1,6-dioxa-cyclotetradecane-2,5-dione | 141850-47-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: 1,6-dioxa-cyclotetradecane-2,5-dione
• 英文别名: 1,6-Dioxa-cyclotetradecan-2,5-dion；Octamethylene succinate；1,6-dioxacyclotetradecane-2,5-dione
• CAS: 141850-47-7
• 化学式: C₁₂H₂₀O₄
• 分子量: 228.288
• InChiKey: AGGIPDJGPHEIKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Succinic acid mono-(8-iodo-octyl) ester 在 silver tetrafluoroborate 、 caesium carbonate 作用下， 以 丙酮 为溶剂， 反应 84.0h， 生成 1,6-dioxa-cyclotetradecane-2,5-dione
  参考文献：
  名称：

  Synthesis of macrocyclic dilactones by cyclization of sulfonium salts

  摘要：

  An efficient method for the formation of macrocyclic dilactones via cyclization of (omega-carboxyalkyl)diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described. These sulfonium salts 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11- to 16-membered dilactones 4 in good yields. The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11-membered dilactonic pyrrolizidine alkaloid, 13,13-dimethyl-1,2-didehydrocrotalanine 23.

  DOI：

  10.1021/jo00040a013

文献信息

• Cosmetic and dermatological preparations comprising an isoflavone content and the use of isoflavones for producing cosmetic and dermatological preparations for reducing the sebum content of the skin
  申请人：——

  公开号：US20040170655A1

  公开（公告）日：2004-09-02

  Use of isoflavones for producing preparations for reducing sebum production and/or for establishing a normal sebum homeostasis, as well as for the prophylaxis and treatment of greasy hair and dandruff.

  异黄酮用于生产减少皮脂分泌和/或建立正常皮脂平衡的制剂，以及预防和治疗油腻发质和头皮屑。
• Cosmetic and dermatological preparations comprising a content of a hop extract or hop-malt extract and the utilization of a hop extract or hop-malt extract for producing cosmetic and dermatological preparations for reducing the sebum contents of the skin
  申请人：——

  公开号：US20040141938A1

  公开（公告）日：2004-07-22

  Use of a hop extract or a hop-malt extract for producing preparations for reducing sebum production and/or for establishing a normal sebum homeostasis, as well as for the prophylaxis and treatment of acne, blemished skin, greasy hair and dandruff.

  酒花提取物或酒花麦芽提取物用于生产减少皮脂分泌和/或建立正常皮脂平衡的制剂，以及用于预防和治疗痤疮、瑕疵皮肤、油腻头发和头皮屑。
• Meta and Para Rings¹
  作者：E. W. Spanagel、Wallace H. Carothers

  DOI：10.1021/ja01308a047

  日期：1935.5
• [EN] COMPOUNDS FOR QUENCHING REACTIVE METAL CATALYTIC SPECIES REMAINED IN POLYESTER POLYOL RESINS, QUENCHING PROCESS AND ITS APPLICATION IN POLYURETHANE PRODUCTION THEREIN<br/>[FR] COMPOSÉS POUR LA DÉSACTIVATION D'ESPÈCES CATALYTIQUES MÉTALLIQUES RÉSIDUELLES DANS DES RÉSINES À BASE DE POLYOL DE POLYESTER, PROCÉDÉ DE DÉSACTIVATION ET SON APPLICATION DANS LA PRODUCTION DE POLYURÉTHANNE
  申请人：BAYER MATERIALSCIENCE AG

  公开号：WO2011018161A1

  公开（公告）日：2011-02-17

  A method to produce polyester polyol resin with quenched or deactivated residual catalytic metal ion species therein is disclosed. Feature organic compounds of macrocyclic ethers, alkyl and/or aryl substituted phoshine, alkyl and/or aryl substituted phosphine oxides, alkyl and/or aryl substituted phosphine sulfides, alkyl and/or aryl substituted quaternary ammonium halide salts are used as effective deactivation compounds to quench the unfavorable activities of residual metal ion species originated from the metal Lewis acid catalyst(s) during a continuous two-step process of polyester polyol production. Two deactivation processes denoted as the pre-deactivation process and the post-deactivation process are also disclosed. The polyester polyol resin product of present invention may be used as active-hydrogen atoms containing raw material for successive production of diverse two-component based polyurethane with decreased -OH/-NCO adduction rates, better color appearances and improved product qualities.
• Synthesis of macrocyclic dilactones by cyclization of sulfonium salts
  作者：Takako Nakamura、Haruo Matsuyama、Nobumasa Kamigata、Masahiko Iyoda

  DOI：10.1021/jo00040a013

  日期：1992.7

  An efficient method for the formation of macrocyclic dilactones via cyclization of (omega-carboxyalkyl)diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described. These sulfonium salts 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11- to 16-membered dilactones 4 in good yields. The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11-membered dilactonic pyrrolizidine alkaloid, 13,13-dimethyl-1,2-didehydrocrotalanine 23.