7-碘-9H-芴-4-羧酸 | 16218-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 7-碘-9H-芴-4-羧酸
• 英文名称: 2-Jod-fluoren-5-carbonsaeure
• 英文别名: 7-iodo-9H-fluorene-4-carboxylic acid
• CAS: 16218-33-0
• 化学式: C₁₄H₉IO₂
• mdl: MFCD00829127
• 分子量: 336.129
• InChiKey: CUQWLXGXIQEWQY-UHFFFAOYSA-N

物化性质

• 熔点：
  265 °C
• 沸点：
  502.0±43.0 °C(Predicted)
• 密度：
  1.837±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2916399090

反应信息

• 作为产物：
  描述：

  芴-4-羧酸 在 硫酸 、 碘 、 硝酸 、 溶剂黄146 作用下， 生成 7-碘-9H-芴-4-羧酸
  参考文献：
  名称：

  Slyusarchuk,V.T.; Novikov,A.N., Journal of Organic Chemistry USSR (English Translation), 1967, vol. 3, p. 1283 - 1285

  摘要：

  DOI：

文献信息

• LOW AFFINITY SCREENING METHOD
  申请人：Graffinity Pharmaceuticals Aktiengesellschaft

  公开号：EP1360489A1

  公开（公告）日：2003-11-12
• Low affinity screening method
  申请人：——

  公开号：US20040082079A1

  公开（公告）日：2004-04-29

  A parallel high throughput screening method on a solid support is disclosed that allows the detection of low affinity binding partners, comprising the steps of:(a) providing a library of different ligands;(b) forming a binding matrix comprising the ligands on a solid support by immobilising said ligands on the support; (c) contacting a target of interest with said binding matrix; (d) parallely determining a binding value of the ligand/target interaction for each type of ligand comprised in the binding matrix; (e) selecting those ligands the binding value of which in an immobilised state towards the target exceeds a predetermined threshold; (f) evaluating the affinity of each of the ligands selected in step (e) in a non-immobilised state towards the target; (g) identifying at least one ligand of step (f) as low affinity binding ligand.
• [EN] LOW AFFINITY SCREENING METHOD<br/>[FR] PROCEDE DE CRIBLAGE DES FAIBLES AFFINITES
  申请人：GRAFFINITY PHARM DESIGN GMBH

  公开号：WO2002063299A1

  公开（公告）日：2002-08-15

  A parallel high throughput screening method on a solid support is disclosed that allows the detection of low affinity binding partners, comprising the steps of:(a) providing a library of different ligands;(b) forming a binding matrix comprising the ligands on a solid support by immobilising said ligands on the support; (c) contacting a target of interest with said binding matrix; (d) parallely determining a binding value of the ligand/target interaction for each type of ligand comprised in the binding matrix; (e) selecting those ligands the binding value of which in an immobilised state towards the target exceeds a predetermined threshold; (f) evaluating the affinity of each of the ligands selected in step (e) in a non-immobilised state towards the target; (g) identifying at least one ligand of step (f) as low affinity binding ligand.