1-ethoxy-4-(1-propenyl)benzene | 4223-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-ethoxy-4-(1-propenyl)benzene
• 英文别名: Ethoxy-4-propenylbenzol；4-propenyl-phenetole；4-Propenyl-phenetol；4-Aethoxy-1-propenyl-benzol；α-(4-Aethoxy-phenyl)-α-propylen；p-Propenyl-phenetol；Anaethol；1-Ethoxy-4-prop-1-enylbenzene
• CAS: 4223-19-2
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: MKFWKDNSZLCLDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-ethoxy-4-(1-propenyl)benzene 在 乙醇 、 sodium 作用下， 生成 4-propylethoxybenzene
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 1-ethoxy-4-(1-propenyl)benzene
  参考文献：
  名称：

  Klages, Chemische Berichte, 1902, vol. 35, p. 2263

  摘要：

  DOI：

文献信息

• Moderately Oxidizing Thioxanthylium Organophotoredox Catalysts for Radical-Cation Diels–Alder Reactions
  作者：Kenta Tanaka、Mami Kishimoto、Yuta Tanaka、Yusuke Kamiyama、Yosuke Asada、Mayumi Sukekawa、Naoya Ohtsuka、Toshiyasu Suzuki、Norie Momiyama、Kiyoshi Honda、Yujiro Hoshino

  DOI：10.1021/acs.joc.1c02972

  日期：2022.3.4

  have been developed. These catalysts exhibit relatively moderate excited-state reduction potentials [E1/2(C*/C•–) = 1.75–1.94 V vs saturated calomel electrode (SCE)] and can efficiently promote radical-cation Diels–Alder reactions under irradiation with green light. Interestingly, β-halogenostyrenes (Ep/2 = 1.57–1.61 V vs SCE) are well tolerated, affording synthetically useful halocyclohexenes.

  已经开发出在绿光照射下工作的中度氧化的硫氧杂草光氧化还原催化剂。这些催化剂表现出相对适中的激发态还原电位 [ E 1/2 (C*/C •– ) = 1.75–1.94 V vs 饱和甘汞电极 (SCE)] 并且可以有效地促进自由基阳离子 Diels-Alder 反应。绿灯。有趣的是，β-卤代苯乙烯（E p/2 = 1.57–1.61 V vs SCE）具有良好的耐受性，可提供合成有用的卤代环己烯。
• Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats
  作者：Alexander V Gourine、Ekaterina V Melenchuk、Dmitry M Poputnikov、Valery N Gourine、K Michael Spyer

  DOI：10.1038/sj.bjp.0704679

  日期：2002.4

  P2 purinoreceptors are present in hypothalamic and brainstem nuclei that are involved in the regulation of body temperature (Tb). The role of ATP acting on these P2 receptors in thermoregulation was investigated by studying the effects of the stable ATP analogue α,β‐methyleneATP (α,β‐meATP) and P2 receptor antagonists suramin and pyridoxal‐5′‐phosphate‐6‐azophenyl‐2′,4′‐disulphonic acid (PPADS) on Tb when injected intracerebroventricularly (i.c.v.) via a pre‐implanted cannula in conscious rats at various ambient temperatures and during lipopolysaccharide (LPS)‐induced fever. Depending on ambient temperature, α,β‐meATP (0.2 μmol, i.c.v.) induced a fall in Tb (−3.3°C, P<0.05), no changes in Tb when compared to pre‐injection levels, or an increase in Tb (∼1.0°C, P<0.05) in rats maintained at 10°C, 25°C and 30°C ambient temperature, respectively. Suramin (7 nmol, i.c.v.) induced a lasting (up to 6 h) increase in Tb (on average 1.2°C, P<0.05) in rats kept at 25°C or 30°C, but failed to induce any rise in Tb in rats at 10°C ambient temperature. An increase in Tb was also observed in rats (25°C ambient temperature) treated with PPADS (0.2 μmol, i.c.v.). α,β‐meATP (0.2 μmol) injected i.c.v. or directly into the anterior hypothalamus caused a profound fall in Tb (by 0.9°C and 1.0°C, respectively; P<0.05) during LPS (E.coli; 50 μg kg−1)‐induced fever in rats at 25°C ambient temperature. Fever was initiated more rapidly in rats treated with suramin (7 nmol) or PPADS (70 nmol), however its late phase was unaffected. Suramin (7 nmol) and PPADS (70 nmol) injected at the time when fever was already developed (2.5 h after LPS injections) did not alter febrile Tb. These data indicate that purinergic signalling may play a significant role in central mechanisms of Tb regulation at various ambient temperatures and during fever. British Journal of Pharmacology (2002) 135, 2047–2055; doi:10.1038/sj.bjp.0704679

  在下丘脑和脑干核中存在P2嘌呤受体，这些核团参与了体内温度调节（Tb）。研究了ATP作用于这些P2受体在体温调节中的作用，方法是通过预先植入的导管将稳定的ATP类似物α,β-甲基ATP（α,β-meATP）和P2受体拮抗剂suramin及吡哆醛-5′-磷酸-6-偶氮苯基-2′,4′-二磺酸（PPADS）直接注入清醒大鼠脑室内（i.c.v.），在不同环境温度下及脂多糖（LPS）诱导的发热过程中观察其对Tb的影响。根据环境温度的不同，α,β-meATP（0.2 μmol，i.c.v.）在分别维持在10°C、25°C和30°C环境温度的大鼠中，诱导Tb下降（-3.3°C，P < 0.05），或与注射前水平无变化，或Tb升高（约1.0°C，P < 0.05）。suramin（7 nmol，i.c.v.）在25°C或30°C环境下使Tb持续升高（平均升高1.2°C，P < 0.05），时间长达6小时；但在10°C环境温度下未能引起Tb升高。在25°C环境温度下PPADS（0.2 μmol，i.c.v.）处理的大鼠中也观察到了Tb升高。α,β-meATP（0.2 μmol）在i.c.v.或直接注入前下丘脑时，在25°C环境温度下E. coli（50 μg kg−1）诱导的发热大鼠模型中，引起明显的Tb下降（分别为0.9°C和1.0°C，P < 0.05）。接受suramin（7 nmol）或PPADS（70 nmol）处理的动物，发热启动更快，但其发热的后期阶段不受影响。当在发热已经发生（LPS注射后2.5小时）时给予suramin（7 nmol）或PPADS（70 nmol），则未改变发热状态下的Tb。这些数据表明，嘌呤信号传递可能在各种环境温度下及发热过程中的体温调节中枢机制中发挥重要作用。英国药理学杂志 (2002) 135, 2047–2055; doi:10.1038/sj.bjp.0704679
• DE154654
  申请人：——

  公开号：——

  公开（公告）日：——
• van der Zanden, Recueil des Travaux Chimiques des Pays-Bas, 1939, vol. 58, p. 181,189
  作者：van der Zanden

  DOI：——

  日期：——
• Klages, Chemische Berichte, 1902, vol. 35, p. 2263
  作者：Klages

  DOI：——

  日期：——