N-(1-ethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl) methacrylamide | 1268277-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-(1-ethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl) methacrylamide
• 英文别名: N-(1-ethyl-2-pyridin-4-ylbenzimidazol-5-yl)-2-methylprop-2-enamide
• CAS: 1268277-06-0
• 化学式: C₁₈H₁₈N₄O
• 分子量: 306.367
• InChiKey: QWVKDOHSTQIUFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N1-乙基-4-硝基苯-1,2-二胺 在 palladium 10% on activated carbon 、 一水合肼 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 N-(1-ethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl) methacrylamide
  参考文献：
  名称：

  A ratiometric hydrophilic fluorescent copolymer sensor based on benzimidazole chromophore for microbioreactors

  摘要：

  The ratiometric approach is robust and insensitive to factors such as source intensity, photobleaching, or orientation of the patch. A novel ratiometric hydrophilic copolymer of N-(1-ethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl)methacrylamide and 2-hydroxyethyl methacrylate (P(BIPy-HEMA)) containing pyridyl substituted benzimidazole moiety as pH sensor has been developed. Its fluorescence in aqueous system showed two obvious isosbestic points due to two-stepwise protonation. According to the linear curves of I-462/I-423 and I-536/I-462 to pH, such ratiometric pH values could be read directly without external calibration. Considering the hydrophilicity, stability and repeatability in aqueous environment, the fluorescent film with ratiometric characteristic over acidic pH range of 1.7-4.5 makes it high promising for online monitor in microbioreactors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2010.03.016

文献信息

• A ratiometric hydrophilic fluorescent copolymer sensor based on benzimidazole chromophore for microbioreactors
  作者：Liangjun Shen、Ping Zhao、Weihong Zhu

  DOI：10.1016/j.dyepig.2010.03.016

  日期：2011.6

  The ratiometric approach is robust and insensitive to factors such as source intensity, photobleaching, or orientation of the patch. A novel ratiometric hydrophilic copolymer of N-(1-ethyl-2-(pyridin-4-yl)-1H-benzo[d]imidazol-5-yl)methacrylamide and 2-hydroxyethyl methacrylate (P(BIPy-HEMA)) containing pyridyl substituted benzimidazole moiety as pH sensor has been developed. Its fluorescence in aqueous system showed two obvious isosbestic points due to two-stepwise protonation. According to the linear curves of I-462/I-423 and I-536/I-462 to pH, such ratiometric pH values could be read directly without external calibration. Considering the hydrophilicity, stability and repeatability in aqueous environment, the fluorescent film with ratiometric characteristic over acidic pH range of 1.7-4.5 makes it high promising for online monitor in microbioreactors. (C) 2010 Elsevier Ltd. All rights reserved.