N-monoethyl-1,8-diaminooctane | 205689-46-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-monoethyl-1,8-diaminooctane
• 英文别名: N'-ethyloctane-1,8-diamine
• CAS: 205689-46-9
• 化学式: C₁₀H₂₄N₂
• 分子量: 172.314
• InChiKey: HXWFGHGEFGXRCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,8-辛二胺 、 乙酸酐 、 Lithium aluminium hydride 在 N-monoacetoamide 1,8-diaminooctane 、 1,2-二氯乙烷 、 氮 、 氯化钠 、 magnesium sulfate 作用下， 以 吡啶 、 乙酸乙酯 为溶剂， 反应 24.0h， 以to produce a residue of N-monoethyl-1,8-diaminooctane的产率得到N-monoethyl-1,8-diaminooctane
  参考文献：
  名称：

  Pharmaceutical compounds comprising polyamines substituted with

  摘要：

  提供了一种包含至少2个电子亲和基团的聚胺化合物或其盐。在首选实施例中，聚胺化合物具有以下结构：其中：A是间隔物；R.sup.1，R.sup.2，R.sub.3和R.sub.4分别是氢，碳氢化合物，杂原子取代的碳氢化合物，杂环基，杂原子取代的杂环基或含有取代基的电子亲和基团；且该化合物含有至少一个三级胺官能团，其三个取代基分别独立地含有至少一个电子亲和基团或亲水基团。

  公开号：

  US06060604A1

文献信息

• 12-EPI PLEUROMUTILINS
  申请人：NABRIVA THERAPEUTICS AG

  公开号：US20160332963A1

  公开（公告）日：2016-11-17

  A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

  从14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-硫基)-乙酰基]-12-epi-木替林，或14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-氧基)-乙酰基]-12-epi-木替林中选择的一种化合物，其中12-epi-木替林的特征在于木替林环在位置12被两个取代基取代，木替林环在位置12的第一个取代基是一个甲基基团，该甲基基团的立体化学与天然存在的普鲁木替林环在位置12的甲基基团的立体化学相反，木替林环在位置12的第二个取代基是一个含有至少一个氮原子的碳氢基团，木替林环的所有其他取代基与天然存在的普鲁木替林环中相应位置的取代基的立体化学相同；可选地以盐和/或溶剂的形式存在，其中天然存在的普鲁木替林的化学式为 制备这类化合物的方法以及它们作为药物的用途。
• Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups and method of application thereof
  申请人：Florida State University

  公开号：US06255495B1

  公开（公告）日：2001-07-03

  A compound comprising and diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has the formula wherein A comprises a carbon carbon having from about 2-10 carbon in the chain, R1, R2, R3, and R4 are H, or T, T is wherein A′ comprises a carbon chain having from about 1-8 carbon in the chain, is R5 is H, lower alkyl, and halo, and R6 is H, lower alkyl, halo or nitro, provided that at least one of R1 and R2, and at least one of R3 and R4 is T. Intermediates for, pharmaceutical compositions containing, methods for making and methods for using such compounds to radiosensitize and kill hypoxic tumor cells are also provided.

  提供了一种化合物，其中包含2-4个具有电子亲和性放射增敏功能基团的二胺或其盐。在首选实施例中，该化合物的式子为：其中A包括具有大约2-10个碳的碳链，R1、R2、R3和R4为H或T，T为其中A'包括具有大约1-8个碳的碳链，R5为H、低碳基、卤素，R6为H、低碳基、卤素或硝基，但R1和R2中至少有一个，以及R3和R4中至少有一个为T。还提供了制备中间体、含有药物组成的制剂、制备和使用这种化合物来增敏和杀死缺氧肿瘤细胞的方法。
• Thermoplastic resin composition
  申请人：IDEMITSU PETROCHEMICAL COMPANY LIMITED

  公开号：EP0558048A1

  公开（公告）日：1993-09-01

  There is disclosed a thermoplastic resin composition comprising as principal components a [A] thermoplastic resin having a functional group reactive with an amino group, a [B] olefinic polymer and/or styrenic polymer, the subtotal of the above [A]+[B] being 100 parts by weight, and 0.05 to 20 parts by weight of a [C] copolymer having in a molecule thereof a formamide group and/or an amino group or a salt thereof, said copolymer having the repeating unit I, II, III or IV represented by the general formula (I), (II), (III) or (IV), respectively, wherein Y is a group selected from the general formula         -NH-R¹³   (VII) and other symbols are as defined in the specification. The above composition is excellent in impact characteristics, especially surface impact characteristics and appearance, minimized in coloration and free from delamination and peeling.

  本发明公开了一种热塑性树脂组合物，其主要成分包括具有与氨基反应的官能团的[A]热塑性树脂、[B]烯烃聚合物和/或苯乙烯聚合物，上述[A]+[B]的小计为100份（重量），以及0.05 至 20 重量份的[C]共聚物，其分子中含有甲酰胺基和/或氨基或其盐，所述共聚物具有分别由通式(I)、(II)、(III)或(IV)表示的重复单元 I、II、III 或 IV、 其中 Y 是选自通式的基团 -NH-R¹³（VII） 和其他符号在说明书中定义。上述组合物具有优异的抗冲击特性，尤其是表面抗冲击特性和外观，着色少，无分层和剥落。
• Copolymer having amino group and process for production thereof
  申请人：DAI-ICHI KOGYO SEIYAKU Co., Ltd.

  公开号：EP0558047A2

  公开（公告）日：1993-09-01

  There are disclosed a copolymer having a secondary amino group such as an alkylpiperazino group or having a formamide group which is introduced via imide group in the side chains of various high polymers and a process for producing the above copolymer by reacting a starting copolymer having the repeating unit originating from an acid anhydride (e.g. maleic anhydride) with a salt of a specific amine (e.g. piperazine derivative) in the presence or absence of a formyl group-containing compound (e.g. formamide) to imidize the starting copolymer and further removing the acid with a base, or by imidizing the starting copolymer with the reaction product between the specific amine and the formyl group-containing compound. The above copolymer is usable for high molecular amino reagents, raw materials for functional high polymers, raw materials for additives, compatibilizers for polymers, resin dyeing improvers, epoxy resin curing agent, resin modifiers, etc.

  本发明公开了一种具有烷基哌嗪基等仲氨基或具有甲酰胺基的共聚物，该共聚物通过酰亚胺基引入到各种高聚物的侧链中，并公开了一种生产上述共聚物的工艺，该工艺是将具有源自酸酐（如马来酸酐）的重复单元的起始共聚物与特定胺盐（如哌嗪衍生物）在存在或不存在含甲酰基化合物（如甲酰胺）的情况下进行反应，使其酰亚胺化，从而生产出上述共聚物。马来酸酐）与特定胺（如哌嗪衍生物）的盐在含甲酰基化合物（如甲酰胺）存在或不存在的情况下进行反应，使起始共聚物酰亚胺化，并用碱进一步除去酸，或用特定胺与含甲酰基化合物的反应产物使起始共聚物酰亚胺化。上述共聚物可用于高分子氨基试剂、功能性高聚物原料、添加剂原料、聚合物相容剂、树脂染色改良剂、环氧树脂固化剂、树脂改性剂等。
• MODIFIED BLOCK COPOLYMER, METHOD FOR PRODUCING MODIFIED BLOCK COPOLYMER, AND RESIN COMPOSITION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3623398A1

  公开（公告）日：2020-03-18

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x = 0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x = 0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x = 0 to 2) (C) satisfies the following condition: Condition: when the compound forming the atomic group having NHx (x = 0 to 2) (C) is reacted with a maleic anhydride-modified group in a maleic anhydride-modified block copolymer, a MFR value at 230°C under a load of 2.16 kg of the modified block copolymer after the reaction is 0.1 times or more a MFR value at 230°C under a load of 2.16 kg of the maleic anhydride-modified block copolymer before the reaction.

  根据本发明，改性嵌段共聚物是一种改性嵌段共聚物，包括以乙烯基芳香族化合物为主要成分的聚合物嵌段（A）、以共轭二烯化合物为主要成分的聚合物嵌段（B）和具有 NHx（x = 0 至 2）的原子团（C）。在改性嵌段聚合物中，由共轭二烯化合物作为主要成分（B）的聚合物嵌段是氢化产物，具有 NHx（x = 0 至 2）（C）的原子团包含在侧链中，形成具有 NHx（x = 0 至 2）（C）的原子团的化合物满足以下条件： 条件：当形成具有 NHx（x = 0 至 2）(C)的原子团的化合物与马来酸酐改性嵌段共聚物中的马来酸酐改性基团反应时，反应后在 230℃、负载 2.16 千克改性嵌段共聚物时的 MFR 值是反应前在 230℃、负载 2.16 千克马来酸酐改性嵌段共聚物时的 MFR 值的 0.1 倍或以上。