营养级的多种水生物种测试了七氯的急性毒性。已经证明七氯对鱼类和其他物种有毒。七氯似乎对陆生脊椎动物表现出中等毒性效应。在水鸟、两栖动物、爬行动物、海豹和鲸鱼的组织中发现了七氯。七氯对一系列淡水和海洋物种，包括藻类明显有毒。七氯暴露影响了淡水物种的生长，包括藻类和虾。七氯对鸟类具有中等毒性。

IDENTIFICATION: Heptachlor is a chlorinated dicyclopentadiene insecticide that is persistent in the environment and accumulates in the food chain. Although its use has been banned or severely restricted in many countries since the 1980's, it is still detected as a contaminant in some food commodities. Heptachlor in its pure form at room temperature appears as a white or light tan crystalline solid with a mild camphor or cedar like odor. The technical product is a soft wax. The technical product usually contains about 72% heptachlor and about 28% related compounds such as trans-chlordane (20-22%) and trans-nonachlor (4-8%). HUMAN EXPOSURE: In humans placental transfer of heptachlor has been noted. Available epidemiological data do not show a clear relationship between adverse health effects and exposure to heptachlor. Consumption of foods containing pesticides such as heptachlor leads to an accumulation of these compounds in human tissues. Heptachlor has been detected in blood and serum samples, adipose tissue and breast milk. The most significant source of exposure of infants to heptachlor and its metabolites appears to be breast milk, in which concentrations can be much higher than those found in dairy milk. Heptachlor induced statistically significant increase in unscheduled DNA synthesis in human fibroblasts in the presence of metabolic activation and heptachlor inhibited junctional intracellular communication in cultured human cells. ANIMAL/PLANT/AVIAN/CRUSTACEAN/FISH/INVERTEBRATES STUDIES: In animals fed heptachlor by diet, gavage or sc injection, there is a sharp dose response curve for mortality. No marked differences were seen between treated animals and controls with respect to body weight and food consumption. Liver enlargement has been noted with accentuated lobulation; histopathological findings showed enlargement of centrilobular and midzonal hepatocytes. Fertility studies in rats injected with heptachlor sc resulted in suppression of reproductive hormone levels, disruptions in female cyclicity and delays in mating behavior. In developmental toxicity studies, there were usually no clinical signs of maternal toxicity (dose related alterations in weight gain) until mortality occurred. In one study reduced litter sizes was noted, postnatal mortality of the pups was the most obvious finding. No teratological effects was noted. The profile of effects produced by repeated heptachlor to female rats consisted of altered activity, hyperexcitability and autonomic effects. Neurotoxicological studies on perinatal heptachlor exposure in the rat suggested developmental delays, alterations in GABAergic neurotransmission and neurobehavioral changes which included cognitive deficits at all doses. Heptachlor and technical grade heptachlor have been tested for carcinogenicity by oral administration in several strains of rats and mice. Technical grade heptachlor was shown to be carcinogenic in male and female mice but not in rats. Heptachlor has been shown to be neurotoxic and immunotoxic in rats. Heptachlor shows mostly negative responses in vitro and in vivo genotoxicity testing. The acute toxicity of heptachlor was tested using a variety of aquatic species from different trophic levels. Heptachlor was shown to be toxic to fish and other species. Heptachlor appears to exhibit moderate toxic effects upon terrestrial vertebrates. Heptachlor has been found in tissues of water birds, amphibians, reptiles, seals and whales. Heptachlor is clearly toxic to a range of both freshwater and marine species, including algae. Growth of both freshwater marine species including algae and shrimp was effected by heptachlor exposure. Heptachlor is moderately toxic to birds.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

庚氯是一种中枢神经系统兴奋剂。它通过非竞争性地阻断γ-氨基丁酸受体的神经递质作用，导致神经系统过度兴奋。庚氯还被认为是通过激活信号通路中的关键激酶并抑制凋亡来发挥致癌作用。(L118, A81, A82)

Heptachlor is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

评估：对于氯丹和七氯对人类致癌性的证据不足。对于氯丹和七氯在实验动物中的致癌性有足够的证据。总体评估：氯丹和七氯可能对人类致癌（2B组）。

Evaluation: There is inadequate evidence in humans for the carcinogenicity of chlordane and heptachlor. There is sufficient evidence in experimental animals for the carcinogenicity of chlordane and heptachlor. Overall evaluation: Chlordane and heptachlor are possibly carcinogenic to humans (Group 2B).

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：B2组可能的人类致癌物

Cancer Classification: Group B2 Probable Human Carcinogen

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：B2；可能的人类致癌物。分类依据：人类数据不足，但从三项研究中获得了充分证据，这些研究在两种性别的小鼠三个品系中诱发了良性和恶性肝脏肿瘤。几种结构上相关的化合物是肝脏致癌物。人类致癌性数据：不足。动物致癌性数据：充分。

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Inadequate human data, but sufficient evidence exists from studies in which benign and malignant liver tumors were induced in three strains of mice of both sexes. Several structurally related compounds are liver carcinogens. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

氯化七（Heptachlor）可以通过皮肤、肺和胃肠吸收。在大鼠体内，氯化七会代谢成氯化七环氧物。

Heptachlor can be absorbed through skin & via lung & GI tract. in rat, heptachlor is metabolized to heptachlor epoxide.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

环氧七氯在死产婴儿的血液和脂肪中被发现，这表明它可以通过胎盘转移到胎儿。它还会在人类乳汁中排出。

HEPTACHLOR EPOXIDE IS ... FOUND IN BLOOD & FAT OF STILLBORN INFANTS, INDICATING TRANSPLACENTAL TRANSFER TO THE FETUS. IT IS ALSO EXCRETED IN HUMAN MILK.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

“七氯在大鼠体内迅速转化为七氯环氧物，主要在脂肪组织中积累，在连续给药3-6个月后，这些组织中环氧物的浓度变得稳定（达到稳态）。七氯及其代谢物的排泄主要发生在给药后的前5天，主要通过粪便排出。只有很少一部分通过尿液排出。”

HEPTACHLOR IS RAPIDLY TRANSFORMED IN RATS INTO HEPTACHLOR EPOXIDE, WHICH ACCUMULATES CHIEFLY IN ADIPOSE TISSUES, & AFTER 3-6 MONTHS OF CHRONIC DOSAGE, CONCN OF EPOXIDE IN THOSE TISSUES BECOMES STABILIZED /(REACHES A STEADY STATE)/. EXCRETION OF HEPTACHLOR & ITS METABOLITES OCCURS DURING THE FIRST 5 DAYS AFTER DOSING, CHIEFLY VIA THE FECAL ROUTES. ONLY A ... SMALL AMOUNT IS EXCRETED IN THE URINE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

出栏肉鸡在生命的前8周内以0、0.01、0.03、0.1和0.3毫克/千克的浓度在饲料中添加了七氯。每组牺牲了三只。在所有样本中均发现了七氯残留物。残留物最高浓度出现在脂肪组织中，且浓度与饲料中七氯浓度相关，并在浓度约为饲料中浓度的5倍时达到平台期。七氯与其环氧化物代谢物的浓度比在肌肉脂肪中高于肝脂肪或腹部脂肪。讨论了可能导致各种组织中脂肪残留浓度差异的机制。值得注意的是，停止暴露后大约4周，残留浓度减少了一半。

BROILER CHICKENS WERE GIVEN HEPTACHLOR AT CONCENTRATIONS OF 0, 0.01, 0.03, 0.1 & 0.3 MG/KG IN FEED FOR 1ST 8 WK OF LIFE. THREE WERE SACRIFICED FROM EACH GROUP. HEPTACHLOR RESIDUES WERE FOUND IN ALL SAMPLES. HIGHEST CONCENTRATIONS OF RESIDUES WERE FOUND IN ADIPOSE TISSUE, WHERE CONCENTRATIONS WERE RELATED TO HEPTACHLOR CONCN IN FEED & PLATEAUED AT CONCENTRATIONS ABOUT 5 TIMES GREATER THAN THOSE IN FEED. RATIO OF CONCN OF HEPTACHLOR TO ITS EPOXIDE METABOLITE WAS HIGHER IN MUSCLE FAT THAN IN HEPATIC OR ABDOMINAL FAT. POSSIBLE MECHANISMS ACCOUNTING FOR DISPARITY OF RESIDUE CONCENTRATIONS IN FAT FROM VARIOUS TISSUES ARE DISCUSSED. IT IS NOTED THAT RESIDUE CONCENTRATIONS WERE DEPLETED BY HALF AT APPROX 4 WK AFTER CESSATION OF EXPOSURE.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xn,F,T,N
• 安全说明：
  S16,S36/37,S45,S60,S61,S62,S7
• 危险类别码：
  R67,R38,R40,R33,R24/25,R50/53,R11,R23/24/25,R39/23/24/25,R65
• RTECS号：
  PC0700000
• 海关编码：
  2903820010
• 包装等级：
  II
• 危险类别：
  6.1(a)
• 危险品运输编号：
  UN 2761

SDS

第一部分：化学品名称

制备方法与用途

制备方法： 由六氯环戊二烯与环戊二烯的加成反应产生并经氯化得到。

合成制备方法： 同样是由六氯环戊二烯与环戊二烯的加成反应生成，随后进行氯化处理。

用途简介： 这是一种非内吸性触杀、胃毒性杀虫剂，并具有一定的熏蒸作用。通常加工成乳剂或可湿性粉剂使用。曾广泛用于土壤处理、拌种或喷施于植物表面以防治多种害虫，但现已不再使用。

用途： 它是一种非内吸性触杀和胃毒性杀虫剂，具备一定熏蒸效果，常被制成乳剂或可湿性粉剂应用。过去主要用于土壤处理、种子拌种或植株喷施来防控多种害虫，如今已被淘汰。

反应信息

• 作为反应物：
  描述：

  七氯 、 水 生成 1,3,4,7,8,9,10,10-octachlorotricyclo[5.2.1.02,6]dec-8-en-3-ol
  参考文献：
  名称：

  PIRBAZARI, MASSOUD;BADRIYHA, BADRI N.;MILTNER, RICHARD J., J. ENVIRON. ENC., 117,(1991) N, C. 80-100

  摘要：

  DOI：
• 作为产物：
  描述：

  1-羟基氯丹 生成 七氯
  参考文献：
  名称：

  KLEEMEYER, H.;THIEMANN, W., CHEMOSPHERE, 1986, 15, N 6, 687-692

  摘要：

  DOI：

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• COMPOSITIONS AND METHODS FOR INHIBITING CELLULAR ADHESION OR DIRECTING DIAGNOSTIC OR THERAPEUTIC AGENTS TO RGD BINDING SITES
  申请人：Allegro Pharmaceuticals, LLC

  公开号：US20160022763A1

  公开（公告）日：2016-01-28

  Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH—CH(CH 2 —SO 3 H)COOH or Arg-Gly-NH—CH(CH 2 —SO 3 H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers, multimers, cyclic forms, linear forms, drug-conjugates, pro-drugs and their derivatives. Also disclosed are methods for making and using such compounds including methods for inhibiting cellular adhesion to RGD binding sites or delivering other diagnostic or therapeutic agents to RGD binding sites in human or animal subjects.

  包括R-G-半胱氨酸（即R-G-NH—CH(CH2—SO3H)COOH或Arg-Gly-NH—CH(CH2—SO3H)COOH）及其衍生物在内的化合物，包括药用可接受的盐、水合物、立体异构体、多聚体、环形形式、线形形式、药物结合物、前药及其衍生物。还公开了制备和使用这类化合物的方法，包括用于抑制细胞对RGD结合位点的粘附或将其他诊断或治疗剂递送到人类或动物主体中的RGD结合位点的方法。
• THIENYLPYRIDYLCARBOXAMIDES
  申请人：Dunkel Ralf

  公开号：US20110105564A1

  公开（公告）日：2011-05-05

  Novel thienylpyridylcarboxamides of the formula (I) The present application is also directed to a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.

  新型噻吩基吡啶基羧酰胺的化学式（I） 本申请还涉及多种制备这些化合物的方法，以及它们用于控制不受欢迎的微生物的用途，还有新颖的中间体及其制备。
• [EN] TREATMENT OF ANXIETY DISORDERS AND AUTISM SPECTRUM DISORDERS<br/>[FR] TRAITEMENT DES TROUBLES DE L'ANXIÉTÉ ET DES TROUBLES DU SPECTRE AUTISTIQUE
  申请人：RUGEN HOLDINGS CAYMAN LTD

  公开号：WO2016049048A1

  公开（公告）日：2016-03-31

  Disclosed are methods for treating autism spectrum disorders and/or anxiety disorders by administering certain NR2B subunit-selective NMDA (N methyl-D aspartate) antagonists. Anxiety disorders include agoraphobia (with or without panic disorder), generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD).

  本文披露了通过给予特定NR2B亚单位选择性NMDA（N-甲基-D-天冬氨酸）拮抗剂来治疗自闭症谱系障碍和/或焦虑障碍的方法。焦虑障碍包括广场恐惧症（伴有或不伴有惊恐障碍）、广泛性焦虑障碍（GAD）、社交焦虑障碍（SAD）、惊恐障碍（PD）、创伤后应激障碍（PTSD）和强迫症（OCD）。

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