4-chloro-3-(hydroxymethyl)benzoic acid | 1187238-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-3-(hydroxymethyl)benzoic acid
• CAS: 1187238-15-8
• 化学式: C₈H₇ClO₃
• 分子量: 186.595
• InChiKey: GMSTVHUHUQMNTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloro-3-(hydroxymethyl)benzoic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 生成 4-Chloro-3-(chloromethyl)benzoic acid
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054
• 作为产物：
  描述：

  3-溴甲基-4-氯苯甲酸甲酯 在 水 作用下， 以 甲醇 为溶剂， 生成 3-(Bromomethyl)-4-chlorobenzoic acid 、 4-chloro-3-(hydroxymethyl)benzoic acid
  参考文献：
  名称：

  Design, synthesis and identification of novel colchicine-derived immunosuppressant

  摘要：

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.054

文献信息

• [EN] INHIBITOR COMPOUNDS<br/>[FR] COMPOSÉS À TITRE D'INHIBITEURS
  申请人：AZERIA THERAPEUTICS LTD

  公开号：WO2020212697A1

  公开（公告）日：2020-10-22

  The present invention relates to compounds of Formula (I) that function as inhibitors of serum and glucocorticoid regulated kinase (SGK) activity: Formula (I) wherein X1, X2, Y1, Y2, Y3, Y4, R2, R3, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which SGK activity is implicated.

  本发明涉及作为血清和糖皮质激素调节激酶（SGK）活性抑制剂的化合物的公式（I）：公式（I）其中X1、X2、Y1、Y2、Y3、Y4、R2、R3、Y和Z分别如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增殖性疾病（如癌症）以及其他涉及SGK活性的疾病或症状中的用途。
• Compositions and Methods For Repelling Blood-Sucking and Biting Insects, Ticks and Mites
  申请人：The United States of America, as represented by the Secretary of Agriculture

  公开号：US20160165886A1

  公开（公告）日：2016-06-16

  Chromene derivatives based on a chromene amide isolated from Amyris texana . Also disclosed are compositions containing chromene derivatives (synthetic or natural) based on a chromene amide isolated from Amyris texana . Also methods for repelling blood-sucking and biting insects, ticks and mites involving treating (or exposing) an object (e.g., mammals such as humans) or area (e.g., a surface such as human skin) with a blood-sucking and biting insects, ticks and mites repelling effective amount of at least one compound selected from chromene derivatives (synthetic or natural) based on a chromene amide isolated from Amyris texana.

  基于从德克萨斯州梅树（Amyris texana）中分离出的一种香豆素酰胺的香豆素衍生物。还公开了含有基于从Amyris texana中分离出的香豆素酰胺的香豆素衍生物（合成或天然）的组合物。还公开了用于驱避吸血和咬人的昆虫、蜱和螨虫的方法，涉及使用至少选自基于从Amyris texana中分离出的香豆素酰胺的香豆素衍生物（合成或天然）的至少一种化合物的吸血和咬人的昆虫、蜱和螨虫驱避有效量来处理（或暴露）物体（例如哺乳动物如人类）或区域（例如表面如人类皮肤）。
• [EN] COMPOSITIONS AND METHODS FOR REPELLING BLOOD-SUCKING AND BITING INSECTS, TICKS AND MITES<br/>[FR] COMPOSITIONS ET MÉTHODES PERMETTANT DE REPOUSSER LES INSECTES, LES TIQUES ET LES MITES PIQUANTS ET SUCEURS DE SANG
  申请人：US AGRICULTURE

  公开号：WO2014137811A1

  公开（公告）日：2014-09-12

  Chromene derivatives based on a chromene amide isolated from Amyris texana. Also disclosed are compositions containing chromene derivatives (synthetic or natural) based on a chromene amide isolated from Amyris texana. Also methods for repelling blood-sucking and biting insects, ticks and mites involving treating (or exposing) an object (e.g., mammals such as humans) or area (e.g., a surface such as human skin) with a blood-sucking and biting insects, ticks and mites repelling effective amount of at least one compound selected from chromene derivatives (synthetic or natural) based on a chromene amide isolated from Amyris texana.

  基于从Amyris texana中分离出的一种chromene酰胺衍生物的chromene衍生物。还公开了含有基于Amyris texana中分离出的chromene酰胺的chromene衍生物（合成或天然）的组合物。还公开了用于驱避吸血和咬人的昆虫、蜱和螨虫的方法，该方法涉及使用至少一种从Amyris texana中分离出的chromene酰胺衍生物为基础的chromene衍生物（合成或天然）的驱避有效量处理（或暴露）物体（例如哺乳动物，如人类）或区域（例如表面，如人类皮肤）。
• US9763444B2
  申请人：——

  公开号：US9763444B2

  公开（公告）日：2017-09-19
• Design, synthesis and identification of novel colchicine-derived immunosuppressant
  作者：Dong-Jo Chang、Eun-Young Yoon、Geon-Bong Lee、Soon-Ok Kim、Wan-Joo Kim、Young-Myeong Kim、Jong-Wha Jung、Hongchan An、Young-Ger Suh

  DOI：10.1016/j.bmcl.2009.05.054

  日期：2009.8

  Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A. (C) 2009 Elsevier Ltd. All rights reserved.