2-(1,1-diphenyl-methyl)-acrylic acid | 415974-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1,1-diphenyl-methyl)-acrylic acid
• 英文别名: 2-(Diphenylmethyl)prop-2-enoic acid；2-benzhydrylprop-2-enoic acid
• CAS: 415974-07-1
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: HRFFAWNLRVQJRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1,1-diphenyl-methyl)-acrylic acid 在 sodium hydroxide 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 29.0h， 生成 (S)-3-(1H-Indol-3-yl)-2-(2-mercaptomethyl-3,3-diphenyl-propionylamino)-propionic acid
  参考文献：
  名称：

  Toward an Optimal Joint Recognition of the S₁‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)

  摘要：

  The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three metallopeptidases-neutral endopeptidase (NEP, neprilysin), angiotensin-converting enzyme (ACE), and endothelin-converting enzyme (ECE-1)-we studied the common structural specificity of the S-1' subsites of these peptidases. Various mercaptoacyl amino acids of the general formula HS-CH2-CH(R-1')CO-Trp-OH, possessing more or less constrained R-1' side chains, were designed. The mercapto-acyl synthons contain one or two asymmetrical centers. The K-i values of the separated stereoisomers of the most efficient inhibitors were used to determine the stereochemical preference of each enzyme. A guideline for the joint inhibition of the three peptidases was obtained with the (2R,3R) isomer of compound 13b. Its K-i values on NEP, ACE, and ECE were 0.7, 43, and 26 nM, respectively.

  DOI：

  10.1021/jm0005454
• 作为产物：
  描述：

  ethyl 2-(1,1-diphenylmethyl)-2-propenoate 在 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以3.2 g的产率得到2-(1,1-diphenyl-methyl)-acrylic acid
  参考文献：
  名称：

  Toward an Optimal Joint Recognition of the S₁‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)

  摘要：

  The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three metallopeptidases-neutral endopeptidase (NEP, neprilysin), angiotensin-converting enzyme (ACE), and endothelin-converting enzyme (ECE-1)-we studied the common structural specificity of the S-1' subsites of these peptidases. Various mercaptoacyl amino acids of the general formula HS-CH2-CH(R-1')CO-Trp-OH, possessing more or less constrained R-1' side chains, were designed. The mercapto-acyl synthons contain one or two asymmetrical centers. The K-i values of the separated stereoisomers of the most efficient inhibitors were used to determine the stereochemical preference of each enzyme. A guideline for the joint inhibition of the three peptidases was obtained with the (2R,3R) isomer of compound 13b. Its K-i values on NEP, ACE, and ECE were 0.7, 43, and 26 nM, respectively.

  DOI：

  10.1021/jm0005454

文献信息

• CALIXARENE COMPOUND, CURABLE COMPOSITION, AND CURED PRODUCT
  申请人：DIC Corporation

  公开号：US20210198178A1

  公开（公告）日：2021-07-01

  A calixarene compound represented by formula (1) below is provided. The calixarene compound contains, per molecule, at least one —CH 2 OH group or phenolic hydroxy group and at least one carbon-carbon unsaturated bond. R 1 's are a structural moiety (A), which has a —CH 2 OH group; a structural moiety (B), which has a carbon-carbon unsaturated bond; a structural moiety (C), which has a —CH 2 OH group and a carbon-carbon unsaturated bond; a monovalent organic group (D), which is different from (A), (B), and (C); or a hydrogen atom (E). R 2 's are (A), (B), (C), (D), or (E) provided that not all R 2 's are (E). R 3 's are one of a hydrogen atom, an aliphatic hydrocarbon group, and an aryl group. n is 2 to 10. * is a point of attachment to an aromatic ring. A curable composition including the calixarene compound is provided. A cured product of the curable composition is provided.

  提供下面公式（1）所代表的一个杯芳烃化合物。该杯芳烃化合物每个分子至少含有一个—CH2OH基团或酚羟基，以及至少一个碳-碳不饱和键。R1是一个结构基团（A），含有一个—CH2OH基团；一个结构基团（B），含有一个碳-碳不饱和键；一个结构基团（C），含有一个—CH2OH基团和一个碳-碳不饱和键；一个与（A）、（B）和（C）不同的一价有机基团（D）；或一个氢原子（E）。R2是（A）、（B）、（C）、（D）或（E），但不能全部为（E）。R3是氢原子、脂肪烃基团或芳基之一。n为2至10。*表示连接到芳香环的位置。提供包含该杯芳烃化合物的可固化组合物。提供可固化组合物的固化产物。
• CALIXARENE COMPOUND AND CURABLE COMPOSITION
  申请人：DIC Corporation

  公开号：US20190276421A1

  公开（公告）日：2019-09-12

  A compound useful as a release agent, and a release agent, a curable composition, and a nanoimprint lithography resin material each containing the compound are provided. More specifically, a calixarene compound with a molecular structure represented by the following structural formula (1) and a composition containing the calixarene compound are provided. wherein R 1 denotes a structural moiety with a perfluoroalkyl group, R 2 denotes a hydrogen atom, a polar group, a polymerizable group, or a structural moiety with a polar group or a polymerizable group, R 3 denotes a hydrogen atom, an aliphatic hydrocarbon group that may have a substituent, or an aryl group that may have a substituent, n denotes an integer in the range of 2 to 10, and * denotes a bonding point with an aromatic ring.

  提供一种作为脱模剂的化合物，以及包含该化合物的脱模剂、可固化组合物和纳米压印光刻树脂材料。更具体地，提供一种分子结构由以下结构式（1）表示的杯芳烃化合物和含有该杯芳烃化合物的组合物。其中R1表示具有全氟烷基的结构基团，R2表示氢原子、极性基团、可聚合基团或具有极性基团或可聚合基团的结构基团，R3表示氢原子、可能具有取代基的脂肪烃基团或可能具有取代基的芳基团，n表示在2到10范围内的整数，*表示与芳香环的结合点。
• NANOPARTICLE/DISPERSANT COMPLEX, NANOPARTICLE DISPERSION LIQUID, AND NANOPARTICLE/MATRIX-MATERIAL COMPLEX
  申请人：Kato Jun

  公开号：US20110144061A1

  公开（公告）日：2011-06-16

  Provided are a nanoparticle/dispersant complex having excellent dispersibility and long-term stability in a dispersion medium, a production method therefor, and a nanoparticle dispersion liquid and a nanoparticle/matrix-material complex which are colorless and transparent even at high concentrations. In the nanoparticle/dispersant complex, a nanoparticle is covered with a dispersant containing a heterocyclic cationic group and one of an oxo acid group containing a sulfur atom or a phosphorus atom and an anion moiety of the oxo acid group; in the nanoparticle dispersion liquid, the nanoparticle/dispersant complex is dispersed into a dispersion medium; in the nanoparticle/matrix-material complex, the nanoparticle/dispersant complex is dispersed into a matrix material; and the production method for a nanoparticle/dispersant complex comprises forming, under a presence of the dispersant, a nanoparticle covered with the dispersant from a nanoparticle precursor.

  提供了一种在分散介质中具有优异分散性和长期稳定性的纳米颗粒/分散剂复合物，以及其生产方法，以及即使在高浓度下也是无色透明的纳米颗粒分散液和纳米颗粒/基质材料复合物。在纳米颗粒/分散剂复合物中，纳米颗粒被含有杂环阳离子基团和含有硫原子或磷原子的氧酸基团之一以及氧酸基团的阴离子基团的分散剂覆盖；在纳米颗粒分散液中，纳米颗粒/分散剂复合物分散在分散介质中；在纳米颗粒/基质材料复合物中，纳米颗粒/分散剂复合物分散在基质材料中；纳米颗粒/分散剂复合物的生产方法包括在分散剂存在下，从纳米颗粒前体形成被分散剂覆盖的纳米颗粒。
• TRIPHENYL MONOMERS SUITABLE FOR MICROSTRUCTURED OPTICAL FILMS
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20150141692A1

  公开（公告）日：2015-05-21

  Optical films are described having a polymerized microstructured surface that comprises the reaction product of a polymerizable resin composition comprising at least one polymerizable ethylenically unsaturated triphenyl monomer. Also described are certain triphenyl (meth)acrylate monomers and polymerizable resin compositions.

  光学薄膜被描述为具有聚合微结构表面，其包括由至少含有一种聚合性乙烯不饱和三苯基单体的聚合性树脂组成的树脂组合物的反应产物。还描述了某些三苯基（甲基）丙烯酸酯单体和聚合性树脂组合物。
• [EN] OPTICAL FILMS COMPRISING FLUORENOL (METH)ACRYLATE MONOMER<br/>[FR] FILMS OPTIQUES À BASE DE MONOMÈRE DE (MÉTH)ACRYLATE DE FLUORÉNOL
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2009134594A1

  公开（公告）日：2009-11-05

  Microstructured optical films and polymerizable resin compositions comprising at one aromatic monomer or oligomer having at least two polymerizable (meth)acrylate groups and a fluorenol (meth)acrylate monomer.

  微结构光学薄膜和聚合物树脂组合物，包含至少一个含有至少两个可聚合（甲基）丙烯酸酯基团的芳香族单体或寡聚体和一种芴酚（甲基）丙烯酸酯单体。