tert-butyl (2S,3R)-2-((R)-7-((2S,3S)-1-(tert-butoxycarbonyl)-2-((R)-1-oxohept-6-en-2-yl)piperidin-3-yl)-1-oxoheptan-2-yl)-3-vinylpiperidine-1-carboxylate | 1255151-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl (2S,3R)-2-((R)-7-((2S,3S)-1-(tert-butoxycarbonyl)-2-((R)-1-oxohept-6-en-2-yl)piperidin-3-yl)-1-oxoheptan-2-yl)-3-vinylpiperidine-1-carboxylate
• CAS: 1255151-05-3
• 化学式: C₃₆H₆₀N₂O₆
• 分子量: 616.882
• InChiKey: CKUJNQRFLCLPET-JNRWAQIZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.14
• 重原子数：
  44.0
• 可旋转键数：
  15.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  93.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (2S,3R)-2-((R)-7-((2S,3S)-1-(tert-butoxycarbonyl)-2-((R)-1-oxohept-6-en-2-yl)piperidin-3-yl)-1-oxoheptan-2-yl)-3-vinylpiperidine-1-carboxylate 、 异丙烯基溴化镁 在 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl (2S,3S)-3-[(6R)-6-[(2S,3R)-3-ethenyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-2-yl]-7-hydroxy-8-methylnon-8-enyl]-2-[(4R)-3-hydroxy-2-methylnona-1,8-dien-4-yl]piperidine-1-carboxylate
  参考文献：
  名称：

  Enantioselective Total Synthesis of (−)- and (+)-Petrosin

  摘要：

  The enantioselective total synthesis of (-)- and (+)-petrosin is described. The union of two key segments was executed by Suzuki Miyaura coupling. The quinolizidine rings were stereoselectively constructed via a diastereoselective Mannich reaction and an aza-Michael reaction. The 16-membered ring was constructed by ring-closing metathesis with the second-generation Grubbs catalyst.

  DOI：

  10.1021/ol1022257
• 作为产物：
  描述：

  在 三氧化硫吡啶 、 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 生成 tert-butyl (2S,3R)-2-((R)-7-((2S,3S)-1-(tert-butoxycarbonyl)-2-((R)-1-oxohept-6-en-2-yl)piperidin-3-yl)-1-oxoheptan-2-yl)-3-vinylpiperidine-1-carboxylate
  参考文献：
  名称：

  Enantioselective Total Synthesis of (−)- and (+)-Petrosin

  摘要：

  The enantioselective total synthesis of (-)- and (+)-petrosin is described. The union of two key segments was executed by Suzuki Miyaura coupling. The quinolizidine rings were stereoselectively constructed via a diastereoselective Mannich reaction and an aza-Michael reaction. The 16-membered ring was constructed by ring-closing metathesis with the second-generation Grubbs catalyst.

  DOI：

  10.1021/ol1022257