1-(2-Aminoethyl)-3-(2,6-dibromphenyl)-thioharnstoff | 75257-54-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Aminoethyl)-3-(2,6-dibromphenyl)-thioharnstoff
• 英文别名: 1-(2-aminoethyl)-3-(2,6-dibromophenyl)-thiourea；1-(2-Aminoethyl)-3-(2,6-dibromophenyl)thiourea
• CAS: 75257-54-4
• 化学式: C₉H₁₁Br₂N₃S
• 分子量: 353.08
• InChiKey: WXEUOYNJQUDBSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-dibromophenylthiourea 以 四氢呋喃 、 氯苯 为溶剂， 反应 20.0h， 生成 1-(2-Aminoethyl)-3-(2,6-dibromphenyl)-thioharnstoff
  参考文献：
  名称：

  Antihypertensive (2-aminoethyl)thiourea derivatives. 1

  摘要：

  Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.

  DOI：

  10.1021/jm00186a019

文献信息

• Thiourea derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04066695A1

  公开（公告）日：1978-01-03

  Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.

  具有抗高血压活性的噻脲衍生物的化学式如下：##STR1## 其中R、R.sub.1、R.sub.2、R.sub.3和X如下所述，以及使用化合物的方法的化学式如下：##STR2## 其中R.sub.1'、R.sub.2'、R.sub.3和X如前所述，或者化合物II的化学式作为抗高血压药剂。
• Method of treating depression with thiourea derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04169154A1

  公开（公告）日：1979-09-25

  A method of utilizing thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as agents in the treatment of depression, is described.

  本发明涉及一种利用以下式子中的硫脲衍生物作为抗抑郁药物的方法：##STR1## 其中R，R.sub.1，R.sub.2，R.sub.3和X的定义如下。
• Method of reducing blood pressure with thiourea derivatives and
  申请人：Hoffmann-La Roche Inc.

  公开号：US04150138A1

  公开（公告）日：1979-04-17

  Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.

  本文描述了公式 ##STR1## 中的R、R.sub.1、R.sub.2、R.sub.3和X的定义，以及公式 ##STR2## 中的R.sub.1'、R.sub.2'、R.sub.3和X的定义，这些化合物是抗高血压活性的硫脲衍生物。同时，本文还描述了使用公式II的化合物或公式II本身作为抗高血压剂的方法。
• Thiourea derivatives for treating hypertension
  申请人：Hoffmann-La Roche Inc.

  公开号：US04096276A1

  公开（公告）日：1978-06-20

  Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, As well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, Or a compound of formula II as an anti-hypertensive agent, is described.

  本文描述了公式##STR1##中R、R.sub.1、R.sub.2、R.sub.3和X的定义，以及具有降压活性的硫脲衍生物。同时，还描述了使用公式##STR2##中R.sub.1'、R.sub.2'、R.sub.3和X的定义，或公式II的化合物作为抗高血压药物的方法。
• 1-(2-Aminoethyl)-3-(2,6-dihalophenyl)guanidines
  申请人：Hoffmann-La Roche Inc.

  公开号：US04113776A1

  公开（公告）日：1978-09-12

  Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.

  本发明涉及公式为##STR1##的硫脲衍生物，其中R、R.sub.1、R.sub.2、R.sub.3和X如下所述，以及使用公式为##STR2##的化合物的方法，其中R.sub.1'、R.sub.2'、R.sub.3和X如上所述，或者使用公式II的化合物作为抗高血压药物。