5-methylpyrazin-2-yl-methylphosphonic acid diethyl ester | 918550-34-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 5-methylpyrazin-2-yl-methylphosphonic acid diethyl ester
• 英文别名: Diethyl P-[(5-methyl-2-pyrazinyl)methyl]phosphonate；2-(diethoxyphosphorylmethyl)-5-methylpyrazine
• CAS: 918550-34-2
• 化学式: C₁₀H₁₇N₂O₃P
• 分子量: 244.23
• InChiKey: LKGNXYAGOOMMHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-methylpyrazin-2-yl-methylphosphonic acid diethyl ester 、 3,5-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-(methoxymethoxy)benzaldehyde 在 potassium tert-butylate 、 甲醇 、 三氟乙酸 作用下， 以 四氢呋喃 为溶剂， 生成 2,6-bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-[(E)-2-(5-methylpyrazin-2-yl)ethenyl]phenol
  参考文献：
  名称：

  A selective fluorescent sensor for Pb(II) in water

  摘要：

  A new fluorescent sensor (1) containing bis(2-pyridylmethyl)amine group as a binding moiety for Pb2+ was developed. Compound I shows selective response to Pb2+ over other metal ions in pH 7.0 HEPES buffer solution. The fluorescence intensity enhancement was ascribed to the complex formation between Pb2+ and 1 which blocked the photo-induced electron transfer process. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.10.060
• 作为产物：
  描述：

  2,5-二甲基吡嗪 、 亚磷酸三乙酯 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 生成 5-methylpyrazin-2-yl-methylphosphonic acid diethyl ester
  参考文献：
  名称：

  A selective fluorescent sensor for Pb(II) in water

  摘要：

  A new fluorescent sensor (1) containing bis(2-pyridylmethyl)amine group as a binding moiety for Pb2+ was developed. Compound I shows selective response to Pb2+ over other metal ions in pH 7.0 HEPES buffer solution. The fluorescence intensity enhancement was ascribed to the complex formation between Pb2+ and 1 which blocked the photo-induced electron transfer process. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.10.060

文献信息

• CYCLOPENTYLACRYLAMIDE DERIVATIVE
  申请人：Fukuda Yasumichi

  公开号：US20110160211A1

  公开（公告）日：2011-06-30

  A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): (wherein R 1 and R 2 are each independently a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a hydroxyamino group, a nitro group, a cyano group, a sulfamoyl group, a C 1 to C 6 alkyl group, a C 1 to C 6 alkoxy group, a C 1 to C 6 alkylsulfanyl group, a C 1 to C 6 alkylsulfinyl group, a C 1 to C 6 alkylsulfonyl group, or a C 1 to C 6 alkoxy-C 1 to C 6 alkylsulfonyl group, and A is a substituted or unsubstituted heteroaryl group).

  提供了一种具有降血糖作用的化合物。该化合物及其药学上可接受的盐可用于治疗或预防糖尿病、肥胖症等疾病。该化合物由一般式（1）表示：（其中R1和R2分别独立地为氢原子、卤素原子、氨基、羟基、羟基氨基、硝基、氰基、磺酰基、C1到C6烷基、C1到C6烷氧基、C1到C6烷基硫基、C1到C6烷基亚砜基、C1到C6烷基磺酰基或C1到C6烷氧基-C1到C6烷基磺酰基；A为取代或未取代的杂环芳基）。
• Fluorinated Heteroaryls
  申请人：Benbow John W.

  公开号：US20110130365A1

  公开（公告）日：2011-06-02

  The present invention provides Formula (1A) XN O R 3 HN R 5 O R 4 R 2 R 1 (1A) 5 compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the glucokinase enzyme, where X, R 1, R 2, R 3, R 4, and R 5 are as described herein.

  本发明提供了公式（1A）XN O R3 HN R5 O R4 R2 R1（1A）的5种化合物，这些化合物作为葡萄糖激酶激活剂；其制药组合物；以及治疗通过葡萄糖激酶酶介导的疾病、紊乱或情况的方法，其中X，R1，R2，R3，R4和R5如本文所述。
• NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME
  申请人：Ryono Denis E.

  公开号：US20110118211A1

  公开（公告）日：2011-05-19

  Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R 4 is —(CH 2 ) n —Z—(CH 2 ) m PO(OR 7 )(OR 8 ), —(CH 2 ) n Z—(CH 2 ) m —PO(OR 7 )R 9 , —(CH 2 ) n —Z—(CH 2 ) m —OPO(OR 7 )R 9 , —(CH 2 ) n Z—(CH 2 ) m —OPO(R 9 )(R 10 ), or —(CH 2 ) n Z—(CH 2 ) m —PO(R 9 )(R 10 ); R 5 and R 6 are independently selected from H, alkyl and halogen; Y is R 7 (CH 2 ) s or is absent; and X, n, Z, m, R 4 , R 5 , R 6 , R 7 , and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
• US8153677B2
  申请人：——

  公开号：US8153677B2

  公开（公告）日：2012-04-10
• US8946440B2
  申请人：——

  公开号：US8946440B2

  公开（公告）日：2015-02-03