(-)-(4S,5R)-methyl 2-oxo-4-phenyloxazolidine-5-carboxylate | 351526-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (-)-(4S,5R)-methyl 2-oxo-4-phenyloxazolidine-5-carboxylate
• 英文别名: 2-Oxo-4-phenyl-oxazolidine-5-carboxylic acid methyl ester；methyl (4S,5R)-2-oxo-4-phenyl-1,3-oxazolidine-5-carboxylate
• CAS: 351526-56-2
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.213
• InChiKey: OFJHCOWGFPMLTB-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (E)-isopropyl cinnamate 在 四氧化锇 、 lithium hydrochloride monohydrate 、 氢化奎宁(蒽醌-1,4-二基)二醚 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 4.34h， 生成 (-)-(4S,5R)-methyl 2-oxo-4-phenyloxazolidine-5-carboxylate
  参考文献：
  名称：

  Alkyl 4-Chlorobenzoyloxycarbamates as Highly Effective Nitrogen Source Reagents for the Base-Free, Intermolecular Aminohydroxylation Reaction

  摘要：

  Ethyl- (7), benzyl- (8), tert-butyl- (9), and fluorenylmethyl-4-chlorobenzoyloxycarbamates (10) have been prepared as storable and easy-to-prepare nitrogen sources for use in the intermolecular Sharpless aminohydroxylation reaction and its asymmetric variant. These reagents were found to be effective under base-free reaction conditions. The scope and limitations of these methods have been explored using a variety of alkenes, among which, trans-cinnamates, in particular, proved to be good substrates.

  DOI：

  10.1021/jo1018816

文献信息

• [EN] IMPROVED AMINOHYDROXYLATION OF ALKENES<br/>[FR] AMINOHYDROXYLATION AMÉLIORÉE D'ALCÈNES
  申请人：IND RES LTD

  公开号：WO2011159177A1

  公开（公告）日：2011-12-22

  The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

  该发明涉及一种使用N-氧羰酸酯试剂（例如N-酰氧羰酸酯、N-烷氧羰酸酯和N-芳基氧羰酸酯试剂）对烯烃进行氨羟基化的方法。该发明特别涉及一种可以在无需添加碱的情况下进行的分子间氨羟基化反应。该发明还涉及新颖的N-氧羰酸酯试剂，这些试剂是稳定的结晶材料。该发明的方法在合成具有邻位氨基醇基团的化合物方面非常有用，例如具有生物活性的化合物。
• AMINOHYDROXYLATION OF ALKENES
  申请人：Mee Simon Peter Harold

  公开号：US20130274479A1

  公开（公告）日：2013-10-17

  The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

  本发明涉及使用N-氧化氨基甲酸酯试剂（例如N-酰氧基氨基甲酸酯、N-烷氧羰氧甲酸酯和N-芳烃氧羰氧甲酸酯试剂）进行烯烃氨基羟化的方法。本发明特别涉及可以在无添加碱的情况下进行的分子间氨基羟化反应。本发明还涉及新颖的N-氧化氨基甲酸酯试剂，其为稳定的晶体材料。本发明的方法在合成具有邻位氨基醇基团的化合物（例如具有生物活性的化合物）方面非常有用。
• US8987504B2
  申请人：——

  公开号：US8987504B2

  公开（公告）日：2015-03-24
• Alkyl 4-Chlorobenzoyloxycarbamates as Highly Effective Nitrogen Source Reagents for the Base-Free, Intermolecular Aminohydroxylation Reaction
  作者：Lawrence Harris、Simon P. H. Mee、Richard H. Furneaux、Graeme J. Gainsford、Andreas Luxenburger

  DOI：10.1021/jo1018816

  日期：2011.1.21

  Ethyl- (7), benzyl- (8), tert-butyl- (9), and fluorenylmethyl-4-chlorobenzoyloxycarbamates (10) have been prepared as storable and easy-to-prepare nitrogen sources for use in the intermolecular Sharpless aminohydroxylation reaction and its asymmetric variant. These reagents were found to be effective under base-free reaction conditions. The scope and limitations of these methods have been explored using a variety of alkenes, among which, trans-cinnamates, in particular, proved to be good substrates.