2,6-Dimethyl-4-propoxyanilin | 53984-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,6-Dimethyl-4-propoxyanilin
• 英文别名: 4-Propoxy-2.6-xylidin；2,6-dimethyl-4-propoxyaniline
• CAS: 53984-32-0
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: ZVBAPPZCAFKUKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-Dimethyl-4-propoxyanilin 生成 2-Bromo-N-(2,6-dimethyl-4-propoxy-phenyl)-propionamide
  参考文献：
  名称：

  BYRNES E. W.; MCMASTER P. D.; SMITH E. R.; BLAIR M. R.; BOYES R. N.; DUCE+, J. MED. CHEM., 1979, 22, NO 10, 1171-1176

  摘要：

  DOI：
• 作为产物：
  描述：

  生成 2,6-Dimethyl-4-propoxyanilin
  参考文献：
  名称：

  Local anesthetic compounds and uses

  摘要：

  本发明揭示了用于产生长时期局部麻醉的新化合物、药物组合物和方法。本发明的化合物是多结合化合物，包括从2到10个配体共价连接到一个或多个连接物的结构，每个配体能够结合到电压门控Na+通道中的一个配体结合位点，以调节其生物过程/功能。

  公开号：

  US06337423B1

文献信息

• Primary aminoacylanilides, methods of making the same and use as
  申请人：Astra Pharmaceutical Products, Inc.

  公开号：US04218477A1

  公开（公告）日：1980-08-19

  Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R.sub.8 can also be methyl; (b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl; (c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only; (d) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 are hydrogen, and n is 0, then R.sub.6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route.

  主要氨基酰基苯胺的结构式为##STR1##其中R.sub.1从氢、甲基、乙基和丙基中选择，R.sub.2从甲基、乙基、氯、甲氧基和乙氧基中选择，R.sub.3从氢和甲基中选择，R.sub.4从氢、甲基和C.sub.1 -C.sub.4烷氧基中选择，R.sub.6从甲基、乙基、氯、甲氧基和乙氧基中选择，R.sub.7为氢、甲基或乙基，R.sub.8为氢，R.sub.9为氢、甲基或乙基，R.sub.10为氢，n为0或1，具体规定如下：(a)当n为0时，R.sub.8也可以是甲基；(b)当n为1且R.sub.7为氢，R.sub.9为氢或甲基时，R.sub.10也可以是甲基；(c)当R.sub.1为氢，R.sub.2为甲基，R.sub.3为氢，R.sub.6为甲基，R.sub.7为氢，R.sub.8为氢，n为0时，R.sub.4只能是乙氧基或丙氧基；(d)当R.sub.1为氢，R.sub.2为甲基，R.sub.3、R.sub.4、R.sub.7和R.sub.8为氢，n为0时，R.sub.6只能是甲氧基、乙氧基或乙基；以及其治疗上可接受的盐。已发现这类化合物在口服给药时，特别是作为长效心脏抗心律失常药物，具有良好的疗效。
• Primary aminoacylanilides
  申请人：Astra Pharmaceutical Products, Inc.

  公开号：US04237068A1

  公开（公告）日：1980-12-02

  Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R.sub.8 can also be methyl; (b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl; (c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only; (d) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 are hydrogen, and n is 0, then R.sub.6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route.

  式子为##STR1##的一级氨基苯甲酰胺，其中R.sub.1选自氢、甲基、乙基和丙基组成的群体，R.sub.2选自甲基、乙基、氯、甲氧基和乙氧基组成的群体，R.sub.3选自氢和甲基组成的群体，R.sub.4选自氢、甲基和C.sub.1-C.sub.4烷氧基组成的群体，R.sub.6选自甲基、乙基、氯、甲氧基和乙氧基组成的群体，R.sub.7为氢、甲基或乙基，R.sub.8为氢，R.sub.9为氢、甲基或乙基，R.sub.10为氢，n为0或1，条件是（a）当n为0时，R.sub.8也可以是甲基；（b）当n为1，且R.sub.7为氢，R.sub.9为氢或甲基时，R.sub.10也可以是甲基；（c）当R.sub.1为氢，R.sub.2为甲基，R.sub.3为氢，R.sub.6为甲基，R.sub.7为氢，R.sub.8为氢，n为0时，R.sub.4只能是乙氧基或丙氧基；（d）当R.sub.1为氢，R.sub.2为甲基，R.sub.3、R.sub.4、R.sub.7和R.sub.8为氢，n为0时，R.sub.6只能是甲氧基、乙氧基或乙基；以及其治疗上可接受的盐。已发现此类化合物在口服时可以成为有效的长效心脏抗心律失常药物。
• Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof
  申请人：Evans Karen

  公开号：US20070249670A1

  公开（公告）日：2007-10-25

  The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

  本发明涉及糖原磷酸化酶抑制剂化合物、这些化合物的药物组合物、使用这些药物组合物治疗糖尿病、与糖尿病相关的疾病和/或组织缺血，包括心肌缺血的方法，以及制备这些化合物的过程。
• ORGANIC ELECTROLUMINESCENT ELEMENT, NOVEL COMPOUND, LIGHTING DEVICE AND DISPLAY DEVICE
  申请人：Konica Minolta Holdings, Inc.

  公开号：EP2453496A1

  公开（公告）日：2012-05-16

  Provided are an organic electroluminescent element having high luminous efficiency, low driving voltage, and long life; novel compound; lighting device; and display device.

  本文提供了一种具有高发光效率、低驱动电压和长寿命的有机电致发光元件、新型化合物、照明设备和显示设备。
• ORGANIC ELECTROLUMINESCENT ELEMENT, AND ILLUMINATION DEVICE AND DISPLAY DEVICE EACH COMPRISING THE ELEMENT
  申请人：Konica Minolta Holdings, Inc.

  公开号：EP3046156A1

  公开（公告）日：2016-07-20

  Disclosed is an organic electroluminescent element which has high luminous efficiency, a low driving voltage, excellent heat resistance, excellent raw stock storability and a long service life.

  本发明公开了一种有机电致发光元件，它具有高发光效率、低驱动电压、优异的耐热性、出色的原材料储存性和较长的使用寿命。