2-(dimethylamino)ethyl N-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)carbamate | 1149624-58-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(dimethylamino)ethyl N-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)carbamate
• CAS: 1149624-58-7
• 化学式: C₁₃H₁₅F₁₃N₂O₂
• 分子量: 478.254
• InChiKey: YIJGWAPLZNBZLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  1,4-二溴丁烷 、 2-(dimethylamino)ethyl N-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)carbamate 以 氯仿 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

  摘要：

  A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against R aeruginosa. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.07.032
• 作为产物：
  描述：

  N,N-二甲基乙醇胺 、 2-perfluorohexyl ethyl isocyanate 以 乙醚 为溶剂， 以80%的产率得到2-(dimethylamino)ethyl N-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)carbamate
  参考文献：
  名称：

  Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

  摘要：

  A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against R aeruginosa. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.07.032

文献信息

• Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa
  作者：Lionel Massi、Frederic Guittard、Richard Levy、S. Géribaldi

  DOI：10.1016/j.ejmech.2008.07.032

  日期：2009.4

  A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against R aeruginosa. (c) 2008 Elsevier Masson SAS. All rights reserved.