(S)-α-Chlor-n-capronsaeure | 32653-33-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-α-Chlor-n-capronsaeure
• 英文别名: L-2-chloro-hexanoic acid ;levorotatory form；L-2-Chlor-hexansaeure;linksdrehende Form；(2S)-2-Chlorohexanoic acid
• CAS: 32653-33-1
• 化学式: C₆H₁₁ClO₂
• 分子量: 150.605
• InChiKey: OMPRMWFZHLNRQJ-YFKPBYRVSA-N

物化性质

• 沸点：
  236.1±13.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-α-Chlor-n-capronsaeure 生成 (S)-3-Chloro-2-methyl-heptan-2-ol
  参考文献：
  名称：

  发酵面包酵母不对称还原Z-3-氯-3-烯键-2-酮

  摘要：

  使用发酵的面包酵母，首先在>; 98％ee中将Z = RCH = CClCOCH 3（R = C 2 H 5，nC 5 H 11，nC 8 H 17）还原为（S）-RCH 2 HOHCH 3。 syn（2S，3S）/ anti（2S，3R）比率为2.6〜18.3。

  DOI：

  10.1016/s0040-4039(00)85052-2
• 作为产物：
  描述：

  3-氯-1-庚烯 在 氯仿 作用下， 生成 (S)-α-Chlor-n-capronsaeure
  参考文献：
  名称：

  Levene; Haller, Journal of Biological Chemistry, 1929, vol. 83, p. 597

  摘要：

  DOI：

文献信息

• Asymmetric Synthesis of 2-chloro- and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals
  作者：P Angibaud、J.L Chaumette、J.R Desmurs、L Duhamel、G Plé、J.Y Valnot、P Duhamel

  DOI：10.1016/0957-4166(95)00251-j

  日期：1995.8

  2-chloro-alkanoic acids 6 and 7 have been obtained the diastereoselective halogenation of chiral silyl ketene acetals 3a-f, and subsequent saponification of the resulting crude esters. Examples characterized by e.e. values up to 95% are reported. The diastereoface selectivity is independent of the silyl ketene acetal configuration.

  光学活性的（S）-2-溴-和2-氯-链烷酸6和7已经获得了手性甲硅烷基烯酮缩醛3a-f的非对映选择性卤化，随后将所得的粗酯皂化。报告了以ee值高达95％为特征的示例。非对映体的选择性与甲硅烷基烯酮缩醛构型无关。
• Asymmetric Transformation of 2-Phenyl- and 2-Chloroalkanoic Acids<i>via</i>Chiral Oxazolines
  作者：Saizo Shibata、Hajime Matsushita、Hajime Kaneko、Masao Noguchi、Masahiko Saburi、Sadao Yoshikawa

  DOI：10.1246/bcsj.55.3546

  日期：1982.11

  Asymmetric transformation of racemic 2-phenyl- and 2-chloroalkanoic acids via oxazolines into the corresponding optically active acids was investigated using (S)-phenylalaninol as a chiral auxiliary. The asymmetric transformation was performed by metalation of the oxazolines with butyllithium followed by protonation of the resulting lithiooxazolines. 2-Phenyl- and 2-chloroalkanoic acids were obtained in the optical yields of 29–53% and 45–73%, respectively, by the acidic hydrolysis of the chiral oxazolines thus formed. The mechanism of the asymmetric transformation was discussed.

  以（S）-苯丙氨醇为手性助剂，研究了外消旋2-苯基-和2-氯烷酸通过恶唑啉转化为相应光学活性酸的不对称转化。通过用丁基锂对恶唑啉进行金属化，然后对生成的锂氧唑啉进行质子化，实现了不对称转化。通过手性恶唑啉的酸性水解，分别获得了光学收率29-53%和45-73%的2-苯基-和2-氯烷酸。讨论了不对称转化的机理。
• Heppke, G.; Loetzsch, D.; Sharma, N. K., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 241, p. 275 - 288
  作者：Heppke, G.、Loetzsch, D.、Sharma, N. K.、Demus, D.、Diele, S.、et al.

  DOI：——

  日期：——
• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.