Methyl 3-p-anisoloxypropionate | 18333-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Methyl 3-p-anisoloxypropionate
• 英文别名: methyl 3-(p-methoxyphenoxy)propionate；3-(4-Methoxy-phenoxy)-propionsaeure-methylester；Methyl 3-(4-methoxyphenoxy)propanoate
• CAS: 18333-12-5
• 化学式: C₁₁H₁₄O₄
• mdl: MFCD10694158
• 分子量: 210.23
• InChiKey: AKBHVBLEQNXNQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 3-(4-甲氧基苯氧基)丙酸 在 硫酸 作用下， 100.0 ℃ 、689.49 kPa 条件下， 反应 0.08h， 生成 Methyl 3-p-anisoloxypropionate
  参考文献：
  名称：

  Microwave-Assisted Esterification of Diverse Carboxylic Acids and Chiral Amino Acids

  摘要：

  A facile and efficient synthetic method of esters from their corresponding carboxylic acids and amino acids is described. The esterification reaction of carboxylic acids and amino acids could be greatly accelerated under microwave irradiation because the reactions described in this article took place in only 5min with almost quantitative yields, and distinct acidity of catalytic acids was well tolerated. Unlike the racemation problem in microwave-assisted N-acylation reactions, the esters of chiral amino acids could be achieved with retention of configuration under this condition.

  DOI：

  10.1080/00397910802279845

文献信息

• Simultaneous Generation of Methyl Esters and CO in Lignin Transformation
  作者：Mingyang Liu、Buxing Han、Paul J. Dyson

  DOI：10.1002/anie.202209093

  日期：2022.10.4

  Complete utilization of lignin: the methoxy groups in lignin react with carboxylic acids to generate methyl carboxylates (applied to the synthesis of pharmaceuticals), and the remaining carbon atoms of lignin react with oxygen to form CO predominantly, which may be used directly in carbonylation reactions.

  木质素的完全利用：木质素中的甲氧基与羧酸反应生成羧酸甲酯（用于药物合成），木质素的剩余碳原子主要与氧反应生成CO，可直接用于羰基化反应。
• CCL5 inhibitors
  申请人：AFECTA PHARMACEUTICALS, INC.

  公开号：US10940132B2

  公开（公告）日：2021-03-09

  Compounds, pharmaceutically acceptable salts, esters, prodrugs, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of CCL5 on mammalian cells, as well as methods of treatment for diseases involving the increased biological activity of CCL5.

  所公开的化合物、药学上可接受的盐、酯、原药及其药物组合物有助于抑制 CCL5 在哺乳动物细胞上的生物活性，以及治疗涉及 CCL5 生物活性增加的疾病的方法。
• Hayashi, Masatoshi; Wada, Kojiro; Munakata, Katsura, Agricultural and Biological Chemistry, 1983, vol. 47, # 11, p. 2653 - 2656
  作者：Hayashi, Masatoshi、Wada, Kojiro、Munakata, Katsura

  DOI：——

  日期：——
• New Nematicidal Metabolites from a Fungus,<i>Irpex lacteus</i>
  作者：Masatoshi Hayashi、Kojiro Wada、Katsura Munakata

  DOI：10.1080/00021369.1981.10864743

  日期：1981.6
• JPS5772938A
  申请人：——

  公开号：JPS5772938A

  公开（公告）日：1982-05-07