(E)-4-(4-bromobenzylidene)-2-phenyloxazol-5(4H)-one | 1200450-87-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-4-(4-bromobenzylidene)-2-phenyloxazol-5(4H)-one
• 英文别名: 4-(4-Bromo-benzylidene)-2-phenyl-4H-oxazol-5-one；(4E)-4-[(4-bromophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
• CAS: 1200450-87-8
• 化学式: C₁₆H₁₀BrNO₂
• 分子量: 328.165
• InChiKey: FKVLAHXEKNXHCF-GXDHUFHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-苯基-(4z)-(41-溴苯亚甲基)-5(4H)-口恶唑酮 以 乙腈 为溶剂， 以25%的产率得到(E)-4-(4-bromobenzylidene)-2-phenyloxazol-5(4H)-one
  参考文献：
  名称：

  Benzylidene-Oxazolones as Molecular Photoswitches

  摘要：

  The synthesis and photochemical study of a family of molecular switches inspired by the green fluorescent protein (UP) chromophore is presented. These compounds can be easily synthesized, and their photophysical properties may be tuned. Due to their efficient photoisomerization and high stability, these compounds can be switched on/off by using light and heat or light with different wavelengths.

  DOI：

  10.1021/ol301741g

文献信息

• Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis
  申请人：——

  公开号：US20040180943A1

  公开（公告）日：2004-09-16

  Disclosed are compounds of the Formula I 1 and their use in a method of inhibiting the aggregation of amyloid proteins and in a method of imaging amyloid deposits.

  揭示了Formula I1的化合物及其在抑制淀粉样蛋白聚集的方法和成像淀粉样沉积的方法中的应用。
• Benzylidene-Oxazolones as Molecular Photoswitches
  作者：Marina Blanco-Lomas、Pedro J. Campos、Diego Sampedro

  DOI：10.1021/ol301741g

  日期：2012.9.7

  The synthesis and photochemical study of a family of molecular switches inspired by the green fluorescent protein (UP) chromophore is presented. These compounds can be easily synthesized, and their photophysical properties may be tuned. Due to their efficient photoisomerization and high stability, these compounds can be switched on/off by using light and heat or light with different wavelengths.
• Benzylidene–oxazolones as photoswitches: photochemistry and theoretical calculations
  作者：Ignacio Funes-Ardoiz、Marina Blanco-Lomas、Pedro J. Campos、Diego Sampedro

  DOI：10.1016/j.tet.2013.09.009

  日期：2013.11

  The photophysics and photochemistry of a family of compounds proposed as efficient molecular photoswitches is presented. The effect of different light sources, substituents and solvents in the photostationary state has been explored. A detailed mechanistic description is also discussed. (C) 2013 Elsevier Ltd. All rights reserved.