N-(5-bromothiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide | 840493-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-bromothiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide
• 英文别名: N-(5-bromo-1,3-thiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide
• CAS: 840493-90-5
• 化学式: C₁₄H₁₅BrN₂OS
• 分子量: 339.256
• InChiKey: UKJQIDNQYNSXIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 N-(5-bromothiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以69%的产率得到N-(4-bromo-5-trimethylsilylthiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326
• 作为产物：
  描述：

  N-苯基-1,3-噻唑-2-胺 在 溴 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 3.0h， 生成 N-(5-bromothiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326

文献信息

• Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines
  作者：Peter Stanetty、Michael Schnürch、Kurt Mereiter、Marko D. Mihovilovic

  DOI：10.1021/jo0484326

  日期：2005.1.1

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.