3-Nitro-4-[(2,2,5-trimethyl-1,3-dioxane-5-carbonyl)oxymethyl]benzoic acid | 1428955-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Nitro-4-[(2,2,5-trimethyl-1,3-dioxane-5-carbonyl)oxymethyl]benzoic acid
• 英文别名: 3-nitro-4-[(2,2,5-trimethyl-1,3-dioxane-5-carbonyl)oxymethyl]benzoic acid
• CAS: 1428955-93-4
• 化学式: C₁₆H₁₉NO₈
• 分子量: 353.329
• InChiKey: WMXGLTKBSJWCHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzyl alcohol 、 3-Nitro-4-[(2,2,5-trimethyl-1,3-dioxane-5-carbonyl)oxymethyl]benzoic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以89%的产率得到[2-Nitro-4-[[3,4,5-tris[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]methoxycarbonyl]phenyl]methyl 2,2,5-trimethyl-1,3-dioxane-5-carboxylate
  参考文献：
  名称：

  Dendrimersomes with photodegradable membranes for triggered release of hydrophilic and hydrophobic cargo

  摘要：

  合成了具有完全光降解疏水块的两性Janus树状聚合物，并在水中组装成树状体。紫外光照射触发了疏水和亲水货物的释放。

  DOI：

  10.1039/c4cc05161k
• 作为产物：
  描述：

  4-溴甲基-3-硝基苯甲酸 在 哌啶 、 4-二甲氨基吡啶 、 四(三苯基膦)钯 、 caesium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 3-Nitro-4-[(2,2,5-trimethyl-1,3-dioxane-5-carbonyl)oxymethyl]benzoic acid
  参考文献：
  名称：

  Synthesis and Degradation of Backbone Photodegradable Polyester Dendrimers

  摘要：

  Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated that the molecules degrade to release bis-MPA. The accessibility of these molecules opens new avenues for the preparation of well-defined, fully photodegradable materials.

  DOI：

  10.1021/ol4004367

文献信息

• Synthesis and Degradation of Backbone Photodegradable Polyester Dendrimers
  作者：Ali Nazemi、Tyler B. Schon、Elizabeth R. Gillies

  DOI：10.1021/ol4004367

  日期：2013.4.19

  Dendrimers with fully photodegradable backbones were synthesized through the incorporation of photodegradable o-nitrobenzyl esters into a new dendrimer monomer based on 2,2-bis(hydroxymethyl)propionic acid (bis-MPA). Dendrons were synthesized using a divergent approach, and were subsequently coupled to a core molecule in the final step. Photodegradation was performed and it was demonstrated that the molecules degrade to release bis-MPA. The accessibility of these molecules opens new avenues for the preparation of well-defined, fully photodegradable materials.
• Dendrimersomes with photodegradable membranes for triggered release of hydrophilic and hydrophobic cargo
  作者：Ali Nazemi、Elizabeth R. Gillies

  DOI：10.1039/c4cc05161k

  日期：——

  Amphiphilic Janus dendrimers with fully photodegradable hydrophobic blocks were synthesized and assembled into dendrimersomes in water. Irradiation with UV light triggered the release of hydrophobic and hydrophilic cargo.

  合成了具有完全光降解疏水块的两性Janus树状聚合物，并在水中组装成树状体。紫外光照射触发了疏水和亲水货物的释放。