N-[6-(6-purinylamino)caproyloxy]succinimide | 331473-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N-[6-(6-purinylamino)caproyloxy]succinimide
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 6-(7H-purin-6-ylamino)hexanoate
• CAS: 331473-83-7
• 化学式: C₁₅H₁₈N₆O₄
• 分子量: 346.346
• InChiKey: FZKCLXUMTHXDES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-[6-(6-purinylamino)caproyloxy]succinimide 、 在 dipotassium hydrogenphosphate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以60%的产率得到
  参考文献：
  名称：

  Multifunctional dinucleotide analogs for the generation of complex RNA conjugates

  摘要：

  Oligonucleotide conjugates are needed for in vitro selection schemes aiming at reactions between small, organic reactants. A general strategy is provided for the generation of the required RNA reactant conjugates based on multifunctional dinucleotide analogs. These modified dinucleotides allow for enzymatic ligation to native or enzymatically transcribed RNAs. They further contain a flexible polyethylene glycol spacer for correct spatial positioning and a photolabile cleavage site for selective release. The dinucleotides can be derivatized with the desired organic compounds by activated ester chemistry as was demonstrated by coupling to several nucleobases and nucleotides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01114-5
• 作为产物：
  描述：

  6-氯嘌呤 在 盐酸 、 sodium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 六甲基磷酰三胺 、 水 为溶剂， 反应 3.0h， 生成 N-[6-(6-purinylamino)caproyloxy]succinimide
  参考文献：
  名称：

  Multifunctional dinucleotide analogs for the generation of complex RNA conjugates

  摘要：

  Oligonucleotide conjugates are needed for in vitro selection schemes aiming at reactions between small, organic reactants. A general strategy is provided for the generation of the required RNA reactant conjugates based on multifunctional dinucleotide analogs. These modified dinucleotides allow for enzymatic ligation to native or enzymatically transcribed RNAs. They further contain a flexible polyethylene glycol spacer for correct spatial positioning and a photolabile cleavage site for selective release. The dinucleotides can be derivatized with the desired organic compounds by activated ester chemistry as was demonstrated by coupling to several nucleobases and nucleotides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01114-5