2-(4-Chlorophenyl)-5-methyl-3-oxopyridazine-4-carbonitrile | 1001396-84-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(4-Chlorophenyl)-5-methyl-3-oxopyridazine-4-carbonitrile
• CAS: 1001396-84-4
• 化学式: C₁₂H₈ClN₃O
• 分子量: 245.668
• InChiKey: HIJAWDRSOKFAJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Chlorophenyl)-5-methyl-3-oxopyridazine-4-carbonitrile 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 以66%的产率得到7-amino-2-(4-chlorophenyl)furo[3,4-d]pyridazin-1(2H)-one
  参考文献：
  名称：

  A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(iii) complex as promoter for alkyl oxidation reactions

  摘要：

  一种新颖、高效且可循环利用的生物催化剂用于Michael加成反应，以及其铁（III）配合物作为烷基氧化反应的催化剂。

  DOI：

  10.1039/c5cy01034a

文献信息

• Chitosan Based Heterogeneous Catalyses: Chitosan-Grafted-Poly(4-Vinylpyridne) as an Efficient Catalyst for Michael Additions and Alkylpyridazinyl Carbonitrile Oxidation
  作者：Khaled Khalil、Hamad Al-Matar

  DOI：10.3390/molecules18055288

  日期：——

  be synthesized under heterogeneous conditions in presence of a potassium persulfate and sodium sulfite redox system. The synthesized graft copolymer could be utilized effectively, in the form of beads, as an efficient catalyst for Michael additions of active methylenes to functionally substituted alkenes. Moreover, methyl moiety oxidation in methyl pyridazinyl carbonitriles by H2O2 in the presence of

  壳聚糖接枝聚（4-乙烯基吡啶）（Cs-PVP）共聚物可以在过硫酸钾和亚硫酸钠氧化还原系统存在的非均相条件下合成。合成的接枝共聚物可以以珠的形式有效地用作活性亚甲基与官能取代烯烃的迈克尔加成反应的有效催化剂。此外，在壳聚糖-g-聚乙烯吡啶负载的铁 (III) 配合物 Cs-PVP/Fe 存在下，H2O2 对甲基哒嗪基腈中的甲基部分氧化可能会受到影响。在这些接枝共聚物珠的存在下，可以通过新的催化途径有效地合成各种吡喃、萘并吡喃和噻喃。这些聚合物催化剂可以用来代替旧的有毒的商业有机碱性催化剂，哌啶或吡啶，
• Studies using (E)-6-oxo-1-aryl-4-(2-N-Piperidinyl)vinyl-1,6-dihydropyridazine-5-carbonitrile
  作者：I ABDELHAMID、S SOLIMANGHOZLAN、H KOLSHORN、H MEIER、M ELNAGDIA

  DOI：10.1016/s0385-5414(07)81199-3

  日期：2007.12.1

  Condensing 1-aryl-4-methyl-1,6-dihydropyridazine-5carbonitrile with triethyl orthoformate and piperidine afforded the trans-enamine 2. This could be converted into pyrido[3,4-d]pyridazine 3 upon treatment with primary aromatic amines. Reacting 2 with hydrazonoyl chlorides 5 afforded 7 rather than 6. Compound 2 gives also pyrido[3,4-d]pyridazine 10 upon treatment with acetic acid and ammonium acetate. Compound 2 afforded N-aminopyrido[3,4-dlpyridazine 11 upon treatment with hydrazine hydrate. Compound 11 reacted with triethyl orthoformate to give [1,2,4]triazolo[2',3':1,2]pyrido[4,3-d]pyridazin-10-one 12 and can be acetylated to 13. Compound 2 could be coupled with p-chlorobenzenediazonium chloride to give the pyridazino[4,5-d]pyridazine 17.
• A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(<scp>iii</scp>) complex as promoter for alkyl oxidation reactions
  作者：Khaled D. Khalil、Enas I. Ibrahim、Fakhreia A. Al-Sagheer

  DOI：10.1039/c5cy01034a

  日期：——

  A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(iii) complex as promoter for alkyl oxidation reactions.

  一种新颖、高效且可循环利用的生物催化剂用于Michael加成反应，以及其铁（III）配合物作为烷基氧化反应的催化剂。