4-Methyl-heptane-1,7-diamine | 54032-98-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-Methyl-heptane-1,7-diamine
• 英文别名: 4-Methylheptane-1,7-diamine
• CAS: 54032-98-3
• 化学式: C₈H₂₀N₂
• mdl: MFCD02093842
• 分子量: 144.26
• InChiKey: HPEGWEYHUFSYBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-甲基异硫脲硫酸盐 、 4-Methyl-heptane-1,7-diamine 以 水 为溶剂， 以44%的产率得到N-(7-Guanidino-4-methyl-heptyl)-guanidine; compound with sulfuric acid
  参考文献：
  名称：

  Branched-chain and unsaturated 1,7-Diaminoheptane derivatives as deoxyhypusine synthase inhibitors

  摘要：

  Deoxyhypusine synthase catalyzes the first step in the posttranslational biosynthesis of the unusual amino acid hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine] in eukaryotic translation initiation factor 5A (eIF-SA). eIF-SA and its single hypusine residue are essential for cell proliferation. Two series of 1,7-diaminoheptane derivatives were prepared and tested as inhibitors of human deoxyhypusine synthase. These include branched-chain saturated derivatives and both branched- and straight-chain unsaturated derivatives providing size and positional variation in branching and different torsional constraints. Of the branched-chain compounds, 7-amino-1-guanidinooctane (39) proved to be the most potent inhibitor in vitro (IC50, 34 nM), while 1,7-diamino-trans-hept-3-ene (20a) displayed the greatest inhibition (IC50, 0.7 mu M) among the unsaturated compounds. Compound 39 also provided effective inhibition of hypusine production in Chinese hamster ovary cells in culture. Considerations of the in vitro inhibition data reported here, along with earlier findings, allowed some speculation concerning the conformation of the substrate spermidine during its productive interaction at the active site of deoxyhypusine synthase. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)10030-x
• 作为产物：
  描述：

  1,5-二溴-3-甲基戊烷 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成 4-Methyl-heptane-1,7-diamine
  参考文献：
  名称：

  Branched-chain and unsaturated 1,7-Diaminoheptane derivatives as deoxyhypusine synthase inhibitors

  摘要：

  Deoxyhypusine synthase catalyzes the first step in the posttranslational biosynthesis of the unusual amino acid hypusine [N-epsilon-(4-amino-2-hydroxybutyl)lysine] in eukaryotic translation initiation factor 5A (eIF-SA). eIF-SA and its single hypusine residue are essential for cell proliferation. Two series of 1,7-diaminoheptane derivatives were prepared and tested as inhibitors of human deoxyhypusine synthase. These include branched-chain saturated derivatives and both branched- and straight-chain unsaturated derivatives providing size and positional variation in branching and different torsional constraints. Of the branched-chain compounds, 7-amino-1-guanidinooctane (39) proved to be the most potent inhibitor in vitro (IC50, 34 nM), while 1,7-diamino-trans-hept-3-ene (20a) displayed the greatest inhibition (IC50, 0.7 mu M) among the unsaturated compounds. Compound 39 also provided effective inhibition of hypusine production in Chinese hamster ovary cells in culture. Considerations of the in vitro inhibition data reported here, along with earlier findings, allowed some speculation concerning the conformation of the substrate spermidine during its productive interaction at the active site of deoxyhypusine synthase. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)10030-x

文献信息

• CARBON FIBER-REINFORCED THERMOPLASTIC RESIN COMPOSITION, AND PELLETS AND MOLDED ARTICLE THEREOF
  申请人：Toray Industries, Inc.

  公开号：EP2787045A1

  公开（公告）日：2014-10-08

  A carbon fiber-reinforced thermoplastic resin composition comprising a thermoplastic resin (A), a carbon fiber (B), and a carbon fiber (C), and a molded article produced by molding the carbon fiber-reinforced thermoplastic resin composition, the amount of the thermoplastic resin (A) being 10 to 65% by weight, the amount of the carbon fiber (B) being 35 to 90% by weight, based on 100% by weight of the total amount of the thermoplastic resin (A) and the carbon fiber (B), and the amount of the titanium compound (C) being 0.1 to 5 parts by weight, based on 100 parts by weight of the total amount of the thermoplastic resin (A) and the carbon fiber (B). Provided are a carbon fiber-reinforced thermoplastic resin composition having excellent mechanical properties, surface appearance, and the like, particularly, high flexural modulus, high strength, and excellent appearance/designability, and a molded article thereof.

  一种碳纤维增强热塑性树脂组合物，包括热塑性树脂（A）、碳纤维（B）和碳纤维（C），以及通过模塑该碳纤维增强热塑性树脂组合物生产的模塑制品，其中热塑性树脂（A）的用量为 10 至 65%（按重量计），碳纤维（B）的用量为 35 至 90%（按重量计），基于热塑性树脂（A）和碳纤维（B）总量的 100%（按重量计），以及钛化合物（C）的用量为 0.1 至 5 份（按重量计），基于热塑性树脂（A）和碳纤维（B）总量的 100 份（按重量计）。以热塑性树脂（A）和碳纤维（B）总量的 100 重量份计，钛化合物（C）的量为 0.1 至 5 重量份。 本发明提供了一种碳纤维增强热塑性树脂组合物，该组合物具有优异的机械性能、表面外观等，特别是具有高弯曲模量、高强度和优异的外观/可设计性，并提供了一种模塑制品。
• Polyamide resin pellet for a miniature part
  申请人：——

  公开号：US20020115818A1

  公开（公告）日：2002-08-22

  A polyamide resin pellet for a miniature part, comprising a polyamide resin (A) whose melting point as measured by DSC is in the range of 280 to below 330° C., which has an average volume of 0.001 to 21 mm 3 , the average volume determined by randomly sampling 50 pellets, measuring the weight and specific gravity of each of the pellets and dividing the weight by the specific gravity. The polyamide resin pellet exhibits low water absorption and is excellent in moldability, mechanical strength characteristics and heat resistance. Further, it has specified average volume, configuration, average diameter and average length, so that, in an injection molding, plasticization is smoothly effected to thereby enable obtaining a molded item or article which exhibits low dispersion of weight and strength and has excellent hue. The polyamide resin pellet is especially suitable for use in a molding material for forming miniature parts for motor vehicles and electrical or electronic equipments.

  一种用于微型部件的聚酰胺树脂颗粒，包括聚酰胺树脂 (A)，其 DSC 测量熔点范围为 280 至低于 330 摄氏度，平均体积为 0.001 至 21 毫米 3 平均体积是通过随机取样 50 个颗粒，测量每个颗粒的重量和比重并用重量除以比重来确定的。聚酰胺树脂颗粒的吸水性低，具有优异的成型性、机械强度特性和耐热性。此外，它还具有特定的平均体积、构型、平均直径和平均长度，因此在注塑成型时可顺利进行塑化，从而获得重量和强度分散性低且色调优异的成型物品或制品。这种聚酰胺树脂颗粒尤其适用于汽车和电气或电子设备微型零件的成型材料。
• Urethane prepolymer, process for producing the same and pressure-sensitive adhesive comprising the same
  申请人：Kyoeisha Chemical Co., Ltd.

  公开号：EP0882749B1

  公开（公告）日：2004-03-24
• SEALING MATERIAL, PROCESS FOR PRODUCTION OF THE MATERIAL, AND GASKET USING THE MATERIAL
  申请人：Hiraiwa Toshihiko

  公开号：US20100105797A1

  公开（公告）日：2010-04-29

  A sealing material which comprises (A) an unsaturated group-containing ester-type urethane oligomer which is an energy ray-curable liquid resin and (B) a compound having at least one carbodiimide group in the molecule in an amount of 0.01 to 10 parts by mass based on 100 parts by mass of the component (A) and which is excellent in moist heat durability, can retain low moisture permeability, is excellent in adhesion to a material to be jointed and can form a highly precise extrusion shape; a process for production of a scaling material excellent in long-term storage stability; a scaling material produced by the process; a gasket using a sealing material having the above-mentioned properties. A cured product of the sealing material has a reduced surface adhesion property, enables the easy removal of an HDD cover, and consequently is improved in durability against an external force produced at the time of reuse.
• MULTISTAGE GASKET
  申请人：Uranaka Masaki

  公开号：US20110038077A1

  公开（公告）日：2011-02-17

  A multi-stage gasket having a multi-stage structure constituted by multiple kinds of gasket materials and being used by holding between a cover plate and a base plate, the multi-stage gasket having contactness of a gasket as the lowermost layer to the cover plate or the base plate in contact with the gasket that is higher than contactness of a gasket as the uppermost layer to the cover plate or the base plate in contact with the gasket. A gasket can be provided that provides good reworkability of a cover plate and a base plate of a hard disk device, provides sufficient adhesiveness of the gasket to a cover plate and a base plate even when used in a high humidity and temperature environment, and is prevented from being toppled sideways or peeled off even when applied with a force in an oblique direction.