(2S,3S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-5-methyl-8-triethylsilanyl-oct-7-ynal | 381214-08-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-5-methyl-8-triethylsilanyl-oct-7-ynal
• 英文别名: (2S,3S,5S)-2-[tert-butyl(dimethyl)silyl]oxy-3-[(4-methoxyphenyl)methoxy]-5-methyl-8-triethylsilyloct-7-ynal
• CAS: 381214-08-0
• 化学式: C₂₉H₅₀O₄Si₂
• 分子量: 518.885
• InChiKey: XRYOUHDKXYAACP-SAAIGDAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.64
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,3S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-5-methyl-8-triethylsilanyl-oct-7-ynal 在 四丁基氟化铵 、 4-甲基苯磺酸吡啶 、 溶剂黄146 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (2R,3R)-5-[(2R,4S)-5-azido-4-methylpentan-2-yl]-5-methoxy-2-[(1S,3S)-1-[(4-methoxyphenyl)methoxy]-3-methylhex-5-ynyl]oxolan-3-ol
  参考文献：
  名称：

  Synthesis of the (+)-C26–C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero-Michael Addition Strategy This work was supported by the United States National Institute of Environmental Health Sciences (NIEHS; grant number ES10615), NIH, and by Bristol-Myers Squibb (CJF). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH, or BMS. We thank Dr. A. B. Dounay and Dr. G. Florence for critical reading of the manuscript.

  摘要：

  DOI：

  10.1002/1521-3773(20011001)40:19<3663::aid-anie3663>3.0.co;2-u
• 作为产物：
  描述：

  (4R,2''RS)-4-methyl-6-(2-tetrahydropyranyloxy)1-hexyne 在 sodium tetrahydroborate 、 正丁基锂 、 N-甲基吲哚酮 、 四丙基高钌酸铵 、 4 Angstroem MS 、 三氟化硼乙醚 、 氯代二环己基硼烷 、 4-甲基苯磺酸吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 生成 (2S,3S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-5-methyl-8-triethylsilanyl-oct-7-ynal
  参考文献：
  名称：

  Synthesis of the (+)-C26–C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero-Michael Addition Strategy This work was supported by the United States National Institute of Environmental Health Sciences (NIEHS; grant number ES10615), NIH, and by Bristol-Myers Squibb (CJF). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH, or BMS. We thank Dr. A. B. Dounay and Dr. G. Florence for critical reading of the manuscript.

  摘要：

  DOI：

  10.1002/1521-3773(20011001)40:19<3663::aid-anie3663>3.0.co;2-u

文献信息

• Synthesis of the (+)-C26–C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero-Michael Addition Strategy This work was supported by the United States National Institute of Environmental Health Sciences (NIEHS; grant number ES10615), NIH, and by Bristol-Myers Squibb (CJF). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH, or BMS. We thank Dr. A. B. Dounay and Dr. G. Florence for critical reading of the manuscript.
  作者：Craig J. Forsyth、Junliang Hao、Josep Aiguade

  DOI：10.1002/1521-3773(20011001)40:19<3663::aid-anie3663>3.0.co;2-u

  日期：2001.10.1