N,N'-p-xylylenebisacetamide | 3154-96-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-p-xylylenebisacetamide
• 英文别名: N-[[4-(acetamidomethyl)phenyl]methyl]acetamide
• CAS: 3154-96-9
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: HUCYCLRRROVLPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-p-xylylenebisacetamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以61%的产率得到N,N'-diethyl-p-xylylenediamine
  参考文献：
  名称：

  Synthesis of Water-soluble Diaza-1,2,5-thiadiazolocyclophanes

  摘要：

  DOI：

  10.3987/com-97-s71
• 作为产物：
  描述：

  1,4-苯二甲胺 、 乙酰氯 在 sodium hydroxide 作用下， 反应 3.0h， 以54%的产率得到N,N'-p-xylylenebisacetamide
  参考文献：
  名称：

  Synthesis of Water-soluble Diaza-1,2,5-thiadiazolocyclophanes

  摘要：

  DOI：

  10.3987/com-97-s71

文献信息

• Organic Compounds
  申请人：Collingwood Stephen Paul

  公开号：US20080312217A1

  公开（公告）日：2008-12-18

  A Compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M 1 , M 1 , L 1 , L 2 , W 1 , W 2 , X 1 , X 2 , Y 1 , Y 2 , A, R 5 , and R 5a are as defined herein for the treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition.

  化合物式（I）或其互变异构体、立体异构体、溶剂化物或药学上可接受的盐，其中M1、M1、L1、L2、W1、W2、X1、X2、Y1、Y2、A、R5和R5a的定义如本文所述，用于治疗由于阻断上皮钠通道介导的情况，特别是炎症或过敏症。
• Epithelial sodium channel (ENaC) inhibitors
  申请人：Novartis AG

  公开号：EP2332933A1

  公开（公告）日：2011-06-15

  A compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.

  式 (I) 的化合物 或其同分异构体、立体异构体、或其溶解物、或其药学上可接受的盐、 其中 M1、M2、L1、L2、W1、W2、X1、X2、Y1、Y2、A、R5 和 R5a 如本文所定义，用于治疗可通过阻断上皮钠通道治疗的疾病，特别是受益于粘膜水合作用的疾病。
• Polymeric lanthanide complexes with extended reach bisamide ligands
  作者：David M.L Goodgame、David A Grachvogel、Izhar Hussain、David J Williams

  DOI：10.1016/s0020-1693(99)00568-x

  日期：2000.4

  It is shown by X-ray structural studies that the bisamide ligands N,N'-p-xylylenebisacetamide (PXBA, I), N,N'-trans-1,4-cyclohexylaminebisacetamide (1,CCHBA, II) and N,N'-trans-1,4-cyclohexylaminebis-n-butyramide (1,4-CHBB, III) form polymeric network structures with lanthanide(III) nitrates. In the compound Er-2(PXBA)(3)(NO3)(6) (1) the erbium atoms are nine-coordinate and are linked by PXBA bridges to form sheets of contiguous 78-membered metallacyclic rings. In Ce(1,4-CHBA)(2)(NO3)(3) (2) the cerium atoms are ten-coordinate and the 1,4-CHBA ligands bridge adjacent cerium centres to form sheets of contiguous 44-membered rings with (4,4) topology and with a very compact stacking of the adjacent sheets. In Nd(1,4-CHBB)(2)(NO3)(3) (3) the neodymium atoms are eight-coordinate with the 1,4-CHBB ligands also bridging adjacent neodymium centres to form sheets of contiguous 44-membered rings with (4,4) topology, but with a pronounced 'square-wave' corrugation and crest-in-trough sheet stacking. (C) 2000 Elsevier Science S.A. All rights reserved.
• ORGANIC COMPOUNDS
  申请人：Novartis AG

  公开号：EP2155721B1

  公开（公告）日：2011-02-23
• STRICTLY SEGMENTED THERMOPLASTIC ELASTOMERS AS BIODEGRADABLE BIOMATERIALS
  申请人：Symo-chem B.V.

  公开号：EP3157978B1

  公开（公告）日：2021-08-11