1-bromo-4-(((4-nitrobenzyl)oxy)methyl)benzene | 121392-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-bromo-4-(((4-nitrobenzyl)oxy)methyl)benzene
• 英文别名: 4-bromobenzyl 4-nitrobenzyl ether；1-[(4-bromophenyl)methoxymethyl]-4-nitrobenzene
• CAS: 121392-28-7
• 化学式: C₁₄H₁₂BrNO₃
• 分子量: 322.158
• InChiKey: VPDLFNPOJOPLJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苄醇 、 对硝基溴化苄 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 生成 1-bromo-4-(((4-nitrobenzyl)oxy)methyl)benzene
  参考文献：
  名称：

  (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION

  摘要：

  公开号：

  EP0328643B1

文献信息

• Cosolvent-Promoted O-Benzylation with Silver(I) Oxide: Synthesis of 1′-Benzylated Sucrose Derivatives, Mechanistic Studies, and Scope Investigation
  作者：Lei Wang、Yasuyuki Hashidoko、Makoto Hashimoto

  DOI：10.1021/acs.joc.6b00144

  日期：2016.6.3

  simple, mild, and highly effective, and numerous 1′-benzylated sucrose derivatives were prepared including a photoreactive (trifluoromethyl)phenyldiazirine-based sucrose. The mechanisms of benzylation with primary and secondary benzyl bromides were also elaborated. Furthermore, the application scope with alcohols, glucose, and ribose derivatives was investigated.

  开发了一种助溶剂与Ag 2 O促进的O-苄基化策略。由CH的共溶剂2氯2和Ñ己烷，不仅可以提高碳水化合物反应的溶解性，但也增加了苄基化效率。在开发的方法中大大抑制了副产物的形成。该方法简单，温和且高效，并且制备了包括基于光反应性（三氟甲基）苯基二叠氮基的蔗糖在内的多种1'-苄基蔗糖衍生物。还详细说明了伯和仲苄基溴的苄基化机理。此外，研究了醇，葡萄糖和核糖衍生物的应用范围。
• Alpha-hydroperoxyisopropylphenyl compounds and process for preparing the
  申请人：Terumo Kabushiki Kaisha

  公开号：US05043142A1

  公开（公告）日：1991-08-27

  .alpha.-Hydroperoxyisopropylphenyl compounds are useful as an organic hydroxyperoxide content in test compositions for the measurement of peroxide-active substances and are effectively utilized for detecting peroxide-active substances such as blood or hemoglobin (occult blood). Test devices for the detection of occult blood are constituted of a carrier in which organic hydroperoxide, coloration indicator, buffering agent, wetting agent, activating agent and stabilizer are impregnated. If hemoglobin is present in a specimen, the organic hydroperoxide is activated to produce nascent oxygen with which the indicator is oxidized and develops color. Although 2,5-dimethylhexane-2,5-dihydroperoxide and cumene hydroperoxide have been employed as the organic hydroperoxide, they are disadvantageous in remarkable reduction of the detective sensitivity due to lack of the stability with elapse of time, pseudonegative judgement when vitamin C is contained in urine specimen, reduction of capacity in the multi-item test pieces for the detection of urinary components caused by discoloration of the adjacent test pieces, low coloration sensitivity, etc. The compounds of the present invention are improved in the above-mentioned defects. As typical examples of the .alpha.-hydroperoxy-isopropylphenyl compounds according to the invention are mentioned 4-(2,4,7-trioxaoctyl) cumene hydroperoxide, 4-(.alpha.-operoxyisopropyl)benzyl benzyl ether, 4-octyl cumene -hydroperoxyisopropyl)benzyl benzyl ether, 4-octyl cumene hydroperoxide, bis[4-(.alpha.-hydroperoxyisopropyl)benzyl]ether, N,N-dimethyl-]4-(.alpha.-hydroperoxyisopropyl)benzene]-sulfoamide and the like.

  .alpha.-羟基过氧基异丙基苯基化合物在测量过氧化物活性物质的测试组成物中作为有机羟基过氧化物含量是有用的，并且有效地用于检测过氧化物活性物质，例如血液或血红蛋白（隐血）。用于检测隐血的测试设备由载体组成，其中浸渍了有机羟基过氧化物、着色指示剂、缓冲剂、润湿剂、活化剂和稳定剂。如果标本中存在血红蛋白，则有机羟基过氧化物被激活产生新生氧，指示剂被氧化并变色。虽然2,5-二甲基己烷-2,5-二过氧化物和叔丁基苯羟基过氧化物被用作有机羟基过氧化物，但它们由于随着时间的流逝而稳定性不足，尿标本中含有维生素C时会出现假阴性判断，相邻测试片变色导致多项测试片检测尿组分的能力降低，着色敏感度低等缺点而不利于检测灵敏度的显著降低。本发明的化合物改善了上述缺陷。根据本发明，典型的α-羟基过氧基异丙基苯基化合物包括4-(2,4,7-三氧杂辛基)叔丁基苯羟基过氧化物、4-(α-羟基过氧基异丙基)苯基苯基醚、4-辛基叔丁基苯羟基过氧基异丙基)苯基苯基醚、4-辛基叔丁基苯羟基过氧化物、双[4-(α-羟基过氧基异丙基)苯基]醚、N,N-二甲基-[4-(α-羟基过氧基异丙基)苯基]-磺酰胺等。
• US5043142A
  申请人：——

  公开号：US5043142A

  公开（公告）日：1991-08-27
• (alpha)-HYDROPEROXYISOPROPYLPHENYL COMPOUNDS AND PROCESS FOR THEIR PREPARATION
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0328643B1

  公开（公告）日：1994-07-06