1-(5-bromomethyl-2-nitrophenyl)-ethanol | 99821-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(5-bromomethyl-2-nitrophenyl)-ethanol
• 英文别名: 1-[5-(bromomethyl)-2-nitrophenyl]ethanol
• CAS: 99821-60-0
• 化学式: C₉H₁₀BrNO₃
• 分子量: 260.087
• InChiKey: ANAKDFJXJLPTGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5-bromomethyl-2-nitrophenyl)-ethanol 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以88%的产率得到1-(5-(azidomethyl)-2-nitrophenyl)ethan-1-ol
  参考文献：
  名称：

  Convenient RNA Synthesis Using a Phosphoramidite Possessing a Biotinylated Photocleavable Group

  摘要：

  A convenient RNA synthesis using a biotin streptavidin interaction and a photocleavable protecting group is described. The biotinylated photocleavable group was introduced at the 2'-position of the uridine derivative. Using the phosphoramidite 12, we attempted the synthesis of a 21mer RNA, which is pure enough to show potent RNAi activity compared with a conventionally prepared and HPLC-purified 21mer RNA with the same sequence.

  DOI：

  10.1021/ol101489v
• 作为产物：
  描述：

  5-甲基-2-硝基苯甲酰氯 在 甲醇 、 sodium tetrahydroborate 、 N-溴代丁二酰亚胺(NBS) 、 三乙胺 、 1,1'-偶氮(氰基环己烷) 作用下， 以 1,4-二氧六环 、 乙酸乙酯 、 乙腈 为溶剂， 反应 25.25h， 生成 1-(5-bromomethyl-2-nitrophenyl)-ethanol
  参考文献：
  名称：

  [EN] METHOD AND COMPOUND
  [FR] PROCÉDÉ ET COMPOSÉ

  摘要：

  Provided herein is a method for modifying a polynucleotide or an analogue or derivative thereof, comprising reacting the polynucleotide or analogue or derivative thereof with a compound of formula (I), wherein RH, L1, Ⓛ, R, n and RPare as defined herein. Also provided are associated methods for purifying a polynucleotide or analogue or derivative thereof, uses of a compound of formula (I), and such compounds per se.

  公开号：

  WO2023180237A1

文献信息

• Cell-delivery agent
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US04625014A1

  公开（公告）日：1986-11-25

  A photo-cleavable compound for delivery and release of a biologically active substance to selected target cells; the compound includes a binding partner for a specific cell-surface receptor of those target cells, the biologically active substance to be delivered, and a photo-cleavable bridge between the binding partner and the biologically active substance. When the compound is exposed to a heterogeneous population of target and non-target cells, it binds selectively to the receptors on the surface of the target cells. Exposing the compound to light of selected wave length cleaves it, yielding the active substance.

  一种用于将生物活性物质传递和释放到特定靶细胞的光解化化合物；该化合物包括与靶细胞表面特定细胞受体结合的结合伴侣、要传递的生物活性物质以及连接结合伴侣和生物活性物质的光解桥。当将化合物暴露于异质目标和非目标细胞的群体时，它选择性地结合到靶细胞表面的受体上。将该化合物暴露于特定波长的光线下，将其裂解，产生活性物质。
• Electrochemical Assay
  申请人：Williams David Edward

  公开号：US20090035876A1

  公开（公告）日：2009-02-05

  A method of determining the presence or amount of analyte in a fluid sample, which comprises: contacting a fluid sample with a binding reagent that comprises a plurality of cleavable species and wherein said species, when cleaved, are detectable using electrochemical means; separating any binding reagent-analyte complex that forms from the unbound binding reagent; cleaving the cleavable species from the immobilized binding reagent-analyte complex; and detecting the cleaved species using electrochemical means.

  一种测定流体样品中分析物存在或数量的方法，包括：将流体样品与包含多个可裂解物种的结合试剂接触，其中当裂解时，这些物种可使用电化学手段检测；分离任何形成的结合试剂-分析物复合物与未结合的结合试剂；从固定化的结合试剂-分析物复合物中裂解可裂解物种；并使用电化学手段检测已裂解的物种。
• Chemical reagents and methods for detection and quantification of proteins in complex mixtures
  申请人：——

  公开号：US20040038319A1

  公开（公告）日：2004-02-26

  The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the invention. The methods can be used to label a polypeptide in a sample by contacting a sample with a reagent of the invention under conditions allowing the reactive group to bind to one or more polypeptides in the sample. The invention additionally provides methods of isolating, identifying and quantifying a polypeptide in a sample. The invention further provides methods of diagnosing a disease using a reagent of the invention.

  本发明提供了一种试剂，该试剂由亲和性标签、可检测分子、连接体、同位素标签和反应基团组成。本发明还提供了使用本发明试剂的方法。在允许反应基团与样品中的一个或多个多肽结合的条件下，将样品与本发明的试剂接触，即可使用这些方法标记样品中的多肽。本发明还提供了分离、鉴定和量化样品中多肽的方法。本发明进一步提供了使用本发明试剂诊断疾病的方法。
• CELL-DELIVERY AGENT
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：EP0185762B1

  公开（公告）日：1991-03-13
• Controlling RNA Digestion by RNase H with a Light-Activated DNA Hairpin
  作者：XinJing Tang、Ivan J. Dmochowski

  DOI：10.1002/anie.200600954

  日期：2006.5.19