2-fluoro-4-chloro-5-(3-methylcyclopentyl)oxyaniline | 141772-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-fluoro-4-chloro-5-(3-methylcyclopentyl)oxyaniline
• 英文别名: 4-chloro-2-fluoro-5-(3-methylcyclopentyl)oxyaniline
• CAS: 141772-44-3
• 化学式: C₁₂H₁₅ClFNO
• 分子量: 243.709
• InChiKey: PISRCJVQWYIXHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cyclopentylmethyl 4-methylbenzenesulfonate 、 5-氨基-2-氯-4-氟苯酚 在 sodium hydroxide 、 potassium iodide 、 四丁基溴化铵 作用下， 以 水 、 甲苯 为溶剂， 生成 2-fluoro-4-chloro-5-(3-methylcyclopentyl)oxyaniline
  参考文献：
  名称：

  Process for the production of aniline derivatives

  摘要：

  高效生产苯胺衍生物的工业过程，这些衍生物是制造噁唑烷二酮衍生物和四氢邻苯二甲酰亚胺衍生物的重要中间体，后者作为除草剂的活性成分。该过程从2,4-二卤-5-氨基酚或双(2,4-二卤-5-氨基苯基)碳酸酯开始，并在不保护氨基的情况下选择性地使羟基发生环烷基化或炔基化反应，从而可以高产率地生产具有环烷氧基或炔氧基的苯胺衍生物。

  公开号：

  US05639915A1

文献信息

• Tetrahydrophthalamide derivative, intermediate for producing the same,
  申请人：Sagami Chemical Research Center

  公开号：US05506190A1

  公开（公告）日：1996-04-09

  The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the compounds having a more efficient herbicidal activity, and efficient and industrial processes for the preparation thereof. More specifically, the tetrahydrophthalimide derivative obtained by reacting a halogen-substituted 5-cycloalkyloxyaniline derivative with a 3,4,5,6-tetrahydrophthalic anhydride, or the tetrahydroisophthalimide derivative of the present invention is reacted with various types of amines to prepare a tetrahydrophthalamide derivative represented by the general formula (I): ##STR1## These tetrahydrophthalamide derivatives and the tetrahydroisophthalimide derivatives exhibit excellent herbicidal activities in the soil treatment in the paddy field and field and the stem-foliar treatment. The tetrahydroisophthalimide derivatives are also useful as intermediates for the preparation of the tetrahydrophthalamide derivatives, etc.

  本发明涉及具有卓越除草剂有效活性成分的3,4,5,6-四氢邻苯二酰胺衍生物和3,4,5,6-四氢异苯二酰胺衍生物，以及其制备方法，并提供具有更高效的除草活性的化合物，以及其高效和工业化的制备方法。更具体地，通过将卤素取代的5-环烷氧基苯胺衍生物与3,4,5,6-四氢邻苯二酐反应获得的四氢邻苯二酰胺衍生物，或者将本发明的四氢异苯二酰胺衍生物与各种类型的胺反应以制备由通式（I）表示的四氢邻苯二酰胺衍生物：这些四氢邻苯二酰胺衍生物和四氢异苯二酰胺衍生物在稻田和田间土壤处理以及茎叶处理中表现出卓越的除草活性。四氢异苯二酰胺衍生物还可用作制备四氢邻苯二酰胺衍生物等的中间体。
• Benzene derivatives substituted with heterocyclic ring, and herbicides
  申请人：Sagami Chemical Research Center

  公开号：US05424277A1

  公开（公告）日：1995-06-13

  A benzene derivative substituted with a heterocyclic ring represented by the general formula: ##STR1## wherein R represents a cycloalkyl group having 3 to 8 carbon atoms, X represents a halogen atom, and Z represents ##STR2## in which said cycloalkyl group may be substituted with an alkyl group having 1 to 6 carbon atoms, a process for preparing the same, and a herbicidal agent comprising the above compound as an active ingredient are disclosed. The compound has an excellent effect in that the compound exhibits a markedly high herbicidal effect on weeds in the field and the paddy field at a low dose and yet exhibits markedly low noxious effects on main crops.

  本发明涉及一种苯环衍生物，其被杂环环代替，通式如下：##STR1## 其中，R代表3至8个碳原子的环烷基团，X代表卤素原子，Z代表##STR2## 在该环烷基团可以被1至6个碳原子的烷基团取代的情况下，揭示了制备该化合物的过程以及以该化合物为活性成分的除草剂。该化合物具有显著的优点，即在低剂量下，该化合物对田间和稻田中的杂草表现出显著的高除草效果，同时对主要作物表现出显著的低有害作用。
• HETEROCYCLE-SUBSTITUTED BENZENE DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0493606A1

  公开（公告）日：1992-07-08

  A heterocycle-substituted benzene derivative represented by general formula (I) wherein R represents C₃ to C₈ cycloalkyl, X represents halogen, and Z represents (Ia) or (Ib) provided that the cycloalkyl may be substituted with C₁ to C₆ alkyl. This compound is excellent in that it has a remarkably high herbicidal effect against weeds growing in both upland and lowland fields in a low dose, while it has a remarkably low phytotoxicity against main crops.

  一种杂环取代的苯衍生物，由通式(I)表示，其中 R 代表 C₃ 至 C₈ 环烷基，X 代表卤素，Z 代表(Ia)或(Ib)，但环烷基可被 C₁ 至 C₆ 烷基取代。这种化合物的优异之处在于，它对生长在高地和低地的杂草都有显著的高剂量除草效果，而对主要作物的植物毒性却很低。
• TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0635485A1

  公开（公告）日：1995-01-25

  A 3,4,5,6-tetrahydrophthalamide derivative and a 3,4,5,6-tetrahydroisophthalimide derivative, both having an excellent efficay as the active ingredient of a herbicide, and an industrial process for efficiently producing these higher-performance, herbicidally active compounds. A tetrahydrophthalamide derivative represented by general formula (I) is produced by the reaction of a tetrahydrophthalimide derivative, prepared by the reaction of a halogenated 5-cycloalkyloxyaniline derivative with 3,4,5,6-tetrahydrophthalic anhydride, or of the tetrahydroisophthalimide derivative of the invention with various amines. These tetrahydrophthalamide and tetrahydroisophthalimide derivatives have an excellent herbicidal effect in the treatment of lowland and upland soils and foliage treatment. The tetrahydroisophthalimide derivative is useful also as an intermediate for producing the tetrahydrophthalamide derivative and the like.

  一种3,4,5,6-四氢邻苯二甲酰胺衍生物和一种3,4,5,6-四氢异邻苯二甲酰亚胺衍生物，这两种衍生物作为除草剂的活性成分具有极佳的功效，以及一种高效生产这些性能更佳、除草活性更强的化合物的工业工艺。通过卤化 5-环烷氧基苯胺衍生物与 3,4,5,6-四氢邻苯二甲酸酐反应制备的四氢邻苯二甲酰亚胺衍生物，或本发明的四氢异邻苯二甲酰亚胺衍生物与各种胺反应制备通式 (I) 所代表的四氢邻苯二甲酰亚胺衍生物。这些四氢邻苯二甲酰胺和四氢异邻苯二甲酰亚胺衍生物在处理低地和高地土壤和叶片方面具有极佳的除草效果。四氢异邻苯二甲酰亚胺衍生物还可用作生产四氢邻苯二甲酰胺衍生物等的中间体。
• PROCESS FOR PRODUCING ANILINE DERIVATIVE
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0659735A1

  公开（公告）日：1995-06-28

  A process for producing an aniline derivative represented by general formula (3) by reacting a halogenated aminophenol derivative represented by general formula (1) or a carbonate derivative thereof with an alkylating agent of the formula (R-Y) in the presence of a phase-transfer catalyst in a bilayered system composed of an aqueous solution of an alkali metal hydroxide and an organic solvent, wherein R represents (substituted) C₃-C₁₂ cycloalkyl or C₃-C₆ alkynyl; or a process for producing an aniline derivative represented by general formula (3) by reacting an aminophenol derivative represented by general formula (1) with an alkylating agent in the presence of an alkali metal carbonate in an organic solvent. The process enables an intermediate for producing an oxazolidinedione derivative useful as the active ingredient of a herbicide to be efficiently produced without the necessity for protecting the amino group.

  一种生产通式(3)代表的苯胺衍生物的工艺，其方法是在碱金属氢氧化物水溶液和有机溶剂组成的双层体系中，在相转移催化剂存在下，使通式(1)代表的卤代氨基苯酚衍生物或其碳酸盐衍生物与式(R-Y)的烷化剂反应、其中 R 代表（取代的）C₃-C₁₂ 环烷基或 C₃-C₆ 烷基；或通式(3)代表的苯胺衍生物的生产工艺，其方法是在有机溶剂中，在碱金属碳酸盐存在下，使通式(1)代表的氨基苯酚衍生物与烷化剂反应。该工艺可以有效地生产出一种用于生产可用作除草剂活性成分的噁唑烷二酮衍生物的中间体，而无需保护氨基。