2-ethyl-6-sec-butyl-4-methyl-phenol | 108018-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-ethyl-6-sec-butyl-4-methyl-phenol
• 英文别名: 2-Aethyl-6-sec-butyl-4-methyl-phenol；2-Butan-2-yl-6-ethyl-4-methylphenol
• CAS: 108018-98-0
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: RSMLJPNOGAOZMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对甲酚 、 乙烯 在 aluminium tris(p-methylphenoxide) 作用下， 生成 2-ethyl-6-sec-butyl-4-methyl-phenol
  参考文献：
  名称：

  Stroh et al., Angewandte Chemie, 1957, vol. 69, p. 699,700

  摘要：

  DOI：

文献信息

• Local vascular delivery of mTor inhibitors in combination with peroxisome proliferators-activated receptor stimulators
  申请人：Cordis Corporation

  公开号：EP2042202A2

  公开（公告）日：2009-04-01

  Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and athereosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

  医疗器械，尤其是植入式医疗器械，可以进行涂层处理，以尽量减少或基本消除生物体对医疗器械进入生物体后的反应。医疗器械可涂覆各种生物相容性材料。治疗药物、药剂或化合物可与生物相容性材料混合，并粘附在医疗设备的至少一部分上。这些治疗剂或化合物还可进一步降低生物机体对医疗器械进入生物机体的反应。此外，这些治疗药物、制剂和/或化合物还可用于促进愈合，包括预防血栓形成。这些药物、制剂和/或化合物还可用于治疗特定疾病，包括易损斑块和 2 型糖尿病患者的动脉粥样硬化。治疗剂也可输送到疾病部位的区域。在区域给药中，液体制剂可能是提高特定药物疗效和可给药性的理想选择。此外，还可对装置进行改良，以促进内皮化。可利用各种材料和涂层方法将药剂或化合物保持在医疗器械上，直至输送和定位。此外，还可对用于递送植入式医疗器械的装置进行改良，以降低在递送过程中损坏植入式医疗器械的可能性。此外，还可利用各种聚合物组合来控制治疗药物、药剂和/或化合物从植入式医疗器械中的洗脱率。
• Extraction of solvents from drug containing polymer reservoirs
  申请人：Cordis Corporation

  公开号：EP2123312A2

  公开（公告）日：2009-11-25

  A process for reducing solvent contents in drug-containing polymeric compositions, contained in reservoirs in a medical device, involves first reducing the solvent content by one or more conventional drying methods to a range from about 0.5 weight percent to about 10 weight percent of the total weight of the polymeric composition. Subsequently, the drug-containing polymeric compositions are further treated by a low temperature drying method for further reduction of the solvent content.

  一种用于降低医疗设备储液器中含药聚合物组合物中溶剂含量的工艺，包括首先通过一种或多种常规干燥方法将溶剂含量降至聚合物组合物总重量的约 0.5% 至约 10% 的范围内。随后，用低温干燥法进一步处理含药聚合物组合物，以进一步降低溶剂含量。