(RS)-2-(carbobenzyloxy)amino-1-methoxy-5-phenyl-3-pentanone | 655242-13-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RS)-2-(carbobenzyloxy)amino-1-methoxy-5-phenyl-3-pentanone
• 英文别名: benzyl N-(1-methoxy-3-oxo-5-phenylpentan-2-yl)carbamate
• CAS: 655242-13-0
• 化学式: C₂₀H₂₃NO₄
• 分子量: 341.407
• InChiKey: ONVIHMIJWQAQMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.13
• 重原子数：
  25.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.63
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (RS)-2-(carbobenzyloxy)amino-1-methoxy-5-phenyl-3-pentanone 在 palladium on activated charcoal 盐酸 、 氢气 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 N-(1-Methoxymethyl-2-oxo-4-phenyl-butyl)-acetamide
  参考文献：
  名称：

  Functionalized amido ketones: new anticonvulsant agents

  摘要：

  We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00434-6
• 作为产物：
  描述：

  Phenethylmagnesium chloride 在 正丁基锂 、 silver(l) oxide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 114.5h， 生成 (RS)-2-(carbobenzyloxy)amino-1-methoxy-5-phenyl-3-pentanone
  参考文献：
  名称：

  Functionalized amido ketones: new anticonvulsant agents

  摘要：

  We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00434-6

文献信息

• Functionalized amido ketones: new anticonvulsant agents
  作者：C BEGUIN

  DOI：10.1016/s0968-0896(03)00434-6

  日期：2003.9

  We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity. (C) 2003 Elsevier Ltd. All rights reserved.